Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney, and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways.

Background: Jianpi Gushen Huayu Decoction (JPGS) has been used to clinically treat diabetic nephropathy (DN) for many years. However, the protective mechanism of JPGS in treating DN remains unclear.

Aim: To evaluate the therapeutic effects and the possible mechanism of JPGS on DN.

An In Vitro Brain Tumour Model in Organotypic Slice Cultures Displaying Epileptiform Activity.

Brain tumours have significant impacts on patients' quality of life, and current treatments have limited effectiveness. To improve understanding of tumour development and explore new therapies, researchers rely on experimental models. However, reproducing tumour-associated epilepsy (TAE) in these models has been challenging.

Mechanical study of alisol B 23-acetate on methionine and choline deficient diet-induced nonalcoholic steatohepatitis based on untargeted metabolomics.

Alisol B 23-acetate (AB23A) has been demonstrated to have beneficial effects on nonalcoholic steatohepatitis (NASH). However, the mechanisms of AB23A on NASH remain unclear. This study aimed to investigate the mechanisms underlying the metabolic regulatory effects of AB23A on NASH.

Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism.

Diabetic nephropathy (DN) is a metabolic disease wherein chronic hyperglycemia triggers various renal cell dysfunctions, eventually leading to progressive kidney failure. Michx. is a traditional Chinese herbal medicine.

Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats.

Introduction: Yu-Ye Tang (YYT) is a classical formula widely used in treatment of type 2 diabetes mellitus (T2DM). However, the specific mechanism of YYT in treating T2DM is not clear.

Methods: The aim of this study was to investigate the therapeutic effect of YYT on T2DM by establishing a rat model of T2DM.

Regulating the work function of silver catalysts surface engineering for enhanced CO electroreduction.

The work function can serve as a characteristic quantity to evaluate the catalytic activity due to its relationship with the surface structure of a material. However, what factors determine the influence of the work function on the electrochemical performance are still unclear. Herein, we elucidate the effect of the work function of Ag on the electrochemical reduction of CO to CO by controlling the ratio of exposed crystalline planes.

A silver catalyst with a high-energy surface prepared by plasma spraying for the hydrogen evolution reaction.

A self-supported silver electrode was prepared by plasma spraying and used for catalysing the hydrogen evolution reaction. Thanks to the non-equilibrium synthetic conditions, the silver catalyst exposes high-energy (200) crystal planes, which enhance the adsorption of hydrogen and improve the intrinsic catalytic activity. As a result, the silver catalyst delivers an overpotential of 349 mV at 10 mA cm, which was much lower than those of Ag foil (742 mV) and commercial Ag powder (657 mV).

The catalytic oxidation performance of toluene over the Ce-Mn-O catalysts: Effect of synthetic routes.

Ce-Mn-O catalysts were synthesized by impregnation (CM-IM), co-precipitation (CM-CP), citrate sol-gel (CM-SG) and hydrothermal (CM-HT) methods. The synthesis methods exhibited a great impact on the physicochemical properties of catalysts, resulting in different catalytic activity. The catalytic oxidation activity of toluene followed the sequence: CM-HT (T: 234 °C; T: 246 °C) > CM-SG (T: 242 °C; T: 249 °C) > CM-CP (T: 243 °C; T: 259 °C) > CM-IM (T: 251 °C; T: 261 °C), which was consistent with the sequence of surface relative percentage of C, Ce, Mn, O and r values.