Age-period-cohort analysis and projection of cancer mortality in Hong Kong, 1998-2030.

Objectives: To explore the relationship between immigration groups and cancer mortality, this study aimed to explore age, period, birth cohort effects and effects across genders and immigration groups on mortality rates of lung, pancreatic, colon, liver, prostate and stomach cancers and their projections.

Design, Setting, And Participants: Death registry data in Hong Kong between 1998 and 2021, which were stratified by age, sex and immigration status. Immigration status was classified into three groups: locals born in Hong Kong, long-stay immigrants and short-stay immigrants.

Modelling COVID-19 outbreak on the Diamond Princess ship using the public surveillance data.

The novel coronavirus disease 2019 (COVID-19) outbreak on the Diamond Princess (DP) ship has caused over 634 cases as of February 20, 2020. We model the transmission process on DP ship as a stochastic branching process, and estimate the reproduction number at the innitial phase of 2.9 (95%CrI: 1.

Superspreading and heterogeneity in transmission of SARS, MERS, and COVID-19: A systematic review.

Background: Severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19) have caused substantial public health burdens and global health threats. Understanding the superspreading potentials of these viruses are important for characterizing transmission patterns and informing strategic decision-making in disease control. This systematic review aimed to summarize the existing evidence on superspreading features and to compare the heterogeneity in transmission within and among various epidemics of SARS, MERS and COVID-19.

Correction: Predicting Antituberculosis Drug-Induced Liver Injury Using an Interpretable Machine Learning Method: Model Development and Validation Study.

[This corrects the article DOI: 10.2196/29226.].

Predicting Antituberculosis Drug-Induced Liver Injury Using an Interpretable Machine Learning Method: Model Development and Validation Study.

Background: Tuberculosis (TB) is a pandemic, being one of the top 10 causes of death and the main cause of death from a single source of infection. Drug-induced liver injury (DILI) is the most common and serious side effect during the treatment of TB.

Objective: We aim to predict the status of liver injury in patients with TB at the clinical treatment stage.

The shortage of hospital beds for COVID-19 and non-COVID-19 patients during the lockdown of Wuhan, China.

Background: The 76-day lockdown of Wuhan city has successfully contained the first wave of the coronavirus disease 2019 (COVID-19) outbreak. However, to date few studies have evaluated the hospital bed shortage for COVID-19 during the lockdown and none for non-COVID-19 patients, although such data are important for better preparedness of the future outbreak.

Methods: We built a compartmental model to estimate the daily numbers of hospital bed shortage for patients with mild, severe and critical COVID-19, taking account of underreport and diagnosis delay.

Obesity and COVID-19 in Adult Patients With Diabetes.

Obesity has caused wide concerns due to its high prevalence in patients with severe coronavirus disease 2019 (COVID-19). Coexistence of diabetes and obesity could cause an even higher risk of severe outcomes due to immunity dysfunction. We conducted a retrospective study in 1,637 adult patients who were admitted into an acute hospital in Wuhan, China.

Low dispersion in the infectiousness of COVID-19 cases implies difficulty in control.

The individual infectiousness of coronavirus disease 2019 (COVID-19), quantified by the number of secondary cases of a typical index case, is conventionally modelled by a negative-binomial (NB) distribution. Based on patient data of 9120 confirmed cases in China, we calculated the variation of the individual infectiousness, i.e.

Four-tier response system and spatial propagation of COVID-19 in China by a network model.

In order to investigate the effectiveness of lockdown and social distancing restrictions, which have been widely carried out as policy choice to curb the ongoing COVID-19 pandemic around the world, we formulate and discuss a staged and weighted network system based on a classical SEAIR epidemiological model. Five stages have been taken into consideration according to four-tier response to Public Health Crisis, which comes from the National Contingency Plan in China. Staggered basic reproduction number has been derived and we evaluate the effectiveness of lockdown and social distancing policies under different scenarios among 19 cities/regions in mainland China.

Unexpected positive correlation between human development index and risk of infections and deaths of COVID-19 in Italy.

In this analysis, we observed that human development index (an integrated index of life expectation, education and living standard) correlates with infection rate (proportion of confirmed cases among the population) and the fatality rate of COVID-19 in Italy based on data as of May 15, 2020. Further analysis showed that HDI is negatively correlated with cigarette consumption, whereas it is positively correlated with chronic disease and average annual gross salary. These factors may partially explain why unexpected positive correlation is observed between human development index and risk of infections and deaths of COVID-19 in Italy.

Blood pressure control and adverse outcomes of COVID-19 infection in patients with concomitant hypertension in Wuhan, China.

Hypertension is a common comorbidity in hospitalized patients with COVID-19 infection. This study aimed to estimate the risks of adverse events associated with in-hospital blood pressure (BP) control and the effects of angiotensin II receptor blocker (ARB) prescription in COVID-19 patients with concomitant hypertension. In this retrospective cohort study, the anonymized medical records of COVID-19 patients were retrieved from an acute field hospital in Wuhan, China.

Quantifying the improvement in confirmation efficiency of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the early phase of the outbreak in Hong Kong in 2020.

Backgrounds: The emerging virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused a large outbreak of coronavirus disease, COVID-19, in Wuhan, China, since December 2019. COVID-19 soon spread to other regions of China and overseas. In Hong Kong, local mitigation measures were implemented since the first imported case was confirmed on January 23, 2020.

Preliminary estimates of the reproduction number of the coronavirus disease (COVID-19) outbreak in Republic of Korea and Italy by 5 March 2020.

The novel coronavirus disease 2019 (COVID-19) outbreak has caused 6088 cases and 41 deaths in Republic of Korea, and 3144 cases and 107 death in Italy by 5 March 2020, respectively. We modelled the transmission process in the Republic of Korea and Italy with a stochastic model, and estimated the basic reproduction number R as 2.6 (95% CI: 2.

The relative transmissibility of asymptomatic COVID-19 infections among close contacts.

Asymptomatic transmission of the coronavirus disease 2019 is an important topic. A recent study in China showed that transmissibility of the asymptomatic cases is comparable to that of symptomatic cases. Here, we discuss that the conclusion may depend on how we interpret the data.

Early estimation of the case fatality rate of COVID-19 in mainland China: a data-driven analysis.

Background: An ongoing outbreak of pneumonia caused by a novel coronavirus [severe acute respiratory syndrome coronavirus (SARS-CoV)-2], named COVID-19, hit a major city of China, Wuhan in December 2019 and subsequently spread to other provinces/regions of China and overseas. Several studies have been done to estimate the basic reproduction number in the early phase of this outbreak, yet there are no reliable estimates of case fatality rate (CFR) for COVID-19 to date.

Methods: In this study, we used a purely data-driven statistical method to estimate the CFR in the early phase of the COVID-19 outbreak.

Preliminary estimation of the novel coronavirus disease (COVID-19) cases in Iran: A modelling analysis based on overseas cases and air travel data.

As of March 1, 2020, Iran had reported 987 novel coronavirus disease (COVID-19) cases, including 54 associated deaths. At least six neighboring countries (Bahrain, Iraq, Kuwait, Oman, Afghanistan, and Pakistan) had reported imported COVID-19 cases from Iran. In this study, air travel data and the numbers of cases from Iran imported into other Middle Eastern countries were used to estimate the number of COVID-19 cases in Iran.