A new cationic palladium(II) dithiocarbamate exhibits anti-inflammatory, analgesic, and antipyretic activities through inhibition of inflammatory mediators in in vivo models.

Inflammation is being a protective mechanism of the body towards the injury. However, chronic and progressive inflammation may lead to some chronic diseases. Due to the serious unwanted effects associated with available drugs, new and safe anti-inflammatory agents are still required.

Surgical Interventions for Renal Cell Carcinoma with Thrombus Extending into the Inferior Vena Cava: A Multidisciplinary Approach.

: To assess surgical strategies and the impact of a multidisciplinary approach on patients undergoing inferior vena caval thrombectomy for renal cell carcinoma and to evaluate perioperative morbidity and mortality associated with these procedures. : A retrospective audit for all adults who underwent nephrectomy and inferior vena caval thrombectomy from January 2008 till November 2018 at a University hospital. Patients with incomplete records were excluded from the study.

Femoral Vein Transposition Arteriovenous Fistula is a Feasible Option in "Selected" Patients as Hemodialysis Access.

: Lower extremity hemodialysis access is offered to the patients who have severe central venous stenosis. Femoral vein transposition arteriovenous fistula (FV tAVF) is an alternative to lower leg arteriovenous prosthetic grafts. Its safety and patency is under observation.

Alleviation of cadmium accumulation in maize (Zea mays L.) by foliar spray of zinc oxide nanoparticles and biochar to contaminated soil.

Due to the increase in area of cadmium (Cd)-contaminated soils worldwide, effective measures are necessary to minimize the Cd accumulation in cereals including maize (Zea mays L.) plant. A study was therefore performed to explore the effectiveness of foliar spray of zinc oxide (ZnO) nanoparticle (NPs) alone (0, 50, 75, 100 mg/L) or combined with soil application of biochar (1.

Enhanced lipid and starch productivity of microalga ( sp. ) with nitrogen limitation following effective pretreatments for biofuel production.

The study was conducted to evaluate the conditions to enhance the accumulation of lipids and starch in sp. for the production of biofuel. The sp.

PVP intercalated metallic WSe as NIR photothermal agents for efficient tumor ablation.

Transition metal dichalogenides (TMDCs) with unique layered structures hold promising potential as transducers for photothermal therapy. However, the low photothermal conversion efficiency and poor stability in some cases limit their practical applications. Herein, we demonstrate the fabrication of ultrathin homogeneous hybridized TMDC nanosheets and their use for highly efficient photothermal tumor ablation.

Molecular Docking, Computational, and Antithrombotic Studies of Novel 1,3,4-Oxadiazole Derivatives.

A new series of 1,3,4-oxadiazoles derivatives was synthesized, characterized, and evaluated for their in vitro and in vivo anti-thrombotic activity. Compounds (⁻) exhibited significant clot lysis with respect to reference drug streptokinase (30,000 IU), and enhanced clotting time (CT) values (130⁻342 s) than heparin (110 s). High affinity towards 1NFY with greater docking score was observed for the compounds (, , , , and ) than the control ligand RPR200095.

Footwear Affects Biomechanical Work And Knee Adduction Moment During Stance Phase In Medial Knee Osteoarthritic Male Pakistani Adults.

Objective: The objective of this study was to explore the effects of commonly used footwear in urban Pakistan on knee adduction moment (KAM), knee adduction angular impulse (KAAI) and biomechanical work at lower limb joints (both individually and collectively).

Methodology: Cinematographic gait analysis of 20 medial knee osteoarthritis patients (Kellgren-Lawrence Grade I and II, age: 55.48 ± 5.

Magnetic Isotropy/Anisotropy in Layered Metal Phosphorous Trichalcogenide MPS₃ (M = Mn, Fe)Single Crystals.

Despite the fact that two-dimensional layered magnetic materials hold immense potential applications in the field of spintronic devices, tunable magnetism is still a challenge due to the lack of controllable synthesis. Herein, high-quality single crystals MPS₃ (M= Mn, Fe) of millimeter size were synthesized through the chemical vapor transport method. After systemic structural characterizations, magnetic properties were studied on the bulk MPS₃ layers through experiments, along with first principle theoretical calculations.

Zinc and iron oxide nanoparticles improved the plant growth and reduced the oxidative stress and cadmium concentration in wheat.

The effects of seed priming with zinc oxide (ZnO) and iron (Fe) nanoparticles (NPs) on the growth and cadmium (Cd) accumulation by wheat (Triticum aestivum) were investigated. Seeds of wheat were primed with different concentrations of either ZnO NPs (0, 25, 50, 75, and 100 mg L) or Fe NPs (0, 5, 10, 15, and 20 mg L) for 24 h by continuous aeration and then the seeds were sown in a soil which was contaminated with Cd due to long-term application of sewage water. Plants were grown till maturity under natural conditions with 60-70% moisture contents of total soil water holding capacity throughout the experiment.

Zinc oxide nanoparticles alter the wheat physiological response and reduce the cadmium uptake by plants.

An experiment was performed to explore the interactive impacts of zinc oxide nanoparticles (ZnO NPs) and cadmium (Cd) on growth, yield, antioxidant enzymes, Cd and zinc (Zn) concentrations in wheat (Triticum aestivum). The ZnO NPs were applied both in Cd-contaminated soil and foliar spray (in separate studies) on wheat at different intervals and plants were harvested after physiological maturity. Results depicted that ZnO NPs enhanced the growth, photosynthesis, and grain yield, whereas Cd and Zn concentrations decreased and increased respectively in wheat shoots, roots and grains.

Transcriptome profiling of anti-müllerian hormone treated preantral/small antral mouse ovary follicles.

The predisposition for the initiation of folliculogenesis in mammals including humans is programmed to start at fetal life and continues until reproductive capacity. The follicles grow from a pool of primordial follicles which retain the major functions in the entire reproductive life of a female. Anti-müllerian hormone (AMH), a glycoprotein belonging to the transforming growth factor-beta family, has an inhibitory effect on ovarian follicle development.

Multiday EMG-Based Classification of Hand Motions with Deep Learning Techniques.

Pattern recognition of electromyography (EMG) signals can potentially improve the performance of myoelectric control for upper limb prostheses with respect to current clinical approaches based on direct control. However, the choice of features for classification is challenging and impacts long-term performance. Here, we propose the use of EMG raw signals as direct inputs to deep networks with intrinsic feature extraction capabilities recorded over multiple days.

Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome.

The dynamic shape of the endoplasmic reticulum (ER) is a reflection of its wide variety of critical cell biological functions. Consequently, perturbation of ER-shaping proteins can cause a range of human phenotypes. Here, we describe three affected children (from two consanguineous families) who carry homozygous loss-of-function mutations in LNPK (previously known as KIAA1715); this gene encodes lunapark, which is proposed to serve as a curvature-stabilizing protein within tubular three-way junctions of the ER.

Microsatellite based Genetic Variation among the Buffalo Breed Populations in Pakistan.

Introduction: Eight microsatellite loci were used to define genetic diversity among five native water buffalo breeds in Pakistan.

Material And Methods: Blood samples (10 mL) from 25 buffaloes of each of the Nili, Ravi, Nili-Ravi, Kundhi, and Azi-Kheli breeds were collected aseptically from the jugular vein into 50 ml Falcon tubes containing 200 µl of 0.5 M EDTA.

Efficiency of various sewage sludges and their biochars in improving selected soil properties and growth of wheat (Triticum aestivum).

Due to increasing demand of P fertilizers and gradual decrease in P resources, recyclable P is the focus of researchers in recent years. Sewage sludge (SS) is a municipal waste that contains appreciable amounts of P and probably other nutrients. In present study, the effects of various SS and their biochars (450 °C for 2 h) were investigated on soil properties and P uptake in wheat (Triticum aestivum) with and without P fertilizer.

Silicon nutrition lowers cadmium content of wheat cultivars by regulating transpiration rate and activity of antioxidant enzymes.

Given that cadmium (Cd) uptake by plants is linked to transpiration rate and activity of antioxidant enzymes and further that silicon (Si) can regulate them, it was hypothesized that improved Si nutrition could reduce Cd concentration in plants. Thus, present study was carried out to elucidate the positive effect of Si nutrition on the growth, activities of antioxidant enzymes and tissue cadmium (Cd) concentration in Cd-tolerant (Iqbal-2000) and Cd-sensitive wheat (Triticum aestivum L.) cultivars.

Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis.

gene is a constituent of the serine/threonine protein kinase family and plays a crucial role in synthesis of milk fats and cholesterol by regulating activity of the sterol regulatory element binding protein (SREBP). is highly conserved in mammals and its expression levels during the lactation periods of cattle are markedly increased. is highly expressed in the intestine followed by mammary gland and it is also expressed in immune cells.

Photocatalytic Dehydrogenation of Formic Acid on CdS Nanorods through Ni and Co Redox Mediation under Mild Conditions.

Selective release of hydrogen from formic acid (FA) is deemed feasible to solve issues associated with the production and storage of hydrogen. Here, we present a new efficient photocatalytic system consisting of CdS nanorods (NRs), Ni, and Co to liberate hydrogen from FA. The optimized noble-metal-free catalytic system employs Ni/Co as a redox mediator to relay electrons and holes from CdS NRs to the Ni and Co, respectively, which also deters the oxidation of CdS NRs.

Effect of season and breed on physiological and blood parameters in buffaloes.

In this Research Communication we describe the effect of temperature and humidity index (THI) on various physiological traits, the plasma heat shock protein 70 (HSP70), heat shock protein 90 (HSP90) and cortisol levels and other blood parameters in crossbred buffalo (Nili-Ravi × Murrah) and Mediterranean buffalo to compare their tolerance to heat stress. As expected, crossbred buffalo had a significantly higher rectal temperature (RT), body surface temperature (BT), respiratory rate (RR), HSP70 and HSP90 levels in summer compared to spring and winter. RT and BT were also significantly higher in spring compared to winter.

Effect of foliar-applied iron complexed with lysine on growth and cadmium (Cd) uptake in rice under Cd stress.

Contamination of soils with cadmium (Cd) is a serious problem worldwide. Rice (Oryza sativa L.) is reported to accumulate relatively higher Cd contents in consumable parts and is considered a main source of Cd toxicity to humans from rice-derived products.

Cadmium phytoremediation potential of Brassica crop species: A review.

Cadmium (Cd) is a highly toxic metal released into the environment through anthropogenic activities. Phytoremediation is a green technology used for the stabilization or remediation of Cd-contaminated soils. Brassica crop species can produce high biomass under a range of climatic and growing conditions, allowing for considerable uptake and accumulation of Cd, depending on species.

Clinical Spectrum and Outcome of Cerebral Venous Sinus Thrombosis in Children.

Objective: To determine clinical spectrum, neuroimaging finding and outcome of cerebral venous sinus thrombosis (CVST) in children.

Study Design: Descriptive and cross-sectional study.

Place And Duration Of Study: Department of Paediatric Neurology, Children's Hospital and Institute of Child Health, Lahore, from 2015 to 2016.