Electrophoretic deposition of polyvinyl alcohol, C-H NRs along with moringa on an SS substrate for orthopedic implant applications.

Metals are commonly used in bone implants due to their durability and load-bearing capabilities, yet they often suffer from biofilm growth and corrosion. To overcome these challenges, implants with enhanced biocompatibility, bioactivity, and antimicrobial properties are preferred. Stainless steel (SS) implants are widely favored in orthopedics for their mechanical strength and cost-effectiveness.

6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression.

Neuropathy is a disturbance of function or a pathological change in nerves causing poor health and quality of life. A proportion of chronic pain patients in the community suffer persistent neuropathic pain symptoms because current drug therapies may be suboptimal so there is a need for new therapeutic modalities. This study investigated the neuroprotective flavonoid, 6-methoxyflavone (6MF), as a potential therapeutic agent and gabapentin as the standard comparator, against neuropathic models.

Tailoring NiCoCu layered double hydroxide with Ag-citrate/polyaniline/functionalized SWCNTs nanocomposites for supercapacitor applications.

Supercapacitors have substantially altered the landscape of sophisticated energy storage devices with their exceptional power density along with prolonged cyclic stability. On the contrary, their energy density remains low, requiring research to compete with conventional battery storage devices. This study addresses the disparities between energy and power densities in energy storage technologies by exploring the integration of layered double hydroxides (LDH) and highly conductive materials to develop an innovative energy storage system.

Circulation of foot-and-mouth disease serotypes, risk factors, and their effect on hematological and biochemical profiles among cattle and buffalo in Quetta, Balochistan, Pakistan.

Background And Aim: Foot-and-mouth disease (FMD) is an infectious disease of cloven-hoofed animals, including buffalo, cattle, sheep, goats, and pigs, causing major economic losses to the local farmers and, overall, to the national economy of the country. This study aimed to detect FMDV serotypes in year-round FMD outbreaks, hematological and biochemical changes, and oxidative stress in FMDV-infected cattle and buffaloes in the district of Quetta, Balochistan, Pakistan, and the socioeconomic impact of FMD outbreaks on farmers.

Materials And Methods: We conducted a cross-sectional study in the district of Quetta, Balochistan, Pakistan, where FMD virus (FMDV) serotypes were detected by enzyme-linked immunosorbent assay (ELISA).

Multitarget Mechanisms of Monocarbonyl Curcuminoid Analogues against HL-60 Cancer Cells: and Network Pharmacology-Based Approach.

This study addressed the cytotoxic potential of four compounds: monocarbonyl curcuminoid, ethyl (2E)-2-benzylidene-3-oxobutanoate , 1,2-dimethoxy-12-methyl-13H- [1,3] benzodioxolo[5,6-] phenanthridine , 3,5-dibenzyloxybenzyl bromide , and (E)-4-(4-chlorobenzylidene)-1-(4-nitrophenyl)hexan-3-one . cytotoxic assays were carried out in HL-60 and BJ cells using the MTT assay along with analysis of apoptosis with the annexin V detection kit. Additional network pharmacology and docking analyses were carried out.

Enhancing supercapacitor performance of Ni-Co-Mn metal-organic frameworks by compositing it with polyaniline and reduced graphene oxide.

Metal-organic frameworks (MOFs) are one of the most sought-after materials in the domain of supercapacitors and can be tailored to accommodate diverse compositions, making them amenable to facile functionalization. However, their intrinsic specific capacitance as well as energy density is minimal, which hinders their usage for advanced energy storage applications. Therefore, herein, we have prepared six electrodes, , Ni-Co-Mn MOFs, polyaniline (PANI), and reduced graphene oxide (rGO) along with their novel nanocomposites, , C, C, and C, comprising MOFs : PANI : rGO in a mass ratio of 100 : 1 : 0.

Synthetic dibenzylideneketones as promising anti-herpes simplex virus type 1 agents.

New antiviral agents for the treatment of herpes simplex virus type 1 (HSV-1) infection, which causes a highly prevalent and incurable disease, are needed. Here, we report for the first time the in vitro anti-HSV-1 activity of two dibenzylideneketone compounds: DBK1 and DBK2. DBK1 demonstrated virucidal activity, and high-resolution scanning electron microscopy showed that it caused morphological changes in the HSV-1 envelope.

Application of portable Vis-NIR spectroscopy for rapid detection of myoglobin in frozen pork.

Myoglobin content is considered as a crucial index to evaluate the quality of frozen pork. In this study, a portable visible and near-infrared (Vis-NIR) spectrometer combined with chemometrics was used to detect myoglobin content in frozen pork. Metmyoglobin, deoxymyoglobin, oxymyoglobin, and total myoglobin were assessed spectrophotometrically.

Dibenzylideneacetone Induces Apoptosis in Cervical Cancer Cells through Ros-Mediated Mitochondrial Damage.

Cervical cancer is a health problem among women worldwide. Considering the limitations of prevention and antineoplastic chemotherapy against cervical cancer, research is needed to discover new, more effective, and safe antitumor agents. In the present study, we investigated the in vitro cytotoxicity of a new synthetic dibenzylideneacetone derived from 1,5-diaryl-3-oxo-1,4-pentadienyl () against cervical cancer cells immortalized by HPV 16 (SiHa), and 18 (HeLa) by MTT assay.

Acid catalyzed one-pot approach towards the synthesis of curcuminoid systems: unsymmetrical diarylidene cycloalkanones, exploration of their single crystals, optical and nonlinear optical properties.

In the present study crystalline unsymmetrical diarylidene ketone derivatives BNTP and BDBC have been prepared by two sequential acid catalyzed aldol condensation reactions in a one pot manner. The crystal structures of both compounds were confirmed by single crystal X-ray diffraction analysis which revealed the presence of H-bonding interactions of type C-H⋯O, along with weak C-H⋯π and weak π⋯π stacking interactions that are involved in the crystal stabilization of both organic compounds. Hirshfeld surface analysis is carried out for the broad investigation of the intermolecular interactions in both compounds.

Synthesis, Structural, and Intriguing Electronic Properties of Symmetrical Bis-Aryl-α,β-Unsaturated Ketone Derivatives.

Three symmetrical bis-aryl--unsaturated ketone derivatives, 2,6-di(()-benzylidene)-cyclohexan-1-one (), 2,6-bis(()-4-chlorobenzylidene)cyclohexan-1-one (), and (1,1',4,4')-5,5'-(1,4-phenylene)bis(2-methyl-1-phenylpenta-1,4-dien-3-one) (), have been prepared using the aldol condensation approach toward ketones having two enolizable sites. The structures of , and have been resolved via spectrometric methods. Moreover, the crystal structure of is determined by the single-crystal X-ray diffraction (SC-XRD) technique, which revealed that the molecular assembly is stabilized by the intermolecular C-H···O bonding and C-O···π and weak T-shaped offset π···π stacking interactions.

Contamination level, source identification and health risk assessment of potentially toxic elements in drinking water sources of mining and non-mining areas of Khyber Pakhtunkhwa, Pakistan.

Accelerated mining activities have increased water contamination with potentially toxic elements (PTEs) and their associated human health risk in developing countries. The current study investigated the distribution of PTEs, their potential sources and health risk assessment in both ground and surface water sources in mining and non-mining areas of Khyber Pakhtunkhwa, Pakistan. Water samples (n = 150) were taken from selected sites and were analyzed for six PTEs (Ni, Cr, Zn, Cu, Pb and Mn).

Heat transfer analysis: convective-radiative moving exponential porous fins with internal heat generation.

The efficiency, temperature distribution, and temperature at the tip of straight rectangular, growing and decaying moving exponential fins are investigated in this article. The influence of internal heat generation, surface and surrounding temperatures, convection-conduction, Peclet number and radiation-conduction is studied numerically on the efficiency, temperature profile, and temperature at the tip of the fin. Differential transform method is used to investigate the problem.

Effect of Psyllium husk fiber and lifestyle modification on human body insulin resistance.

Insulin resistance is a metabolic disorder that is increasing worldwide and is associated with some of the most common diseases affecting modern societies including diabetes, hypertension, obesity, and coronary heart disease. Changes in diet and physical activity have a profound effect on lowering the risk and cost of managing insulin resistance compared to the pharmacological approach. An interventional study of 16 weeks explored the effect of Psyllium husk fiber in combination with lifestyle modification on insulin resistance among the centrally obese school teachers of district Malakand Khyber Pakhtunkhwa.

Non-Intrusive Load Monitoring of Buildings Using Spectral Clustering.

With widely deployed smart meters, non-intrusive energy measurements have become feasible, which may benefit people by furnishing a better understanding of appliance-level energy consumption. This work is a step forward in using graph signal processing for non-intrusive load monitoring (NILM) by proposing two novel techniques: the spectral cluster mean (SC-M) and spectral cluster eigenvector (SC-EV) methods. These methods use spectral clustering for extracting individual appliance energy usage from the aggregate energy profile of the building.

Takayasu Arteritis: Pattern Of Clinical And Radiological Features, Experience From Pakistan.

Background: Takayasu arteritis (TKA) is a rare large vessel vasculitis occurring in young adults of less than 50 year of age. We analyse the clinical, radiological features, and treatment regimens in Pakistani patients presenting to a tertiary care center.

Methods: A retrospective cross-sectional analysis of TKA patients done at the Rheumatology department of Fatima Memorial Hospital.

Clinical and serological characteristics of systemic sclerosis: Experience of a tertiary care center in Pakistan.

Objectives: This study aims to evaluate the clinical and serological characteristics of systemic sclerosis (SSc) in Pakistani population.

Patients And Methods: This prospective, cross-sectional study included a total of 38 patients (6 males, 32 females; mean age: 34.5±1.

Entropy generation from convective-radiative moving exponential porous fins with variable thermal conductivity and internal heat generations.

The performance and thermal properties of convective-radiative rectangular and moving exponential porous fins with variable thermal conductivity together with internal heat generation are investigated. The second law of thermodynamics is used to investigate entropy generation in the proposed fins. The model is numerically solved using shooting technique.

Breast Cancer Awareness and Associated Factors Amongst Women in Peshawar, Pakistan: A Cross-Sectional Study.

Background: Breast cancer is the most common cancer in women, and the second overall, following lung cancer. Breast cancer can occur at any age, with an increased incidence in women 40 years and above. Worldwide the incidence is around 1 million cases per year, 60% of the cases reported from low- and middle-income countries.

Occurrence, distribution, and pollution indices of potentially toxic elements within the bed sediments of the riverine system in Pakistan.

Potentially toxic elements (PTEs) are a major source of pollution due to their toxicity, persistence, and bio-accumulating nature in riverine bed sediments. The sediment, as the largest storage and source of PTEs, plays an important role in transformation of mercury (Hg), lead (Pb), nickel (Ni), chromium (Cr), copper (Cu), zinc (Zn), and other toxic PTEs. Several important industrial hubs that contain a large population along the banks of different rivers, such as Kabul, Sutlej, Ravi, Jhelum, and Chenab in Pakistan, are acting as major sources of PTEs.

The antioxidant N-(2-mercaptopropionyl)-glycine (tiopronin) attenuates expression of neuropathic allodynia and hyperalgesia.

The current pharmacotherapy of neuropathic pain is inadequate as neuropathic pain involves varied clinical manifestations with multifactorial etiology, modulated by a cascade of physical and molecular events leading to different clinical presentations of pain. There is an accumulating evidence of the involvement of oxidative stress in neuropathy, and antioxidants have shown promise in mitigating neuropathic pain syndromes. To explore the evidence supporting this beneficial proclivity of antioxidants, this study investigated the antinociceptive effectiveness of N-(2-mercaptopropionyl)glycine or tiopronin, a well-recognized aminothiol antioxidant, in a refined chronic constriction injury (CCI) rat model of neuropathic pain.

The flavonoid 6-hydroxyflavone prevention of cisplatin-induced nephrotoxicity.

In this study, the flavonoid, 6-hydroxyflavone was investigated for its renal protective activity in the cisplatin rat model of nephrotoxicity. Male Sprague-Dawley rats weighing 200-250 g were included in the study. 6-Hydroxyflavone was daily administered at 25 and 50 mg/kg (i.