Clinical characteristics, etiology, and treatment of young adult-onset epilepsy: A 24-year retrospective study.

Objective: To analyze the clinical characteristics, etiology, drug treatment, and related factors of patients with young adult-onset epilepsy.

Methods: The study included patients with epilepsy aged between 18 and 44 years and aimed to analyze the clinical characteristics of epilepsy in young people and their response to antiseizure medication (ASM) over a 24-year period (February 1999 and March 2023).

Results: A total of 4227 patients experienced epilepsy onset between 18 and 44 years of age.

Phytochemicals, promising strategies combating .

The excessive proliferation of is an important reason for the occurrence of acne vulgaris, and genetic detection ratio of in acne is as high as 60.5%. Until now, the treatment of is mainly limited to antibiotics, but some strains of produce antimicrobial resistances, making it difficult for clinical treatment.

Genome-wide analysis of the cotton COBRA-like gene family and functional characterization of GhCOBL22 in relation to drought tolerance.

Background: The COBRA-like (COBL) gene family is a crucial glycosylphosphatidylinositol (GPI)-anchored proteins that participate in various biological processes in plants by regulating the arrangement of cell wall microfibrils. While the functions of COBL genes have been analyzed in several plant species, their roles in cotton's response to abiotic stress remain unexplored.

Results: This study identified and characterized the COBL gene family in Gossypium hirsutum, revealing a total of 39 COBL family members classified into five subgroups.

Improvement of maize starch-lauric acid complexes by plasma pretreatment: Formation, structure, properties and its related mechanisms.

Starch-lipid complexes have attracted widespread attention owing to high anti-digestibility and thermal stability. However, methods to increase the content of starch-lipid complexes are limited. Therefore, this study aims to investigate the effect of atmospheric cold plasma (ACP) treatment for different times (0, 1, 3, 5, and 7 min) on the formation and structure of complexes between maize starch (MS) and lauric acid (LA).

Numerical study of the effects of minor structures and mean velocity fields in the cerebrospinal fluid flow.

The importance of optimizing intrathecal drug delivery is highlighted by its potential to improve patient health outcomes. Findings from previous computational studies, based on an individual or a small group, may not be applicable to the wider population due to substantial geometric variability. Our study aims to circumvent this problem by evaluating an individual's cycle-averaged Lagrangian velocity field based on the geometry of their spinal subarachnoid space.

Risk factors for complications of Mycoplasma pneumoniae pneumonia in hospitalized children in China: a systematic review and meta-analysis.

Background: Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory disease in children. Some patients may develop long-term respiratory issues such as chronic cough and wheezing due to complications. These complications increase the health burden for children with MPP, highlighting the need to understand their risk factors in order to improve disease prognosis.

AcGLK1 promotes chloroplast division through regulating AcFtsZ1 in Actinidia chinensis.

This study unravels a new regulatory member (AcGLK1) that regulates chloroplast division by affecting the expression levels of cytoskeletal filamenting temperature-sensitive Z (FtsZ) in Actinidia chinensis. GOLDEN 2-LIKE (GLK) transcription factor members of GARP subfamily play an irreplaceable role in regulating chloroplast biogenesis and development. Here we report the functional characterization of a novel GLK1 homolog (AcGLK1) isolated from kiwifruit (Actinidia chinensis cultivar 'Hongyang').

Energy Management Strategy for Fuel Cell Vehicles Based on Online Driving Condition Recognition Using Dual-Model Predictive Control.

Given the urgent challenges posed by global climate change and the ongoing energy crisis, fuel cell electric vehicles (FCEVs) have emerged as a promising solution. Incorporating sophisticated energy management strategies (EMSs) into FCEVs can significantly enhance the efficiency of the complex powertrain under diverse driving conditions. In this paper, a dual-model predictive control energy management strategy based on long short-term memory (LSTM)-based driving condition recognition is proposed to enhance the economic performance of FCEVs and robustness across diverse driving conditions.

Twelve Shugan Lidan Granules from traditional Chinese medicine can improve liver function in patients with postoperative hepatolithiasis by inhibiting the Hippo signaling pathway.

Introduction: Hepatolithiasis (HL) is a complex liver and biliary disorder characterized by high rates of recurrence. This study aimed to evaluate the efficacy of Twelve Shugan Lidan Granules (TSLG), a compound herbal traditional Chinese formulation, in the treatment of HL, as well as to investigate its underlying mechanism.

Methods: A retrospective analysis was conducted involving 157 patients diagnosed with HL, who were divided into two groups: the control group and the research group.

The association between child maltreatment and academic achievement: A systematic review and meta-analysis.

Background: Although the association between child maltreatment and academic performance has been well-established, the magnitude of these associations remains unclear.

Objective: This study aims to summarize the associations between child maltreatment and its subtypes (physical, emotional, sexual abuse, and neglect) and academic achievement (general achievement, language arts, and math) as well as to explore potential moderators.

Participants And Setting: This present meta-analysis included 59 studies with 211,568 participants, of which 50.

3D printing of drug delivery systems enhanced with micro/nano-technology.

Drug delivery systems (DDSs) are increasingly important in ensuring drug safety and enhancing therapeutic efficacy. Micro/nano-technology has been utilized to develop DDSs for achieving high stability, bioavailability, and drug efficiency, as well as targeted delivery; meanwhile, 3D printing technology has made it possible to tailor DDSs with diverse components and intricate structures. This review presents the latest research progress integrating 3D printing technology and micro/nano-technology for developing novel DDSs.

Fabrication of oxygen-vacancy abundant NiAl-layered double hydroxides for ultrahigh capacity supercapacitors.

The manipulation of oxygen vacancies is regarded as a viable approach to enhance the electrochemical properties of electrode materials. Herein, NiAl-LDH nanosheets with rich oxygen vacancies were successfully synthesized on the surface of nickel foam a conventional hydrothermal and chemical reduction strategy. The oxygen vacancies were introduced and modulated NaBH treatment, significantly enhancing the electrochemical properties.

miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades.

Introduction: Fibroblast abnormalities are crucial causes of skin fibrosis, including systemic sclerosis (SSc) and keloids. However, their mechanisms, including underlying microRNA regulatory mechanisms, remain elusive.

Objectives: This study aimed to evaluate the roles, mechanisms, and therapeutic potential of miR-3606-3p in regulating multiple fibroblast abnormalities.

Effectiveness of treat-to-target cholesterol-lowering interventions on cardiovascular disease and all-cause mortality risk in the community-dwelling population: a target trial emulation.

Little is known about the long-term effectiveness of risk-based treat-to-target cholesterol-lowering interventions on cardiovascular risk. Here, we show the emulated effectiveness of guideline-recommended low-density and non-high-density lipoprotein cholesterol-lowering interventions using the absolute risk reduction (ARR) and the restricted mean event-free time-based number needed to treat (NNT). With 5,375 participants, the 29-year risks for cardiovascular disease (CVD), all-cause mortality, and atherosclerotic CVD were 18.

Altered intrinsic neural activity and its molecular analyses in first-episode schizophrenia with auditory verbal hallucinations.

Background: Auditory verbal hallucinations (AVHs) are one of the signature positive symptoms of schizophrenia, affecting a substantial portion of patients with schizophrenia. These hallucinations seriously impact the lives of patients, resulting in a substantial social burden. Recent studies have shown a significant correlation between abnormal local brain activity and the neurobiological mechanisms of AVHs.

Effects of Creatine Supplementation and Resistance Training on Muscle Strength Gains in Adults <50 Years of Age: A Systematic Review and Meta-Analysis.

Background: Numerous meta-analyses have assessed the efficacy of creatine supplementation in increasing muscle strength. However, most have not considered the effect of the participants' age, training duration, or other confounding variables on strength outcomes. Therefore, the purpose of this study was to consider the effect of these variables on the potential efficacy of creatine supplementation and resistance training for improving measures of muscle strength.

Deep Incomplete Multi-view Clustering via Multi-level Imputation and Contrastive Alignment.

Deep incomplete multi-view clustering (DIMVC) aims to enhance clustering performance by capturing consistent information from incomplete multiple views using deep models. Most existing DIMVC methods typically employ imputation-based strategies to handle missing views before clustering. However, they often assume complete data availability across all views, overlook potential low-quality views, and perform imputation at a single data level, leading to challenges in accurately inferring missing data.

Ultrasound-Assisted Remote Benzylic C(sp)-H Alkylation of -Fluoroamides with Enol Silanes.

We have developed an ultrasound-assisted remote benzylic C(sp)-H alkylation of -fluorobenzamides with enol silanes; a series of β-aryl substituted propiophenones was generated in good to high yields. This reaction represents a C(sp)-C(sp) coupling and features simplicity, high efficiency, and wide substrate scope in a multiple-step sequential process, which involves N-F homolysis, 1,5-hydrogen atom transfer, benzylic radical addition, oxidation by copper(II) salt, and removal of the trimethylsilyl group. Also, DFT theoretical calculations and Marcus theory were employed to consolidate the proposed reaction mechanism.

Differential proteomic profiles of exosomes in pediatric and adult adamantinomatous craniopharyngioma cyst fluid.

Background: Adamantinomatous craniopharyngiomas (ACPs), commonly seen in pediatrics and adults often present with large cystic cavities that can compress surrounding tissues, causing severe visual and endocrine symptoms. Complete resection of cystic ACP is challenging, frequently leading to postoperative recurrence. The composition of the cystic fluid is complex, and to date, there has been limited research focusing on exosomes within ACP cyst fluid.

Determination of aflatoxin B1 in wheat using Raman spectroscopy combined with chemometrics.

Aflatoxin B1 (AFB1) is carcinogenic and highly susceptible to production in wheat. In this study, the quantitative detection of contaminant AFB1 in wheat was investigated by Raman spectroscopy combined with chemometric method realization. Firstly, Savitzky-Golay smoothing (SG) and baseline calibration methods were used to perform the necessary preprocessing of the collected raw Raman spectra.

The influence of neuroticism on insomnia: The chain mediating effect of mind wandering and symptom rumination.

Background: Insomnia is a major public health issue worldwide. An association between neuroticism and insomnia has been widely confirmed, but its psychological mechanisms are unclear.

Methods: A total of 1790 online participants completed the Big Five Personality Inventory, Athens Insomnia Scale, Chinese version of the Mind Wandering Questionnaire, and Chinese version of the Nolen-Hoeksema Ruminative Responses Scale.