Cervical Defect Reconstruction Using Preexpanded Neck Flaps Transferred in a Scarf-wrapping Manner.

Objective: Cervical burn scar contractures can be repaired using many modalities, including skin grafts, pedicled and free flaps. Although preexpanded cervical flaps can provide a like-with-like reconstruction, a simple advancement transfer of the flaps often fails to achieve ideal outcomes. The authors aimed to introduce a method using the preexpanded cervical flaps transferred in a scarf-wrapping manner to repair neck defects.

A network analysis of depression and anxiety symptoms among Chinese elderly living alone: based on the 2017-2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS).

Background: Elderly individuals living alone represent a vulnerable group with limited family support, making them more susceptible to mental health issues such as depression and anxiety. This study aims to construct a network model of depression and anxiety symptoms among older adults living alone, exploring the correlations and centrality of different symptoms. The goal is to identify core and bridging symptoms to inform clinical interventions.

PAH-Finder: A Pattern Recognition Workflow for Identification of PAHs and Their Derivatives.

Polycyclic aromatic hydrocarbons (PAHs) are pervasive environmental pollutants with significant health risks due to their carcinogenic, mutagenic, and teratogenic properties. Traditional methods for PAH identification, primarily relying on gas chromatography-mass spectrometry (GC-MS), utilize spectral library searches together with other techniques, such as mass defect analysis. However, these methods are limited by incomplete spectral libraries and a high false positive rate.

Genome-Wide Identification and Expression Analysis of Gene Family Members in Seashore Paspalum Under Salt Stress.

The gene family plays a crucial role in plant growth, development, and responses to biotic and abiotic stresses. , a warm-season turfgrass with exceptional salt tolerance, can be irrigated with seawater. However, the gene family in seashore paspalum remains poorly understood.

Mechanisms of gut homeostasis regulating Th17/Treg cell balance in PMOP.

Postmenopausal osteoporosis (PMOP) is a metabolic bone disease driven by estrogen deficiency, primarily manifesting as reduced bone mass and heightened fracture risk. Its development is intricately linked to the balance between Th17 and Treg cells. Recent studies have highlighted the significant role of gut homeostasis in PMOP.

Sensing Technologies for Outdoor/Indoor Farming.

To face the increasing requirement for grains as the global population continues to grow, improving both crop yield and quality has become essential. Plant health directly impacts crop quality and yield, making the development of plant health-monitoring technologies essential. Variable sensing technologies for outdoor/indoor farming based on different working principles have emerged as important tools for monitoring plants and their microclimates.

Combining stable isotopes and multi-elements with machine learning chemometric models to identify the geographical origins of Tetrastigma hemsleyanum Diels et Gilg.

Tetrastigma hemsleyanum Diels et Gilg (T. hemsleyanum) is an edible plant with considerable medicinal properties, the quality of which varies depending on its origin. Therefore economically motivated adulteration has emerged.

Frailty and the risk of age-related macular degeneration: a prospective cohort and Mendelian randomization study.

Background: Both frailty and age-related macular degeneration (AMD) are related to aging and may share some common mechanisms. We aimed to examine the observational and causal association between frailty and the risk of age-related macular degeneration (AMD).

Methods: We included 320,810 participants free of AMD at baseline from the UK Biobank.

Triboelectric Mat Multimodal Sensing System (TMMSS) Enhanced by Infrared Image Perception for Sleep and Emotion-Relevant Activity Monitoring.

To implement digital-twin smart home applications, the mat sensing system based on triboelectric sensors is commonly used for gait information collection from daily activities. Yet traditional mat sensing systems often miss upper body motions and fail to adequately project these into the virtual realm, limiting their specific application scenarios. Herein, triboelectric mat multimodal sensing system is designed, enhanced with a commercial infrared imaging sensor, to capture diverse sensory information for sleep and emotion-relevant activity monitoring without compromising privacy.

Deciphering the inhibition mechanisms of microplastics on the full-stage sludge anaerobic digestion via enrichment to anaerobic microbes and toxicity of released compounds.

Increasingly accumulated microplastics (MPs) in sludge could affect the sludge treatment process, while the contributions and mechanisms of MP particles and the released organic matters (MP-DOM) are not fully understood. To fill this gap, this study systematically investigates the effects and mechanisms of MPs on sludge anaerobic digestion. In the presence of MPs, the hydrolysis and acidogenesis of organic matters and methanogenesis all decreased due to the inhibition on the activity of anaerobic microorganisms and key enzymes.

Enrichment of Nanoplastics in Waters Using Magnetic Solid Phase Extraction With Magnetic Biochar Adsorbents and Their Determination by Pyrolysis Gas Chromatography-Mass Spectrometry.

Nanoplastics (NPs) are emerging water contaminants that threaten human health and ecological security. Developing a method for detecting NPs is significant because of their biological toxicity and mobility. In this study, magnetic solid-phase extraction (MSPE) combined with pyrolysis gas chromatography-mass spectrometry (Py-GC/MS) was used for the pretreatment and qualitative detection of NPs in complex matrices to avoid sample dissolution and eluent usages.

Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I.

Background And Aims: Atherosclerotic cardiovascular diseases are the leading cause of death. Apolipoprotein A-I (apoA-I) mediates cholesterol efflux to lower the risks of atherosclerosis. Elevating circulating apoA-I is an effective strategy for atheroprotection.

Major Bleeding and Mortality After Revascularization of Left Main Disease.

Background: The incidence and prognostic impact of major bleeding (MB) after percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) are unknown.

Objectives: The goal of this study was to investigate the rates and outcomes of MB after LMCAD revascularization.

Methods: In the EXCEL (Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial, 1,905 patients with unprotected LMCAD were randomized to undergo PCI (n = 948) or CABG (n = 957) and followed up for 5 years.

Long-term iodine deficiency and excess inhibit β-casein and α-lactalbumin secretion of milk in lactating rats.

Iodine is critical for thyroid hormone synthesis and developmental programming in the first 1,000 days of life. The effect of maternal iodine on milk protein secretion remains unknown. We aimed to explore the effect of long-term maternal iodine deficiency and excess on milk protein secretion in lactating rats and its mechanisms preliminarily.

A hyaluronic acid-based dual-functional hydrogel microneedle system for sequential melanoma ablation and skin regeneration.

Melanoma treatment remains a challenge due to the inadequacy of existing clinical approaches and the difficulty of tissue regeneration. Recently, microneedles have been widely studied in tumor therapy and skin repair. Hence, a hyaluronic acid (HA)-based dual-functional hydrogel microneedle (MN) system was constructed to sequentially achieve tumor ablation and skin regeneration.

Deciphering the electronic and structural origin of chiroptical activity of chiral 2D perovskites.

Understanding the structure-chiroptical activity relationship in chiral perovskites is of great significance as it provides a pathway to control light-matter interactions. Although many reports have shown various chiral structures with distinctive chiroptical responses, a clear structure-property relationship is still missing, partially stemming from the poor understanding of the optical activity mechanism. For instance, it remains unclear if and how the chiroptical activity is related to exciton spin splitting.

Branched-chain amino acid catabolism promotes M2 macrophage polarization.

Introduction: During an immune response, macrophages undergo systematic metabolic rewiring tailored to support their functions. Branched-chain amino acid (BCAA) metabolism has been reported to modulate macrophage function; however, its role in macrophage alternative activation remain unclear. We aimed to investigate the role of BCAA metabolism in macrophage alternative activation.

Transcutaneous auricular vagal nerve stimulation modulates blood glucose in ZDF rats via intestinal melatonin receptors and melatonin secretion.

Background: Melatonin (MLT) and its receptor deficiency have been shown to be associated with type 2 diabetes mellitus (T2DM). Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive alternative intervention for patients suffering from hyperglycemia. Here, we aimed to investigate the role of taVNS on blood glucose modulation via intestinal melatonin receptors (MRs) and MLT secretion in hyperglycemia.

Integrative network pharmacology and multi-omics to study the potential mechanism of Niuhuang Shangqing Pill on acute pharyngitis.

Ethnopharmacological Relevance: Niuhuang Shangqing Pill (NSP) is a renowned Chinese medicine prescription listed in the Chinese Pharmacopoeia (Edition, 2020; volume 1) and is utilized in clinical practice for treating headaches and acute pharyngitis (AP) associated with "Shanghuo". Despite its widespread use, the pharmacological mechanism and bioactive components underlying NSP in treating AP remain unclear.

Aim Of The Study: This study delved into evaluate the alleviation effect of NSP on AP and explore the mechanisms by analyzing multi-omics.

Effective strategy for properly evaluating the relative sensitivity of luminescence thermometry.

Over the past few years, luminescence thermometry has been a hot research topic for its non-contact operating mode, high temporal and spatial resolution, and so forth. For luminescence thermometry, relative sensitivity is one of the most important parameters. However, this parameter has been wrongly presented in a lot of literatures.