Restrain Phase Segregation by In Situ Buried Prenucleation for Efficient and Stable Wide-Band Gap Perovskite Cells.

The phase segregation of wide-band gap perovskite solar cells (PSCs) typically originates from defect centers and strain induced by nonstoichiometric compounds. In this study, we have discovered an excess of PbI at the buried interface in inverted wide-band gap PSCs. To address this issue, RbI is introduced to interact with the excessive PbI, thereby in situ forming a layer of inorganic perovskite RbPbI.

USP37-stabilized SALL4 promotes the keloid formation by PI3K/AKT pathway.

Spalt-like transcription factor 4 (SALL4) plays a vital role in the progression of many human diseases. However, the role and mechanism of SALL4 regulates in keloid formation remain unclear. The mRNA levels of SALL4 and ubiquitin-specific peptidase 37 (USP37) in keloid tissues and keloid fibroblasts were determined by quantitative real-time PCR.

The efficacy of miR-141-3p to facilitate the healing of wounds and prevent scarring in mice by blocking the JNK/ERK pathway via HDAC6 silencing.

Purpose: Adipose-derived mesenchymal stem cells (ADSCs) exosomes (AD-Exos) are a novel and promising therapeutic approach for skin damage repair. This investigation seeks to assess the potential clinical utility of miR-141-3p found in AD-exos for expediting wound healing.

Methods: ADSCs were isolated from the wounded patients' tissue and validated via flow cytometry, and the mineralization and adipogenic capabilities of ADSCs were assessed respectively.

The reaction mechanisms of ethylene oxide and propylene oxide with food Simulants: Based on experiments and computational analysis.

Ethylene oxide (EO) and propylene oxide (PO) are widely used as sterilizing agents in the food industry. However, their residues in food packaging can migrate into food and react with it, affecting the accuracy of residue detection in food. This study aims to explore the reaction mechanisms between EO and PO and aqueous food simulants using both experimental and computational methods.

Enhanced Light Transmittance of Electron Transport Layer through Bilayer SnO for High-Performance Semitransparent Perovskite Solar Cells.

Semitransparent perovskite solar cells (ST-PSCs) for building-integrated photovoltaics (BIPV) face the challenge of achieving high efficiency due to significant light loss. The SnO electron transport layer (ETL), utilized in n-i-p PSCs and prepared via the sol-gel method, is susceptible to aggregation on substrate, resulting in light scattering that diminishes absorption of the perovskite layer. In this study, we propose a strategy that combines atomic layer deposition (ALD) and sol-gel solution to deposit a bilayer SnO structure to address these issues.

Fractional order system identification using a joint multi-innovation fractional gradient descent algorithm.

This paper proposes a joint multi-innovation fractional gradient descent identification algorithm for fractional order systems. First, the flexibility of fractional calculus is leveraged to design a joint fractional gradient descent algorithm capable of estimating system parameters and unknown orders. The estimated system parameters are used as the initial conditions to identify the unknown order, and the identified order is used as the update conditions for the system parameters.

Combining computed tomography features of left atrial epicardial and pericoronary adipose tissue with the triglyceride-glucose index to predict the recurrence of atrial fibrillation after radiofrequency catheter ablation: a machine learning study.

Background: Radiofrequency catheter ablation (RFCA) represents an important treatment option for atrial fibrillation (AF); however, the recurrence rate following surgery is relatively high. This study aimed to predict the recurrence of AF after RFCA using interpretable machine learning models that combined the triglyceride-glucose (TyG) index and the quantification of left atrial epicardial and pericoronary adipose tissue.

Methods: This retrospective study included 325 patients with AF who underwent their first successful RFCA, among whom 79 had confirmed recurrence.

Injectable and adhesive MgO-potentiated hydrogel with sequential tumor synergistic therapy and osteogenesis for challenging postsurgical osteosarcoma treatment.

The clinical treatment of osteosarcoma faces great challenges of residual tumor cells leading to tumor recurrence and irregular bone defects difficult to repair after surgery removal of the primary tumor tissue. We developed an injectable and in-situ cross-linkable hydrogel (named MOG hydrogel) using MgO nanoparticles and dopamine-conjugated gelatin as main components. MgO was rationally designed as a multifunctional active ingredient to mediate in situ gelation, tumor therapy, and bone repair sequentially.

GelMA-based moldable and rapid-curable osteogenic paste inspired by ceramic craft for alveolar bone defect regeneration.

Alveolar bone defects pose a significant challenge in oral clinical treatments, impacting procedures such as dental implants, orthodontics, and oral restoration. Despite their frequent occurrence due to various causes, the effective restoration and reconstruction of alveolar bone defects remain a significant clinical challenge in dentistry. Existing treatments often rely on intrinsic blood coagulation to stabilize bone grafts, but they present limitations such as gradual clotting and reduced effectiveness in patients with coagulation dysfunction.

Additional fractional gradient descent identification algorithm based on multi-innovation principle for autoregressive exogenous models.

This paper proposed the additional fractional gradient descent identification algorithm based on the multi-innovation principle for autoregressive exogenous models. This algorithm incorporates an additional fractional order gradient to the integer order gradient. The two gradients are synchronously used to identify model parameters, thereby accelerating the convergence of the algorithm.

To elucidate the mechanism of "Scrophulariae Radix-Fritillaria" in goiter by integrated metabolomics and serum pharmaco-chemistry.

The pharmacodynamic substances in "Scrophulariae Radix-Fritillaria" and the molecular mechanisms underlying its therapeutic effects against goiter were analyzed through metabolomics and serum pharmaco-chemistry. A rat model of goiter was established using propylthiouracil (PTU), and the animals were treated using "Scrophulariae Radix-Fritillaria." The efficacy of the drug pair was evaluated in terms of thyroid gland histopathology and blood biochemical indices.

Bioinspired polysaccharide-based nanocomposite membranes with robust wet mechanical properties for guided bone regeneration.

Polysaccharide-based membranes with excellent mechanical properties are highly desired. However, severe mechanical deterioration under wet conditions limits their biomedical applications. Here, inspired by the structural heterogeneity of strong yet hydrated biological materials, we propose a strategy based on heterogeneous crosslink-and-hydration (HCH) of a molecule/nano dual-scale network to fabricate polysaccharide-based nanocomposites with robust wet mechanical properties.

Harmonizing Thickness and Permeability in Bone Tissue Engineering: A Novel Silk Fibroin Membrane Inspired by Spider Silk Dynamics.

Guided bone regeneration gathers significant interest in the realm of bone tissue engineering; however, the interplay between membrane thickness and permeability continues to pose a challenge that can be addressed by the water-collecting mechanism of spider silk, where water droplets efficiently move from smooth filaments to rough conical nodules. Inspired by the natural design of spider silk, an innovative silk fibroin membrane is developed featuring directional fluid transportation via harmoniously integrating a smooth, dense layer with a rough, loose layer; conical microchannels are engineered in the smooth and compact layer. Consequently, double-layered membranes with cone-shaped microporous passageways (CSMP-DSF membrane) are designed for in situ bone repair.

Core Target and Key Signal Pathway of Xiaoluo in the Treatment of Thyroid Cancer.

Context: At present, hormone therapy and surgery are the main treatments for thyroid cancer, and they have a quick effect but a high recurrence rate. Also, the side effects are significant. it's extremely urgent to explore treatments that can take into account both therapeutic benefits and side effects.

Stability Boundary and Enhanced Solution of Dual-Mode Based Micro Gyroscope Mode Matching Technology.

During in-run mode matching under a dual-mode gyro scheme, the stability of the closed-loop control system has a boundary. This phenomenon will lead to the failure of the in-run frequency split calibration scheme when the initial mode mismatch is too severe to exceed the stability boundary. This paper gives a detailed analysis of this stability boundary through simulations and experiments.

Liquid crystal spatial light modulator based non-mechanical beam steering system fractional-order model.

The liquid crystal spatial light modulator (LCSLM) is an optical device that can realise non-mechanical beam scanning. However, the traditional integer-order model cannot adequately characterise the dynamic performance of LCSLM beam steering because of the viscoelasticity of liquid crystals. This paper uses the memory characteristics of fractional calculus to construct a fractional constitutive equation for liquid crystals.

Intestinal Microbial Diversity of Free-Range and Captive Yak in Qinghai Province.

Background: The gut microbiome is a large and complex organic assemblage with subtle and close relationships with the host. This symbiotic mechanism is important for the health and adaptability of the host to the environment. Compared with other ruminants, there are few studies on yak intestinal microbes.

Orf Virus Detection in the Saliva and Milk of Dairy Goats.

Orf is a zoonotic and highly contagious disease caused by Orf virus (ORFV) infection. Orf outbreaks in sheep and goats usually lead to high culling rate and mortality in newborn kids and lambs, posing a great threat to the development of goat and sheep industry. Human Orf occurs direct contact with infected animals or fomites.

Diffraction characteristics of a non-mechanical beam steering system with liquid crystal polarization gratings.

The non-mechanical beam steering system is composed of multiple liquid crystal polarization gratings (LCPGs) cascaded by binary or ternary technologies. However, cascading multiple LCPGs cause the beam from one LCPG to obliquely enter the subsequent LCPGs, changing their diffraction efficiency and working voltage at different steering angles. This paper uses the elastic continuum theory of liquid crystals to simulate the tilt angle of liquid crystal molecules under different voltages.

Bone Graft Materials for Alveolar Bone Defects in Orthodontic Tooth Movement.

Clinically, orthodontic tooth movement (OTM) across the narrow alveolar ridge area inevitably entails some adverse reactions such as limited movement and periodontal tissue damage. Hence, it is essential to reconstruct the morphology of the alveolar crest before the tooth movement. Unlike the routine reconstruction of alveolar ridge in the field of implant, the orthodontic practices are distinctive, which require dental movement across the constructed alveolar ridge with safety and stability.

Regio- and Stereoselective Synthesis of Highly Functionalized Tetrasubstituted Olefins by Iodine-Mediated Iodofunctionalization of Ferrocene-Containing Allenylphosphonates.

An iodine-mediated iodofunctionalization of ferrocene-containing allenylphosphonates with various carboxylic acids, alcohols, and phenols has been established, affording a series of highly functionalized tetrasubstituted alkenylphosphonate derivatives with high regio- and stereoselectivities in moderate to good yields. This approach provides an opportunity to the useful but not readily available tetrasubstituted olefins. The stereoselectivity of the reaction may be controlled by the neighboring group participation of the oxygen atom of the phosphate group.

Tourmaline-Modified FeMnTiO Catalysts for Improved Low-Temperature NH-SCR Performance.

Low temperature NH selective catalytic reduction (NH-SCR) technology is an efficient and economical strategy for cutting NO emissions from power-generating equipment. In this study, a novel and highly efficient NH-SCR catalyst, tourmaline-modified FeMnTiO is presented, which was synthesized by a simple one-step sol-gel method. We found that the amount of tourmaline has an important impact on the catalytic performance of the modified FeMnTiO -based catalysts, and the NO conversion exceeded 80% from 160 to 380 °C with the addition of 5 wt % tourmaline.

Autophagy Induction Ameliorates Inflammatory Responses in Intestinal Ischemia-Reperfusion Through Inhibiting NLRP3 Inflammasome Activation.

Intestinal ischemia/reperfusion (I/R)-induced systemic inflammation leads to multiple organ dysfunction syndrome. Previous studies have indicated that the NOD-like receptor protein (NLRP)3 inflammasome modulates intestinal inflammation; however, the pathophysiological mechanisms remain unclear. Autophagy is a critical metabolic mechanism that promotes cellular survival following ischemic injury.