Identification and characterization of anthocyanins' composition and regulatory genes involved in anthocyanins biosynthesis in water dropwort (Oenanthe javanica).

This study showed that anthocyanin was the main pigments related to purple stem and OjUFGT1 is involved in anthocyanin glycosylation in water dropwort. Water dropwort is a kind of aquatic vegetable with many medicinal values. In the study, the green-stem water dropwort 'FQ1H' and purple-stem water dropwort 'Sq013' were selected as plant materials.

Carbon source dosage intelligent determination using a multi-feature sensitive back propagation neural network model.

The carbon reduction concept drives the development of low-carbon and sustainable wastewater treatment plant (WWTP) operation technologies. In the denitrification stage of WWTPs in China, there are widespread problems of uneconomical dosage consumption and unstable total nitrogen (TN) concentration in effluent through manual experience to add external carbon sources. Deep learning methods can deal with these problems.

Identifying a Biocontrol Bacterium with Disease-Prevention Potential and Employing It as a Powerful Biocontrol Agent Against .

Biocontrol microbes are environment friendly and safe for humans and animals. To seek biocontrol microbes effective in suppressing is important for tomato production. is a soil-borne pathogen capable of causing wilt in numerous plant species.

Electrochemical deposition of bimetallic sulfides on novel BDD electrode for bifunctional alkaline seawater electrolysis.

Seawater electrolysis is an ideal technology for obtaining clean energy-green hydrogen. Developing efficient bifunctional catalysts is crucial for hydrogen production through direct seawater electrolysis. Currently, metal substrates loaded with active catalysts are widely employed as electrodes for seawater electrolysis.

PSTK exerts protective role in cisplatin-tubular cell injury via BAX/BCL2/Caspase3 pathway.

Cisplatin is a widely used anticancer drug, but its accumulation in renal tubular epithelial cells (TECs) can cause acute kidney injury. Phosphoseryl-tRNA kinase (PSTK) is an intermediate product produced under oxidative stress conditions. This study aimed to elucidate whether PSTK could protect TECs and its possible mechanisms.

Vitamin K intake levels are associated with bone health in people aged over 50 years: a NHANES-based survey.

Background: Bone health is important for older adults, and vitamin K (VK) is central to regulating bone formation and promoting bone health. However, whether VK can reduce the risk of osteoporosis and bone loss is unclear. This study hypothesized that different levels of VK intake exert varying effects on bone health in people aged over 50 years.

Transformation of Natural Organic Matter in Simulated Abiotic Redox Dynamic Environments: Impact on Fe Cycling.

Redox fluctuations within redox dynamic environments influence the redox state of natural organic matter (NOM) and its interaction with redox-active elements, such as iron. In this work, we investigate the changes in the molecular composition of NOM during redox fluctuations as well as the impact of these changes on the Fe-NOM interaction employing Suwannee River Dissolved Organic Matter (SRDOM) as a representative NOM. Characterization of SRDOM using X-ray photoelectron spectroscopy and Fourier transform infrared spectrometry showed that irreversible changes occurred following electrochemical reduction and reoxidation of SRDOM in air.

Impact of neighborhood-level COVID-19 mortality on the increase in drug overdose mortality in New York City during the COVID-19 pandemic.

Background: Overdose mortality increased substantially during the COVID-19 pandemic, but it is unclear to what extent the COVID-19 mortality had contributed to this increase at the neighborhood level.

Methods: This was an ecological study based on New York City United Hospital Fund (NYC UHF) neighborhood-level data from 2019 to 2021, split into two time-windows: pre-COVID (2019) and during-COVID (2020 and 2021). Linear regression models were used to estimate the effect of cumulative COVID-19 mortality on the increase in drug overdose mortality from the pre-COVD to during-COVID periods at the neighborhood level, with and without adjusting for neighborhood characteristics.

Comparative analysis of free SMAS fold flap and ADM in facial depression after parotidectomy.

Background: This study aimed to analyze the effects of anterior descending mandible (ADM) and free superior mesenteric artery (SMAS) folding flaps on post-parotidectomy facial depression.

Methods: This retrospective study examined the effects of sex, age, surgical sample size, method, duration, and blood loss on postoperative complications in 65 patients.

Results: No significant differences involving sex, age, or sample size for surgical resection were observed between the two groups.

Numerical Simulation and Experimental Analysis for Microwave Sintering Process of Lithium Hydride (LiH).

Dense lithium hydride (LiH) is widely used in neutron shielding applications for thermonuclear reactors and space systems due to its unique properties. However, traditional sintering methods often lead to cracking in LiH products. This study investigates the densification sintering of LiH using microwave technology.

Evaluating the burden of illness of metabolic dysfunction-associated steatohepatitis in a large managed care population: The ETHEREAL Study.

Background: Metabolic dysfunction-associated steatohepatitis (MASH; formerly nonalcoholic steatohepatitis) is the inflammatory form of metabolic dysfunction-associated steatotic liver disease (formerly nonalcoholic fatty liver disease). MASH is a progressive disease associated with increased risk for many hepatic and extra-hepatic complications such as cirrhosis, hepatocellular carcinoma, the requirement for liver transplantation, and cardiovascular (CV)-related and kidney-related complications. It is important to understand the clinical and economic burden of MASH.

β-GaO Nanoribbon with Ultra-High Solar-Blind Ultraviolet Polarization Ratio.

Solar-blind ultraviolet (UV) detection plays a critical role in imaging and communication due to its low-noise background, high signal-to-noise ratio, and strong anti-interference capabilities. Detecting the polarization state of UV light can enhance image information and expand the communication dimension. Although polarization detection is explored in visible and infrared light, and applied in fields such as astrophysics and submarine seismic wave detection, solar-blind UV polarization detection remains largely unreported.

Carboxymethyl chitosan/polyacrylamide double network hydrogels based on hydrogen bond cross-linking as potential wound dressings for skin repair.

An ideal biomedical hydrogel should imitate natural tissues with high water absorption, high toughness and superior biocompatibility. However, hydrogels constructed from biomolecules such as polysaccharides have low mechanical strength and limited applications. Based on carboxymethyl chitosan (CMCS) and polyacrylamide (PAM), a facile process is presented for preparing double network hydrogels (CMCS/PAM) with improved mechanical properties.

LNP-mRNA vaccine prevents type 1 diabetes in non-obese diabetes mice.

Islet-antigen-specific tolerization is a key goal of experimental immunotherapies for type 1 diabetes. mRNA-based vaccines have demonstrated the feasibility of RNA delivery in inducing antigen tolerance in autoimmune diseases. In this study, mRNA vaccine, encoded tandem glutamic acid decarboxylase 65 (GAD65) epitopes and cholera toxin B subunit (CTB-GADIII), prepared by an in vitro transcription (IVT) system and encapsulated with lipid nanoparticles (LNP), was intramuscularly administered to non-obese diabetic (NOD) and cyclophosphamide (Cy)-NOD mice respectively.

Enhanced pendulum appliance utilizing temporary anchorage device-based Nance arch and modified springs for optimized molar distalization control: a case report.

A 20-year-old female patient with severe maxillary crowding and skeletal Class III malocclusion was successfully treated using an enhanced pendulum appliance. Camouflage treatment was chosen because the patient refused surgical intervention. Detailed examination and analysis revealed that labial inclination of the maxillary anterior teeth could provide the alignment space necessary after tooth extraction in the maxillary arch but it would not be beneficial esthetically and would increase the moment perpendicular to the tooth long axis as well as increase the risk of bone dehiscence.

Combretastatin A4 phosphate encapsulated in hyaluronic acid nanoparticles is highly cytotoxic to oral squamous cell carcinoma.

Introduction: To investigate the toxicity of combretastatin A4 phosphate (CA4P) hyaluronic acid (HA) gel nanoparticles (HA-CA4P-NPs) in OSCC (oral squamous cell carcinoma).

Methods: Toxicity was investigated using fluorescence microscopy, MTT assay, flow cytometry, and OSCC xenograft mouse models.

Results: Compared with CA4P, HA-CA4P-NPs generated nearly 10 times more fluorescence in OSCC cells.

Intrapuparial stage aging and PMI estimation based on the developmental transcriptomes of forensically important (Diptera: Calliphoridae) gene expression.

Background: The expression profiles of differentially expressed genes (DEGs) during pupal development have been demonstrated to be vital in age estimation of forensic entomological study. Here, using forensically important (Diptera: Calliphoridae), we aimed to explore the potential of intrapuparial stage aging and postmortem interval (PMI) estimation based on characterization of successive developmental transcriptomes and gene expression patterns.

Methods: We collected pupae at 11 successive intrapuparial stages at 20 °C and used the RNA-seq technique to build the transcriptome profiles of their intrapuparial stages.

High-Efficiency Solar Transformation of Sugars via a Heterogenous Gallium(III) Catalyst.

Extremely limited research exploring the photocatalytic potential of main group metals, such as aluminum, gallium, and tin, has been undertaken due to their weak light harvesting properties. This study reports the efficient transformation of sugars to 5-hydroxymethylfurfural (HMF) with high yield employing an original heterogeneous photocatalyst comprising a gallium(III) complex immobilized on an alumina support. Under visible light irradiation, the reaction rate of HMF formation is ~143 times higher than the equivalent thermal reaction performed in the absence of light.

The clinical and economic burdens of metabolic dysfunction-associated steatohepatitis.

Aims: This study aimed to assess and compare the health care resource utilization (HCRU) and medical cost of metabolic dysfunction-associated steatohepatitis (MASH) by disease severity based on Fibrosis-4 Index (FIB-4) score among US adults in a real-world setting.

Materials And Methods: This observational cohort study used claims data from the Healthcare Integrated Research Database (HIRD) to compare all-cause, cardiovascular (CV)-related, and liver-related HCRU, including hospitalization, and medical costs stratified by FIB-4 score among patients with MASH (identified by International Classification of Diseases, Tenth Revision, Clinical Modification [ICD-10-CM] code K75.81).

Fully Optical Control of Polarization Current Direction in a Cyanide-Bridged Trinuclear Complex.

As a remote and non-contact stimulus, light offers the potential for manipulating the polarization of ferroelectric materials without physical contact. However, in current research, the non-contact write-read (erase) process lacks direct observation through the stable current as output signal. To address this limitation, we investigated the photoinduced polarization switching capabilities of the cyanide-bridged compound [FeCo] using visible light, leading to the achievement of rewritable polarization.

Myricetin ameliorates the severity of pancreatitis in mice by regulating cathepsin B activity and inflammatory cytokine production.

Cathepsin B (CTSB) and inflammatory cytokines are critical in initiating and developing pancreatitis. Calcineurin, a central calcium (Ca)-responsive signaling molecule, mediates acinar cell death and inflammatory responses leading to pancreatitis. However, the detailed mechanisms for regulating CTSB activity and inflammatory cytokine production are unknown.