Tβ4-exosome-loaded hemostatic and antibacterial hydrogel to improve vascular regeneration and modulate macrophage polarization for diabetic wound treatment.

Diabetic wounds often exhibit delayed healing due to compromised vascular function and intensified inflammation. In this study, we overexpressed Thymosin β4 (Tβ4) in Adipose-Derived Stem Cells (ADSCs) to produce Exosomes (Exos) rich in Tβ4. We then utilized a dual photopolymerizable hydrogel composed of Hyaluronic Acid Methacryloyl (HAMA) and Poly-L-lysine Methacryloyl (PLMA) for the sustained release of Tβ4-Exos on diabetic wounds.

An I/amine synergistic catalysis enables 2,2'-bipyridine synthesis from oxime esters and enals.

A synergistic I/secondary amine catalysis has been developed for the modular assembly of 2,2'-bipyridines, employing oxime esters and enals as readily available starting materials. This method demonstrates a good substrate scope and functional group tolerance and can easily afford a series of structurally new 2,2'-bipyridines in moderate to good yields.

An ultra-compact piezoelectric motor with self-satisfied symmetry for enhanced performance.

The symmetry and compactness of the structure has a considerable impact on the properties of piezoelectric motors, including step size, threshold voltage, and effective length. This is particularly evident in motors driven by the inertia principle. Asymmetric and eccentric designs have been observed to result in greater deflections and wobbling during operation, which in turn leads to additional energy loss derived from the energy generated by piezoelectric deformation and further impedes enhancements in overall compactness.

Garcinol promotes wound healing in diabetic mice by regulating inflammation and NLRP3 inflammasome-mediated pyroptosis via the PI3K/Akt/NF-κB pathway.

Diabetic wounds, characterized by chronic inflammation and impaired angiogenesis, often lead to severe complications such as persistent infections and an elevated risk of amputation, significantly affecting a patient's quality of life. Garcinol, a polyisoprenylated benzophenone derived from the rind of Garcinia indica, exhibits potent anti-inflammatory, angiogenic, and antioxidant effects in various disease models. However, its potential to enhance diabetic wound healing remains unclear.

Contact Printing Based on Meniscus Vibration.

Utilizing the residual droplet produced from liquid bridge breakup for microdroplet deposition serves as an important supplementary method to conventional printing techniques. However, this approach typically relies on mechanical motion to form and break the liquid bridge between the liquid donor and acceptor surfaces, resulting in a relatively complex process and low printing efficiency (typically limited to several Hertz). Here, we propose a novel contact printing method based on the meniscus vibration (MVCP).

Tailoring the Catalytic Activity of Metal Catalysts by Laser Irradiation.

In recent years, the rapid advancements in laser technology have garnered considerable interest as an efficient method for synthesizing electrocatalytic nanomaterials. This review delves into the progress made in laser-induced nanomaterials for electrocatalysis, providing a comprehensive overview of the synthesis strategies and catalytic mechanisms involved in defect engineering, morphology tuning, and heterostructure formation. The review highlights the various laser-induced synthesis techniques in producing nanomaterials with enhanced electrocatalytic properties.

A Node Generation and Refinement Algorithm in Meshless RPIM for Electromagnetic Analysis of Sensors.

In sensor design, electromagnetic field numerical simulation techniques are widely used to investigate the working principles of sensors. These analyses help designers understand how sensors detect and respond to external signals during operation. One popular method for electromagnetic field computation is the meshless radial point interpolation method (RPIM), where the number and distribution of nodes are critical to ensuring both accuracy and efficiency.

Axin formation inhibitor 1 aggravates hepatic ischemia‒reperfusion injury by promoting the ubiquitination and degradation of PPARβ.

Hepatic ischemia‒reperfusion injury (HIRI) is a common pathological phenomenon after hepatectomy and liver transplantation. Here, we aim to explore the role of Axin formation inhibitor 1 (Axin1) in HIRI. In this work, we find that the expression of Axin1 is upregulated after HIRI.

Augmentation of exopolysaccharide synthesis and its influence on biofunctional properties of polysaccharide in Sanghuangporus vaninii via targeted overexpression of phosphoglucomutase.

Phosphoglucomutase (PGM) is considered an essential catalyst in polysaccharide biosynthesis, plays a pivotal role in the early stage of carbon metabolism and the synthesis of nucleotide sugars. Polysaccharides are important active components of Sanghuangporus vaninii. Based on the transcriptomic data, the successful cloning and re-annotation of the putative 1353 - bp PGM took place, which encodes a protein of 49.

Multifunctional moisture-driven energy generator for intergation application and thermal-management.

The moisture-driven energy generator (MEG) represents an attractive clean energy strategy in hydropower and photovoltaic technologies. However, despite its potential, MEG still faces challenges in practical applications due to the limitations of single-mode power generation and insufficient output performance. An evaporation-driven dual-layer hydrogel MEG has been developed, which efficiently and stably harvests energy through the synergistic effect between water molecule evaporation and the ion concentration gradient.

Physiological and molecular responses of tropical Seagrass Enhalus acoroides exposed to simultaneous high temperature and hypoxia stress.

High temperature and hypoxia pose significant threats to coastal ecosystems, often co-occurring and intensifying damage to seagrass meadows. While the independent effects of these stresses have been extensively documented, their combined impact on seagrasses remains underexplored. This study investigates the effects of high temperature and hypoxia on Enhalus acoroides, a dominant tropical seagrass.

International digital trade and synergetic control of pollution and carbon emissions: Theory and evidence based on a nonlinear framework.

Amid the urgent global demand for emission reduction and climate change mitigation, the potential of digital trade (DTR) to synergetic control of pollution and carbon emissions (SCPCE) merits in-depth exploration. The study uses panel data from 93 countries between 2009 and 2021 and a nonlinear model to empirically analyze the impact of DTR on SCPCE. The results reveal a U-shaped relationship between DTR and SCPCE, indicating an initial suppressive effect followed by a subsequent positive impact.

Advances in Synthetic Lethality in Potential Oncology Therapeutic Approaches.

Synthetic lethality represents a novel paradigm in molecular targeted cancer therapy. In synthetic lethality, perturbation of one gene alone does not hinder cell viability, yet simultaneous perturbation of both genes results in a loss of cellular viability. The presence of gene mutations in cancer cells, as opposed to normal cells, provides an opportunity for targeted therapies that mimic the effects of the second genetic mutation, enabling selective eradication of cancer cells.

Multi-step functionalization of hydrogels through mechano- and photo-responsive linkages.

Patterning soft materials with cell adhesion motifs can be used to emulate the structures found in natural tissues. While patterning in tissue is driven by cellular assembly, patterning soft materials in the laboratory most often involves light-mediated chemical reactions to spatially control the presentation of cell binding sites. Here we present hydrogels that are formed with two responsive crosslinkers-an anthracene-maleimide adduct and a disulfide linkage-thereby allowing simultaneous or sequential patterning using force and UV light.

A comprehensive DFT/TDDFT investigation into the influence of electron acceptors on the photophysical properties of ullazine-based D-π-A-π-A photosensitizers.

The type of electron acceptor group has a significant effect on the photovoltaic properties of solar cell sensitizers. In this study, on the basis of previous studies of the π1- and π2-linked groups of D-π1-A1-π2-A2-type sensitizers, the photoelectric properties of Ullazine-Based photosensitizing dyes were further optimized by adjusting the electron-absorbing groups at the A1 and A2 positions. DFT and TDDFT calculations revealed that substituting the A1 position with a BTD moiety led to a substantial increase in the light absorption capacity of the dye.

GRINA alleviates hepatic ischemia‒reperfusion injury-induced apoptosis and ER-phagy by enhancing HRD1-mediated ATF6 ubiquitination.

Background & Aims: Hepatic ischemia‒reperfusion injury (HIRI) is a critical complication of liver surgery and transplantation that contributes significantly to severe organ failure. GRINA, a calcium-regulating endoplasmic reticulum (ER) protein, plays an essential role in controlling the unfolded protein response; however, its role in HIRI remains unclear. The aim of this study was to investigate the function of GRINA in HIRI and explore its potential as a therapeutic target.

Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023.

Angucyclines/angucyclinones, a class of polyketides with diverse chemical structures, display various bioactivities including antibacterial or antifungal, anticancer, anti-neuroinflammatory, and anti-α-glucosidase activities. Marine and terrestrial microorganisms have made significant contributions to the discovery of bioactive angucyclines/angucyclinones. This review covers 283 bioactive angucyclines/angucyclinones discovered from 1965 to 2023, and the emphasis is on the biological origins, chemical structures, and biological activities of these interesting natural products.

Cross-species single-cell transcriptomics reveals neuronal similarities and heterogeneity in amniote pallium.

The amniote pallium, a vital component of the forebrain, exhibits considerable evolutionary divergence across species and mediates diverse functions, including sensory processing, memory formation, and learning. However, the relationships among pallial subregions in different species remain poorly characterized, particularly regarding the identification of homologous neurons and their transcriptional signatures. In this study, we utilized single-nucleus RNA sequencing to examine over 130 000 nuclei from the macaque ( ) neocortex, complemented by datasets from humans ( ), mice ( ), zebra finches ( ), turtles ( ), and lizards ( s), enabling comprehensive cross-species comparison.

Allylic C-H oxygenation of unactivated internal olefins by the Cu/azodiformate catalyst system.

Allylic ethers and alcohols are essential structural motifs commonly present in natural products and pharmaceuticals. Direct allylic C-H oxygenation of internal alkenes is one of the most direct methods, bypassing the necessity for an allylic leaving group that is needed in the traditional Tsuji-Trost reaction. Herein, we develop an efficient and practical method for synthesizing (E)-allyl ethers from readily available internal alkenes and alcohols or phenols via selective allylic C-H oxidation.

Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls.

Background: Fibromyalgia is a chronic condition marked by widespread pain and various accompanying symptoms. Compared to healthy individuals and other rheumatic disease patients, it leads to more severe symptoms and a lower quality of life. Whether fibromyalgia patients in a mild activity or remission stage still experience core symptoms remains unclear.

A CD26 tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification.

Inadequate tendon healing and heterotopic bone formation result in substantial pain and disability, yet the specific cells responsible for tendon healing remain uncertain. Here we identify a CD26 tendon stem/progenitor cells residing in peritendon, which constitutes a primitive stem cell population with self-renewal and multipotent differentiation potentials. CD26 tendon stem/progenitor cells migrate into the tendon midsubstance and differentiation into tenocytes during tendon healing, while ablation of these cells led to insufficient tendon healing.

Understanding the relationship between silicone implants, tumor antigens, and breast cancer risk: An immunological study in rats.

This study aimed to investigate the effects of silicone implants on the incidence of breast cancer in rats, as well as their impact on immune surveillance mechanisms. Female SD rats were divided into three groups: a Placebo Surgery Group (PSG), a Thoracic Implant Group (TIG), and a Back Implant Group (BIG). Following the corresponding surgical procedures, we measured Secretoglobin Family 2A, Member 2(SCGB2A2) and Mucin-1 (MUC1) antigen levels using ELISA, and statistical analyses were conducted to evaluate immune responses.

In Situ Balanced Synthesis of High-Activity Low-Spin Iron Cathode Prussian Blue for Enhanced Sodium-Ion Storage.

The growing market for sodium-ion batteries has stimulated interest in research on Prussian blue-type cathode materials. Iron hexacyanoferrate (FeHCF) is considered a desirable Prussian blue-type cathode, but the incomplete electrochemical property of its low-spin iron sites hinders its further practical application. In this paper, carboxymethyl cellulose is demonstrated to have an appropriate binding energy through DFT calculations, synthesize Prussian blue in situ, balance Fe and water in FeHCF, and introduce Fe vacancies to activate low-spin Fe sites.

Improving the bioactivity and mechanical properties of poly(ethylene glycol)-based hydrogels through a supramolecular support network.

Most synthetic hydrogels are formed through radical polymerization to yield a homogenous covalent meshwork. In contrast, natural hydrogels form through mechanisms involving both covalent assembly and supramolecular interactions. In this communication, we expand the capabilities of covalent poly(ethylene glycol) (PEG) networks through co-assembly of supramolecular peptide nanofibers.