Perioperative esketamine combined with butorphanol versus butorphanol alone for pain management following video-assisted lobectomy: a randomized controlled trial.

Background: The analgesic efficacy of esketamine combined with butorphanol in thoracoscopic surgery remains unclear.

Aim: This study explored the effects of perioperative esketamine combined with butorphanol versus butorphanol alone on acute and chronic postoperative pain in patients who underwent video-assisted lobectomy.

Method: A total of 181 patients were enrolled, with 90 in the esketamine-butorphanol group (Group BK) receiving intraoperative esketamine infusion and postoperative patient-controlled intravenous analgesia (PCIA) (esketamine 1.

Understanding stakeholder responses to the electronic cigarette flavor ban in China: A news media analysis.

Objectives: Electronic cigarettes (e-cigarettes) have been attracting users around the world due in part to appealing flavors. Many countries and regions have now taken action to limit the sales of flavored e-cigarettes. In 2022, China implemented a flavor ban on e-cigarettes, prohibiting all but tobacco-flavor.

Biotransformation analysis of daidzin in vitro based on fecal bacteria and probiotics.

Daidzin, as one of isoflavone glycosides, has been reported to have multiple activities with few absorbed into body. However, the metabolic behavior of daidzin by intestinal flora has not been researched, that this defect severely constrains its applications. In this study, daidzin and its metabolites were qualitatively and quantitatively analyzed by HPLC and ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) in the fermentation system for daidzin and fecal bacteria.

Dynamic analysis of FN-HR neural network coupled of bistable memristor and encryption application based on Fibonacci Q-Matrix.

In this paper, a cosine hyperbolic memristor model is proposed with bistable asymmetric hysteresis loops. A neural network of coupled hyperbolic memristor is constructed by using the Fitzhugh-Nagumo model and the Hindmarsh-Rose model. The coupled neural network with a large number of equilibrium points is obtained by numerical analysis.

Hierarchical Polyimide Nonwoven Fabric with Ultralow-Reflectivity Electromagnetic Interference Shielding and High-Temperature Resistant Infrared Stealth Performance.

Designing and fabricating a compatible low-reflectivity electromagnetic interference (EMI) shielding/high-temperature resistant infrared stealth material possesses a critical significance in the field of military. Hence, a hierarchical polyimide (PI) nonwoven fabric is fabricated by alkali treatment, in-situ growth of magnetic particles and "self-activated" electroless Ag plating process. Especially, the hierarchical impedance matching can be constructed by systematically assembling FeO/Ag-loaded PI nonwoven fabric (PFA) and pure Ag-coated PI nonwoven fabric (PA), endowing it with an ultralow-reflectivity EMI shielding performance.

Isolation, characterization, and whole genome sequencing analysis of Aeromonas veronii from Channa argus in China.

Aeromonas veronii has emerged as a significant pathogen that impacts both fish and mammals. Recently, an infectious disease characterized by multiple ulcers on the body surface with a high mortality rate occurred in Channa argus cultured in Jiangsu Province, China. A Gram-negative bacterial strain (Aer12) was isolated from the body surface of the diseased fish and identified as A.

Inclusive leadership, self-efficacy, organization-based self-esteem, and intensive care nurses' job performance: A cross-sectional study using structural equation modeling.

Background: The job performance of intensive care nurses is critical to the treatment and recovery of critically ill patients. Inclusive leadership, self-efficacy and organization-based self-esteem (OBSE) are important psychosocial factors affecting job performance. However, few studies have explored the relationships among these factors in critical care nurses.

Classification of distinct tendinopathy subtypes for precision therapeutics.

Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. Hence, this study attempted a classification of 126 diseased tendons into three distinct subtypes with opposite pathogenic mechanisms based on transcriptomic and clinical features.

Ultrasensitive optical electric field sensor with temperature compensation for point-wise and quasi-distributed sensing.

A point-wise and quasi-distributed optical sensing technique with the Vernier effect is proposed and achieved by multiplexing Fabry-Perot interferometers (FPIs). The FPIs are fabricated by LiNbO (LN) crystals of varying lengths to enable simultaneous measurement of electric field (E-field) and temperature. Compared to the traditional bulk-type optical E-field sensors, this innovative sensor enables E-field measurement without being limited by half-wave voltage and effectively avoids the influence of natural birefringence.

Comprehensive pan-cancer analysis reveals ENC1 as a promising prognostic biomarker for tumor microenvironment and therapeutic responses.

Accumulating research showed that ENC1 plays a critical role in maintaining the physiological functions. However, little is known about its role in predicting prognosis and immunotherapy response across cancers. In our results, compared to normal tissues, most cancer tissues exhibit increased ENC1 expression.

The downstream purification of bispecific antibodies.

Bispecific antibodies, a class of therapeutic antibodies, can simultaneously bind to two distinct targets. Compared with monospecific antibodies, bispecific antibodies offer advantages, including superior efficacy and reduced side effects. However, because of their structural complexity, the purification of bispecific antibodies is highly challenging.

Parameter estimation from single patient, single time-point sequencing data of recurrent tumors.

In this study, we develop consistent estimators for key parameters that govern the dynamics of tumor cell populations when subjected to pharmacological treatments. While these treatments often lead to an initial reduction in the abundance of drug-sensitive cells, a population of drug-resistant cells frequently emerges over time, resulting in cancer recurrence. Samples from recurrent tumors present as an invaluable data source that can offer crucial insights into the ability of cancer cells to adapt and withstand treatment interventions.

High-performance adsorption of methylene blue using novel bio-adsorbent based on sargassum fusiforme.

Large specific surface area obtained by pyrolyzed biomass is considered as a vital factor in improving the dye adsorption performance. However, pyrolysis would cause the inevitable destruction of the surface functional groups of biomass. Herein, a biomass adsorbent based on sargassum fusiforme without pyrolysis was employed for the removal of methylene blue (MB).

Microbiota-derived tryptophan metabolism and AMPK/mTOR pathway mediate antidepressant-like effect of Shugan Hewei Decoction.

Introduction: Depression is a common psychological disorder, accompanied by a disturbance of the gut microbiota and its metabolites. Recently, microbiota-derived tryptophan metabolism and AMPK/mTOR pathway were found to be strongly linked to the development of depression. Shugan Hewei Decoction (SHD) is a classical anti-depression traditional Chinese medicine formula.

Molecular Photoswitching Unlocks Glucose Oxidase for Synergistically Reinforcing Fenton Reactions for Antitumor Chemodynamic Therapy.

We have developed a new type of nanoparticles with potent antitumor activity photoactivatable via the combination of molecular photoswitching of spiropyran (SP) and enzymatic reaction of glucose oxidase (GOx). As two key processes involved therein, Fe(III)-to-Fe(II) photoreduction in Fe(III) metal-organic frameworks (MOFs) brings about the release of free Fe/Fe while the photoswitching of SP to merocyanine (MC) unlocks the enzymatic activity of GOx that was pre-passivated by SP. The release of free Fe boosts its hydrolysis and therefore enables the acidification of microenvironment, which is further reinforced by one of the products of the GOx-mediated glucose oxidation reaction, gluconic acid (GlcA).

State Observer Synchronization of Three-dimensional Chaotic Oscillatory Systems Based on DNA Strand Displacement.

Currently, DNA strand displacement (DSD) as the theoretical basis of DNA chemical reaction networks (CRNs) has promoted the development of chaotic synchronization technique. This paper introduces the synchronization technology of two isomorphic three-dimensional chaotic systems based on DNA strand displacement under state observer. By studying the theoretical knowledge of DNA molecules, multiple DSD reactions are used to construct three-dimensional chaotic system.

Identification of SDG gene family members and exploration of flowering related genes in different cultivars of chrysanthemums and their wild ancestors.

The SET domain genes (SDGs) are significant contributors to various aspects of plant growth and development, mainly includes flowering, pollen development, root growth, regulation of the biological clock and branching patterns. To clarify the biological functions of the chrysanthemum SDG family, the SDG family members of four chrysanthemum cultivars and three related wild species were identified; their physical and chemical properties, protein domains and conserved motifs were predicted and analyzed. The results showed that 59, 67, 67, 102, 106, 114, and 123 SDGs were identified from Chrysanthemum nankingense, Chrysanthemum lavandulifolium, Chrysanthemum seticuspe, Chrysanthemum × morifolium cv.

Plasma Proteomics to Identify Drug Targets and Potential Drugs for Retinal Artery Occlusion: An Integrated Analysis in the UK Biobank.

Retinal artery occlusion (RAO), which is positively correlated with acute ischemic stroke (IS) and results in severe visual impairment, lacks effective intervention drugs. This study aims to perform integrated analysis using UK Biobank plasma proteome data of RAO and IS to identify potential targets and preventive drugs. A total of 7191 participants (22 RAO patients, 1457 IS patients, 8 individuals with both RAO and IS, and 5704 healthy age-gender-matched controls) were included in this study.

Genome-Wide Association Studies of Growth Trait Heterosis in Crossbred Meat Rabbits.

The application of heterosis can not only effectively improve the disease resistance and meat quality of livestock, but also significantly enhance the reproduction and growth of livestock and poultry. We conducted genome-wide association studies using data from F2 crossbred meat rabbits to screen out candidate genes with significant dominant effects associated with economic trait variation. High-throughput sequencing technology was used to obtain SNPs covering the whole genome to evaluate the homozygosity of the population genome, and analyze the number, length, frequency, and distribution of ROHs in the population.

Nondestructive flash cathode recycling.

Effective recycling of end-of-life Li-ion batteries (LIBs) is essential due to continuous accumulation of battery waste and gradual depletion of battery metal resources. The present closed-loop solutions include destructive conversion to metal compounds, by destroying the entire three-dimensional morphology of the cathode through continuous thermal treatment or harsh wet extraction methods, and direct regeneration by lithium replenishment. Here, we report a solvent- and water-free flash Joule heating (FJH) method combined with magnetic separation to restore fresh cathodes from waste cathodes, followed by solid-state relithiation.

Saliva, Plasma, and Multifluid Metabolomic Signatures of Periodontal Disease, Type 2 Diabetes Progression, and Markers of Glycemia and Dyslipidemia Among Puerto Rican Adults With Overweight and Obesity.

Background: Evidence from cohort studies indicates a bidirectional relationship between periodontal disease and type 2 diabetes (T2D), but the underlying mechanisms remain unknown. In this study, we aimed to (1) identify saliva, plasma, and multifluid metabolomic signatures associated with periodontal disease and (2) determine if these signatures predict T2D progression and cardiometabolic biomarkers at year 3.

Methods And Results: We included participants from the SOALS (San Juan Overweight Adult Longitudinal Study) (n=911).