Publications by authors named "Zi-yu Xu"

Background: This is the first study to evaluate the efficacy of short-term Spinal Cord Stimulation (st-SCS) versus debridement for treating Diabetic Foot Ulcers (DFU).

Methods: We retrospectively analyzed records from DFU patients treated at our hospital. Patients were divided into two groups: 62 received st-SCS with debridement (SCS group), and 43 received only debridement (debridement group).

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The century-old inverted Keggin ion has been revisited in an effort to unleash its potential in the structural engineering and functional development of polyoxomolybdates (POMos). Over the past hundred years, attempts to program the metal-oxo scaffold of inverted Keggins have been conducted continually but without any success. In this work, a structurally inert, inverted Keggin-type POMo could finally be altered by means of a binary heterogroup-templated approach, resulting in the successful isolation of two lacunary species.

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Article Synopsis
  • The study investigated the association between alkaline phosphatase (ALP) levels and overall survival in 202 newly diagnosed multiple myeloma (MM) patients at Beijing Chaoyang Hospital from 2012 to 2016.
  • Patients were categorized into three groups based on ALP levels, and various health indicators, including liver function and bone disease severity, showed significant differences across these groups.
  • The results indicated that median survival times varied by ALP group, with Group 2 showing the highest 3-year survival rate, while factors like age and disease staging were identified as independent survival influencers.
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Background: To analyze the learning curve of novices in mastering short-term Spinal cord stimulation (st-SCS) for diabetic foot, evaluating the efficacy, safety, and difficulty of this technique.

Methods: A retrospective review of diabetic foot patients treated with st-SCS at our hospital was conducted. All procedures were performed by the same physician and patients were sequentially numbered according to the order of surgery.

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Background: To investigate the prognosis of patients with Multiple Myeloma (MM) after surgery, analyze the risk factors leading to adverse postoperative outcomes, and establish a nomogram.

Methods: Clinical data from 154 patients with MM who underwent surgery at our institution between 2007 and 2019 were retrospectively analyzed. Assessing and comparing patients' pain levels, quality of life, and functional status before and after surgery (P < 0.

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Senescence, an intricate and inevitable biological process, characterized by the gradual loss of homeostasis and declining organ functions. The pathological features of cellular senescence, including cell cycle arrest, metabolic disruptions, and the emergence of senescence-associated secretory phenotypes (SASP), collectively contribute to the intricate and multifaceted nature of senescence. Beyond its classical interaction with p53, murine double minute gene 2 (MDM2), traditionally known as an E3 ubiquitin ligase involved in protein degradation, plays a pivotal role in cellular processes governing senescence.

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Purpose: To investigate the effectiveness and safety of separation surgery for Epidural Spinal Cord Compression (ESCC) graded ≥ 2 in patients with Multiple Myeloma (MM), analyze factors influencing surgical outcomes, and develop a preliminary treatment decision framework for these patients.

Methods: A retrospective analysis was conducted on clinical data from 35 MM patients who underwent separation surgery for ESCC graded ≥ 2 between 2013 and 2018. Patient data, including baseline information, surgical details, complications, and pre-operative as well as one-month post-operative efficacy evaluation indicators were recorded.

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Granular cell tumors are extremely uncommon soft tissue neoplasms that mostly occur in the head and neck regions. Granular cell tumors are generally benign, asymptomatic, and rarely involve the median nerve. Due to the lack of awareness about granular cell tumors, they are easily misdiagnosed and mistreated in primary hospitals.

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Objective: This study aimed to describe the learning curve of surgeons performing tibial cortex transverse transport (TTT) and explore its safety and effectiveness during the initial stages of surgeon's learning.

Methods: The clinical data of patients with diabetic foot ulcers classified as Wagner grade ≥ 2, who underwent TTT at our hospital from January 2020 to July 2021, were included in this retrospective analysis. The same physician performed all procedures.

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Purpose: Methamphetamine use may cause severe neurotoxicity and cognitive impairment, leading to addiction, overdose, and high rates of relapse. However, few studies have systematically focused on functional impairments detected by neuroimaging in methamphetamine abstainers (MAs) during short-term abstinence. This study aimed to investigate effective connectivity, resting-state networks, and internetwork functional connectivity in MA brains to improve clinical treatment.

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Background: The neutrophil-lymphocyte ratio (NLR) is often used to predict a poor prognosis in patients with tumors. This study investigated the preoperative peripheral blood NLR in predicting postoperative survival (POS) in patients with multiple myeloma bone disease (MMBD).

Aim: To evaluate whether NLR can be used to predict the prognosis of MMBD patients after surgery.

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Background: Multiple myeloma is an incurable malignant plasma cell disorder that represents the most common primary malignant bone tumor. It commonly involves bone metastasis in multiple vertebral bodies, and the Spinal Instability Neoplastic Score scoring system may not be fully applicable to multiple myeloma (MM) patients.

Aim: To evaluate the spinal stability of patients with MM spinal involvement to guide their clinical treatment.

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Article Synopsis
  • The study aimed to compare the effectiveness of tension-band wiring (TBW) and the cable pin system (CPS) in treating transverse patella fractures in 73 patients from an academic trauma center.
  • Results showed that the CPS group had a significantly shorter healing time and fewer complications compared to the TBW group, with all fractures healing successfully.
  • The CPS also resulted in a better functional outcome as indicated by higher scores on the Hospital for Special Surgery assessment, showcasing it as a preferable treatment option.
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Synopsis of recent research by authors named "Zi-yu Xu"

  • - Zi-Yu Xu's recent research encompasses advancements in the fields of structural engineering and cancer prognosis, particularly focusing on polyoxomolybdates and multiple myeloma, revealing significant correlations between biochemical markers and patient outcomes.
  • - Notable publications include the successful modification of inverted Keggin ions for structural applications, and analyses linking alkaline phosphatase levels and neutrophil-lymphocyte ratios to survival rates in multiple myeloma patients.
  • - The author has also explored practical applications in neurosurgery, investigating the learning curves for spinal cord stimulation techniques and surgical interventions for spinal cord compression, indicating significant implications for training and surgical efficiency.

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