[Clinical characteristics and prognosis in 12 children with SARS-CoV-2 Omicron variant infection-associated acute necrotizing encephalopathy].

Objectives: To study the clinical characteristics and prognosis of SARS-CoV-2 Omicron variant infection-associated acute necrotizing encephalopathy (ANE) in children

Methods: A retrospective analysis was conducted on the medical data of 12 children with SARS-CoV-2 Omicron variant infection-associated ANE who were admitted to the Pediatric Intensive Care Unit, Qingdao Women and Children's Hospital from December 18 to 29, 2022. The children were divided into two groups based on outcomes: death group (7 cases) and survival group (5 cases). The clinical manifestations and auxiliary examination results were compared between the two groups.

Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection.

Background: Recurrent respiratory tract infection (RRTI) is a disease occurred frequently in preschool children.

Methods: A total of 120 RRTI children were randomly divided into active group, remission group, intervention group and control group, meanwhile 30 healthy children were selected as the healthy group. Children in the intervention group were given oral Bifidobaeterium tetravaccine tablets (Live) for 2 months, while the control group received routine treatment.

[Clinical features of children with Epstein-Barr virus-related acute liver failure: an analysis of four cases].

A retrospective analysis was performed for the clinical data of four children with Epstein-Barr virus (EBV)-related acute liver failure. There were two boys and two girls with a median age of 10 months (range 8.5-44 months).

[Association between S100B gene polymorphisms and hand, foot and mouth disease caused by enterovirus 71 infection].

Objective: To investigate the association between rs9722 polymorphisms in the S100B gene and hand, foot and mouth disease (HFMD) caused by enterovirus 71.

Methods: A total of 124 HFMD children with enterovirus 71 infection were enrolled as subjects, and 56 healthy children were enrolled as control group. The rs9722 polymorphisms in the S100B gene were detected for both groups, and the serum level of S100B protein was measured for 74 HFMD children.

[Effect of milkvetch injection on immune function of children with tetralogy of Fallot after radical operation].

Objective: To evaluate the effect of milkvetch injection (MI) on immune function of children with tetralogy of Fallot (TOF) after radical operation.

Methods: Forty-children with TOF were divided into two groups, the 20 in the control group treated with conventional treatment alone and the 20 in the treated group treated with conventional treatment plus 15 ml of MI every 12 hrs for 14 days. Changes of immunoglobulin, complements, lymphocyte phenotypes and cytokines were observed.

[Effect of Milkvetch Injection on cardiac function and hemodynamics in children with tetralogy of Fallot after radical operation].

Objective: To evaluate the effect of Milkvetch Injection (MI) on cardiac function and hemodynamics in children with tetralogy of Fallot after radical operation.

Methods: Thirty-two children with tetralogy of Fallot were divided into two groups, the 20 patients in the control group treated with conventional treatment and the 12 patients in the treated group treated with 15 ml of MI every 12 hrs for 7 days. The cardiac function and hemodynamic parameters were determined by echocardiography and thermodilution catheter inserted in pulmonary artery.

Effects of astragaloside IV on myocardial calcium transport and cardiac function in ischemic rats.

Aim: To explore the effects of astragaloside IV (XGA) on myocardial calcium transport and cardiac function in ischemic rats.

Methods: Eighty-four Wistar rats were divided into three groups: control group (n=12); ischemic group (n=12) was given isoprenaline injection sc at a dose of 30 mg/kg; and XGA group (n=60) was given XGA after isoprenaline administration. The changes of the parameters of hemodynamics, cardiac function, and intra- and extracellular calcium concentration of the myocardial cells were determined.