DUSP19 regulates IL-1β-induced apoptosis and MMPs expression in rat chondrocytes through JAK2/STAT3 signaling pathway.

Osteoarthritis (OA) is a disease with degeneration of articular cartilage and its development and progression is characterized by chondrocyte apoptosis. To examine whether DUSP19 and inhibitor of the JAK2/STAT3 will influence the response of rat chondrocytes cultured with IL-1β. Dose-response studies were conducted under IL-1β conditions.