Publications by authors named "Zi-Yu Kuang"
The two-component regulatory system CenK-CenR has recently emerged as a regulator of cell envelope and cell division processes in the alpha-proteobacteria. In Sinorhizobium meliloti, CenK-CenR regulates the expression of SrlA, a thioredoxin-domain protein of unknown function. Deletion of srlA causes sensitivity to salt and oxidizing agents on solid growth medium.
View Article and Find Full Text PDFBackground: Gastric cancer (GC) is the fifth most commonly diagnosed malignancy worldwide, with over 1 million new cases per year, and the third leading cause of cancer-related death.
Aim: To determine the optimal perioperative treatment regimen for patients with locally resectable GC.
Methods: A comprehensive literature search was conducted, focusing on phase II/III randomized controlled trials (RCTs) assessing perioperative chemotherapy and chemoradiotherapy in treating locally resectable GC.
Multifaceted role of microRNAs in gastric cancer stem cells: Mechanisms and potential biomarkers.
World J Gastrointest Oncol
February 2024
MicroRNAs (miRNAs) have received much attention in the past decade as potential key epigenomic regulators of tumors and cancer stem cells (CSCs). The abnormal expression of miRNAs is responsible for different phenotypes of gastric cancer stem cells (GCSCs). Some specific miRNAs could be used as promising biomarkers and therapeutic targets for the identification of GCSCs.
View Article and Find Full Text PDFArticle Synopsis
- The study identified a new gene in a nitrogen-fixing bacterial symbiont that is essential for growth in high salt environments and shows increased sensitivity to oxidative stress.
- The gene, named stress resistance locus A (srlA), encodes a protein with a thioredoxin fold, and its deletion led to interesting genetic revertants that altered the bacterial response to stress.
- Additionally, the research revealed that the srlA promoter is autoregulated and requires specific sequence elements for high activity, while a response regulator protein (CenR) likely acts as a Class II activator influencing the transcription of srlA under stress conditions.
[Network Meta-analysis of traditional Chinese medicine in treating drug-induced liver injury].
Zhongguo Zhong Yao Za Zhi
October 2020
To systematically evaluate the efficacy and safety of Chinese medicine in the treatment of drug-induced liver injury(DILI). By searching the randomized controlled trials(RCTs) of the Chinese medicine published in CNKI, WanFang, VIP, PubMed, Web of Science, in a time limit from database establishment to May 1, 2020. The bias risk assessment and Meta-analysis were then conducted for the included studies.
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