A novel integrated testing strategy (ITS) for evaluating acute fish toxicity with new approach methodologies (NAMs).

Acute fish toxicity (AFT) tests are performed in aquatic risk assessments of chemical compounds globally. However, the specific endpoint of in vivo AFT is based on the lethal concentration 50 (LC), which is a serious challenge in terms of animal welfare. To support the 3Rs principle of replacing, reducing, and refining use of animals, integrated testing strategies (ITS) have recently been developed for environmental risk assessment.

Realization of Forest Internet of Things Using Wireless Network Communication Technology of Low-Power Wide-Area Network.

This work implements an intelligent forest monitoring system using the Internet of things (IoT) with the wireless network communication technology of a low-power wide-area network (LPWAN), a long range (LoRa), and a narrow-band Internet of things (NB-IoT). A solar micro-weather station with LoRa-based sensors and communications was built to monitor the forest status and information such as the light intensity, air pressure, ultraviolet intensity, CO, etc. Moreover, a multi-hop algorithm for the LoRa-based sensors and communications is proposed to solve the problem of long-distance communication without 3G/4G.

High-harmonic generation in polycrystalline CdTe nano-films via macroscopic investigations.

Bright high harmonics generation (HHG) in CMOS-compatible nano-films can provide new opportunities for integrated coherent ultra-violet sources and attosecond photonic devices. Up to now, most HHG studies have been limited to single crystals. Polycrystalline materials, which consist of many grains separated by grain boundaries and normally have random crystallographic orientations, have rarely been explored for HHG.

Airborne Avian Influenza Virus in Ambient Air in the Winter Habitats of Migratory Birds.

Outbreaks of avian influenza virus (AIV) have raised public concerns recently. Airborne AIV has been evaluated in live poultry markets and case farms; however, no study has discussed airborne AIV in ambient air in the winter habitats of migratory birds. Therefore, this study aimed to evaluate airborne AIV, specifically H5, H7, and H9, in a critical winter habitat of migratory birds and assess the factors influencing airborne AIV transmission in ambient air to provide novel insights into the epidemiology of avian influenza.

Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae.

Nanotechnology allows for a greater quality of life, but may also cause environmental and organismic harm. Zinc oxide nanoparticles (ZnONPs) are one of the most commonly used metal oxide nanoparticles for commercial and industrial products. Due to its extensive use in various fields, there has already been much concern raised about the environmental health risks of ZnONPs.

Direct generation of relativistic isolated attosecond pulses in transmission from laser-driven plasmas.

Isolated attosecond pulses are useful to perform pump-probe experiments at a high temporal resolution, and provide a new tool for ultrafast metrology. However, it is still a challenging task to generate such pulses of high intensity, even for a few-cycle laser. Through particle-in-cell simulations, we show that it is possible to directly generate a giant isolated attosecond pulse in the transmission direction from relativistic laser-driven plasmas.

The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos.

As the worldwide application of nanomaterials in commercial products increases every year, various nanoparticles from industry might present possible risks to aquatic systems and human health. Presently, there are many unknowns about the toxic effects of nanomaterials, especially because the unique physicochemical properties of nanomaterials affect functional and toxic reactions. In our research, we sought to identify the targets and mechanisms for the deleterious effects of two different sizes (~10 and ~50 nm) of amine-modified silver nanoparticles (AgNPs) in a zebrafish embryo model.

Divergence control of relativistic harmonics by an optically shaped plasma surface.

The unique spatial and temporal properties of relativistic high harmonics generated from a laser-driven plasma surface allow them to be coherently focused to an extremely high intensity reaching the Schwinger limit. The ultimately achievable intensity is limited by the harmonic wavefront distortions during the interactions. Here we demonstrate experimentally that the harmonic divergence can be controlled by an optically shaped plasma surface with a prepulse that has the same spatial and temporal distribution as the main laser pulse.

The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies.

Nanotechnology has rapidly promoted the development of a new generation of industrial and commercial products; however, it has also raised some concerns about human health and safety. To evaluate the toxicity of the great diversity of nanomaterials (NMs) in the traditional manner, a tremendous number of safety assessments and a very large number of animals would be required. For this reason, it is necessary to consider the use of alternative testing strategies or methods that reduce, refine, or replace (3Rs) the use of animals for assessing the toxicity of NMs.

Digital halftoning method with simultaneously optimized perceptual image quality and drive current for multi-tonal electrophoretic displays.

While using digital halftoning to achieve multi-tones in a 1 bit electrophoretic display (EPD), e.g., a three-pigment chromatic EPD, the drive current is significantly increased because of frequently reversed pixel values.

Strong-field nonlinear optical properties of monolayer black phosphorus.

Within the past few years, atomically thin black phosphorus (BP) has been demonstrated as a fascinating new 2D material that is promising for novel nanoelectronic and nanophotonic applications, due to its many unique properties such as a direct and widely tunable bandgap, high carrier mobility and remarkable intrinsic in-plane anisotropy. However, its important extreme nonlinear behavior and the ultrafast dynamics of carriers under strong-field excitation have yet to be revealed. Herein, we report nonperturbative high harmonic generation (HHG) in monolayer BP by first-principles simulations.

Circularly polarized extreme ultraviolet high harmonic generation in graphene.

Circularly polarized extreme ultraviolet (XUV) radiation is highly interesting for investigation of chirality-sensitive light-matter interactions. Recent breakthroughs have enabled the generation of such light sources via high harmonic generation (HHG) from rare gases. There is a growing interest in extending HHG medium from gases to solids, especially to 2D materials, as they hold great promise to develop ultra-compact solid-state photonic devices and provide insights into electronic properties of the materials themselves.

Altered Corneal Nerves in Chinese Thyroid-Associated Ophthalmopathy Patients Observed by In Vivo Confocal Microscopy.

BACKGROUND Thyroid-associated ophthalmopathy (TAO) is a common endocrine autoimmune disease. The present study explored corneal nerve changes in TAO patients. MATERIAL AND METHODS Thirty-eight Chinese TAO patients and 20 healthy individuals were included in the study.

Strain-controlled high harmonic generation with Dirac fermions in silicene.

Two-dimensional (2D) materials with zero band gap exhibit remarkable electronic properties with wide tunability. High harmonic generation (HHG) in such materials offers unique platforms to develop novel optoelectronic devices at the nanoscale, as well as to investigate strong-field and ultrafast nonlinear behaviour of massless Dirac fermions. However, control of HHG by modulating the electronic structures of materials has remained largely unexplored to date.

An Improved Technique for Obtaining Accurate and Precise Morphometric Data on Snakes.

Morphometric measurements are basic but essential data in morphological and ecological research. It is thus beneficial to develop a safe, convenient, multipurpose device/technique to determine body length and physical characteristics of living snakes with high accuracy/precision and low stress, and to enable the probing of snakes and collection of tissue samples. To meet these requirements, we developed an improved technique, which we named the Confining-Box Method (CBM).

Spectral control of high harmonics from relativistic plasmas using bicircular fields.

We introduce two-color counterrotating circularly polarized laser fields as a way to spectrally control high harmonic generation (HHG) from relativistic plasma mirrors. Through particle-in-cell simulations, we show that only a selected group of harmonic orders can appear owing to the symmetry of the laser fields and the related conservation laws. By adjusting the intensity ratio of the two driving field components, we demonstrate the overall HHG efficiency, the relative intensity of allowed neighboring harmonic orders, and that the polarization state of the harmonic source can be tuned.

Isolated attosecond pulse in the water window from many-cycle laser-driven plasma mirrors without pulse engineering.

High-order harmonic generation from relativistic laser-driven plasma mirrors is an attractive route to produce highly energetic attosecond pulses in the extreme ultraviolet to x-ray regime. To achieve an isolated attosecond pulse (IAP) driven by many-cycle intense laser pulses, pulse engineering techniques such as polarization modulation and wavefront rotation, are usually needed. Here we show that it is possible to generate an IAP without pulse engineering.

Isolated elliptically polarized attosecond soft X-ray with high-brilliance using polarization gating of harmonics from relativistic plasmas at oblique incidence.

The production of intense isolated attosecond pulse is a major goal in ultrafast research. Recent advances in high harmonic generation from relativistic plasma mirrors under oblique incidence interactions gave rise to photon-rich attosecond pulses with circular or elliptical polarization. However, to achieve an isolated elliptical attosecond pulse via polarization gating using currently available long driving pulses remains a challenge, because polarization gating of high harmonics from relativistic plasmas is assumed only possible at normal or near-normal incidence.

Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses.

Silver nanoparticles (AgNPs) are widely used in the household, medical and industrial sectors due to their effective bactericidal activities and unique plasmonic properties. Despite the promising advantages, safety concerns have been raised over the usage of AgNPs because they pose potential hazards. However, the mechanistic basis behind AgNPs toxicity, particularly the sublethal effects at the organismal level, has remained unclear.

Prognostic role of systemic immune-inflammation index in solid tumors: a systematic review and meta-analysis.

Background: Inflammation may play an important role in cancer progression, and a higher systemic immune-inflammation index (SII) has been reported to be a poor prognostic marker in several malignancies. However, the results of published studies are inconsistent.

Materials And Methods: A systematic review of databases was conducted to search for publications regarding the association between blood SII and clinical outcome in solid tumors with a date up to February 12, 2017.

Criticality-Enhanced Magnetocaloric Effect in Quantum Spin Chain Material Copper Nitrate.

In this work, a systematic study of Cu(NO)·2.5 HO (copper nitrate hemipentahydrate, CN), an alternating Heisenberg antiferromagnetic chain model material, is performed with multi-technique approach including thermal tensor network (TTN) simulations, first-principles calculations, as well as magnetization measurements. Employing a cutting-edge TTN method developed in the present work, we verify the couplings J = 5.

The clinicopathological significance of miR-149 and PARP-2 in hepatocellular carcinoma and their roles in chemo/radiotherapy.

Hepatocellular carcinomas (HCC) are commonly diagnosed at an advanced stage with unresectable tumors. Although numerous non-surgical approaches have been developed to treat HCC, the prognosis of patients with HCC is still poor. This study investigated the expression of miR-149 and PARP-2 in HCC tumor tissues and their roles in sensitizing chemo/radiotherapy.

Bright high-order harmonic generation with controllable polarization from a relativistic plasma mirror.

Ultrafast extreme ultraviolet (XUV) sources with a controllable polarization state are powerful tools for investigating the structural and electronic as well as the magnetic properties of materials. However, such light sources are still limited to only a few free-electron laser facilities and, very recently, to high-order harmonic generation from noble gases. Here we propose and numerically demonstrate a laser-plasma scheme to generate bright XUV pulses with fully controlled polarization.