Publications by authors named "Zi-Yao Xiao"
Article Synopsis
- Oxidative stress is linked to various neurological disorders, and the study examines the role of Cpg15, a neurotrophic factor, in this context.
- Cpg15 expression decreases under oxidative stress, while its overexpression enhances antioxidant enzyme activity and reduces prooxidative COX2 and malondialdehyde levels.
- The findings suggest that boosting Cpg15 expression may mitigate oxidative stress in neurons by influencing redox enzymes and activating the Nrf2 antioxidant pathway.
Decreased cpg15 augments oxidative stress in sleep deprived mouse brain.
Biochem Biophys Res Commun
February 2020
Sleep deprivation (SD) has detrimental effects on the physiological function of the brain. However, the underlying mechanism remains elusive. In the present study, we investigated the expression of candidate plasticity-related gene 15 (cpg15), a neurotrophic gene, and its potential role in SD using a REM-SD mouse model.
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