Monomeric, Dimeric, and Trimeric Tropane Alkaloids from .

Seven new tropane alkaloids, including five monomeric (-), one dimeric (), and one trimeric () 3α-nortropane ester, along with two known monomeric nortropane alkaloids ( and ), were isolated from the leaves and bark of . Their structures, including the absolute configuration of the enantiomeric pair of (±)-, were elucidated by comprehensive spectroscopic analyses. Alkaloids and showed cytotoxicity toward human pancreatic cancer cell lines (AsPC-1, BxPC3, PANC-1, and SW1990).

Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition.

Natural products possess a significant role in anticancer therapy and many currently-used anticancer drugs are of natural origin. Cerberin (CR), a cardenolide isolated from the fruit kernel of Cerbera odollam, was found to potently inhibit cancer cell growth (GI values < 90 nM), colony formation and migration. Significant G2/M cell cycle arrest preceded time- and dose-dependent apoptosis-induction in human cancer cell lines corroborated by dose-and time-dependent PARP cleavage and caspase 3/7 activation, in addition to reduced Bcl-2 and Mcl-1 expression.