Publications by authors named "Zi-Yan Shi"
Article Synopsis
- The study investigates the role of antinuclear antibodies (ANAs) in the long-term prognosis of Chinese patients with Neuromyelitis optica spectrum disorder (NMOSD), revealing potentially significant correlations.
- Among 525 patients, those with ANA showed higher frequencies of certain antibodies, higher disability scores, and more severe disease attacks compared to those without ANAs.
- The findings suggest that ANA presence might indicate more severe disease activity and disability in NMOSD patients, though there was no significant difference in the annual recurrence rate between the two groups.
Background: Many patients with neurological disorders experience chronic fatigue, but the neural mechanisms involved are unclear.
Objective: Here we investigated whether the brain structural and functional connectivity alterations were involved in fatigue related to neuromyelitis optica spectrum disorder (NMOSD).
Methods: This prospective pilot study used structural and resting-state functional brain magnetic resonance imaging to compare total cortical thickness, cortical surface area, deep gray matter volume and functional connectivity (FC) between 33 patients with NMOSD and 20 healthy controls (HCs).
Variants at the GTF2I repeat domain containing 1 (GTF2IRD1)-GTF2I locus are associated with primary Sjögren's syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Numerous studies have indicated that this susceptibility locus is shared by multiple autoimmune diseases. However, until now there were no studies of the correlation between GTF2IRD1-GTF2I polymorphisms and neuromyelitis optica spectrum disorders (NMOSD).
View Article and Find Full Text PDF[Anxiety and Depression in Patients with Neuromyelitis Optica].
Sichuan Da Xue Xue Bao Yi Xue Ban
November 2017
Objective: To assess anxiety and depression in patients with neuromyelitis optica (NMO).
Methods: Eligible patients with NMO were assessed with Hamilton anxiety rating scale-14 (HARS-14),Hamilton depression rating scale-21 (HDRS-21) and expanded disability status scale (EDSS).
Results: A total of 65 NMO patients [(39.
This study aimed to reveal the clinical course and outcomes of myasthenia gravis (MG) in patients with thymic lymphoid hyperplasia and thymoma undergoing extended thymectomy and to identify the clinical prognostic factors of remission for MG. In total, 73 patients undergoing extended thymectomy were divided into two groups: group A with lymphoid hyperplasia (n=39) and group B with thymoma (n=34). According to the MG Foundation of America (MGFA) post-intervention status, the primary endpoint was a composite measure defined as achievement of complete stable remission (CSR), pharmacologic remission (PR), minimal manifestations (MM) or improvement (IM).
View Article and Find Full Text PDFMuscle damage in patients with neuromyelitis optica spectrum disorder.
Neurol Neuroimmunol Neuroinflamm
November 2017
Objective: Increasing evidence has shown that skeletal muscle damage plays a role in neuromyelitis optica spectrum disorder (NMOSD). The objective of this study was to compare the serum creatine kinase (sCK) levels in NMOSD patients with different clinical statuses.
Methods: In the observational study, levels of sCK were measured during the acute and stable phases for patients with NMOSD and healthy controls (HCs).
[Correlates of Fatigue in Patients with Neuromyelitis Optica].
Sichuan Da Xue Xue Bao Yi Xue Ban
July 2016
Objectives: To determine clinical characteristics associated with fatigue in patients with neuromyelitis optica (NMO).
Methods: A questionnaire survey was conducted in NMO patients, measuring fatigue using the fatigue impact scale (FIS).
Results: A total of 64 NMO patients (mean age: 50.