Publications by authors named "Zi-Yan Peng"
Purpose: This study identified novel variants of the FSIP2 and SPEF2 genes in multiple morphological abnormalities of the sperm flagella (MMAF) patients and to investigate the potential effect of variations on male infertility and assisted reproductive outcomes.
Methods: Whole-exome sequencing was performed in 106 Chinese MMAF patients. The discovered variants were evaluated in silico and confirmed by Sanger sequencing.
Article Synopsis
- Necrozoospermia is a rare condition that makes it hard for men to have healthy sperm, affecting about 3.4% of men in a study of 650 couples.
- The study found that older age and certain factors in sperm quality are linked to necrozoospermia.
- Men with necrozoospermia had lower success rates for fertilization than men without this condition, so it's important for doctors to know about it when helping couples who want to have kids.