Doxazosin Attenuates Development of Testosterone Propionate-induced Prostate Growth by regulating TGF-β/Smad Signaling Pathway, Prostate-specific Antigen Expression and Reversing Epithelial-mesenchymal Transition in Mice and Stroma Cells.

Background: Finasteride and doxazosin are used for the treatment of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Epithelial-mesenchymal transition (EMT) plays an important role in BPH, little is known about the growth inhibition and anti-fibrosis effects of doxazosin on the regulation of EMT and morphology in the prostate.

Objectives: The present study examined the effects of doxazosin on testosterone propionate (TP)-induced prostate growth in vivo and in vitro and its impact on the EMT and TGF-β/Smad signaling pathway.

Capsaicin reduces blood glucose and prevents prostate growth by regulating androgen, RAGE/IGF-1/Akt, TGF-β/Smad signalling pathway and reversing epithelial-mesenchymal transition in streptozotocin-induced diabetic mice.

Type 2 diabetes mellitus (T2DM) is a metabolic disease. Diabetes increases the risk of benign prostatic hyperplasia (BPH). Capsaicin is extracted from chili peppers and possesses many pharmacological properties, including anti-diabetic, pain-relieving, and anti-cancer properties.

EQ-5D-5L Population Norms for China Derived From a National Health Survey.

Objectives: To develop the EQ-5D-5L (5L) population norms for China and to assess the relationship between various factors and 5L data.

Methods: This study used data derived from the Psychology and Behavior Investigation of Chinese Residents, a national sample survey of 21 909 representative participants aged 12 years and above. Participants' health-related quality of life (HRQoL) was measured by the 5L.

Advancing single-cell RNA-seq data analysis through the fusion of multi-layer perceptron and graph neural network.

The advancement of single-cell sequencing technology has smoothed the ability to do biological studies at the cellular level. Nevertheless, single-cell RNA sequencing (scRNA-seq) data presents several obstacles due to the considerable heterogeneity, sparsity and complexity. Although many machine-learning models have been devised to tackle these difficulties, there is still a need to enhance their efficiency and accuracy.

Three new species, and new distributional data, of (Hymenoptera, Chalcididae) from China.

Five species of (Hymenoptera, Chalcididae) from China are reviewed, including three new species, Wang & Li, , Wang & Li, , Wang & Li, (Ashmead) is newly recorded from China and Habu is newly recorded from Heilongjiang, Shanxi, Shandong, Xizang, Guangdong and Yunnan Provinces in China. A key to the Chinese species of the is provided.

Carbon sink calculation model of urban construction land based on building capacity.

The exploitation and utilization of mineral materials during urban construction causes a large amount of carbon emission, but could also contribute to carbon sequestration. In the related literature, carbon sequestration process of building mineral materials has received limited attention and scientific quantification. On the basis of extracting building capacity and identifying building types, we used the technology of remote sensing image shadow height inversion to quantify mineral material consumption and carbon content parameters.

Consolidation chwemotherapy after concurrent chemoradiotherapy vs. chemoradiotherapy alone for locally advanced unresectable stage III non-small-cell lung cancer: A meta-analysis.

Concurrent chemoradiotherapy (CCRT) has been considered to be the standard of care for locally advanced unresectable stage III non-small-cell lung cancer (LA-NSCLC). Whether consolidation chemotherapy (CCT) following CCRT is able to further improve the clinical outcome remains unclear. We therefore undertook a meta-analysis to compare the two regimens for LA-NSCLC.

Analysis of Cytokine Levers in Pleural Effusions of Tuberculous Pleurisy and Tuberculous Empyema.

The aim is to examine whether the interleukin-1β (IL-1β), IL-2, IL-6, tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor type-1 (PAI-1), and tissue plasminogen activator (t-PA) levels were different in pleural effusions of tuberculous pleurisy and tuberculous empyema. IL-1β, IL-2, IL-6, TNF-α, PAI-1, and t-PA levels in pleural fluids of 40 patients with tuberculous pleurisy and 38 patients with tuberculous empyema were measured. The levels of IL-1β, PAI-1, and t-PA in the pleural effusions were different between tuberculous pleurisy and tuberculous empyema; it could be helpful to differentiate the two diseases.

Analysis of Pneumonectomy for Benign Disease: A Single Institution Retrospective Study on 59 Patients.

Introduction: Pneumonectomy is the only curative treatment for some benign diseases but the operation is a challenging procedure. Herein, we present our experiences of pneumonectomy for 59 patients.

Methods: The medical records of 59 patients who undergone pneumonectomy for benign lung diseases from 2008 to 2013 at the Division of Thoracic Surgery in Beijing Chest Hospital were retrospectively reviewed.

Characteristics of trace elements in freshwater and seawater cultured pearls.

Trace elements in pearls have characteristic disciplines and functions. The previous work had paid attention to different characteristics of trace elements in freshwater and seawater cultured pearls, but only limited species of trace elements have been detected by former testing techniques and analysis methods, and the test results have not been further analyzed. With the advantages of detection in good capability and high speed, inductively coupled plasma mass spectrometer (ICP-MS) can concurrently test various trace and ultra-trace elements.

[Surgical treatment of pulmonary tuberculosis complicated with aspergilloma].

Objective: To investigate the surgical indications of pulmonary tuberculosis complicated with aspergilloma , and to reduce postoperative complications.

Methods: From 1993 to 2010, a total of 51 surgically treated patients in pulmonary tuberculosis complicated with aspergilloma were analyzed retrospectively. The common surgical procedure performed was lobectomy(60.

Treatment of 28 patients with sclerosing hemangioma (SH) of the lung.

Background: Sclerosing hemangioma (SH) of the lung is a kind of rare pulmonary tumor. Preoperative diagnosis of this tumor is difficult and it is now generally accepted that SH of the lung is benign lesions and surgical excision alone is curative. Herein, we present our experiences of treating 28 patients with SH.

[Study of prognostic factors in patients with stage I non-small cell lung cancer].

Objective: To analyze the prognostic factors for patients with stage I non-small cell lung cancer.

Methods: A total of 224 patients with stage I non-small cell lung cancer operated from 1999 to 2004 were retrospectively reviewed. The clinical profiles of age, gender, T grade, type of resection, tumor pathological typing, tumor cell differentiation and post-operative chemotherapy were analyzed by SPSS 13.

[Different treatment modalities of patients with stage III lung cancer].

Objective: In order to improve the survival-rates and study the long-term therapeutic effect of stage III lung cancer patients with different treatment modalities.

Methods: From 1995 to 2004, 1921 patients of stage III lung cancer treated at our hospital were retrospectively analyzed to compare the long-term therapeutic effect of different treatment modalities. There were 606 cases in the combined therapy group (mainly surgical with combined treatment of chemotherapy & radiotherapy), 317 cases in the surgery alone group and 998 cases in the non-surgical group.

[Impact of TNM staging and treatment mode on the prognosis of non-small cell lung cancer].

Objective: To study the impact of TNM staging and combined treatment mode on the survival of non-small cell lung cancer (NSCLC) patients.

Methods: From January 1997 to December 2002, 987 NSCLC patients were surgically treated in this hospital. Of those, 574 received combined modality therapy (surgery + chemotherapy/radiotherapy), while 413 underwent operation alone.