Publications by authors named "Zi-Tong Song"
Background: Genome-wide association studies have identified dozens of genomic loci for obesity. However, functional genes and their detailed genetic mechanisms underlying these loci are mainly unknown. In this study, we conducted an integrative study to prioritize plausibly functional genes by combining information from genome-, transcriptome- and proteome-wide association analyses.
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- Genome-wide association studies have linked numerous genetic variants to obesity, but many have yet to reveal their biological significance, particularly in the brain's role in obesity development.
- The researchers conducted proteome-wide association studies, finding 51 genes associated with obesity-related traits like body fat and waist circumference; these genes are involved in various metabolic processes and have potential for drug repurposing.
- The findings highlight the connection between genetic variants and brain protein abundance in obesity, suggesting these proteins could be important targets for new obesity treatments in the future.
Exome-Wide Sequencing Study Identified Genetic Variants Associated With Sarcopenic Obesity.
J Gerontol A Biol Sci Med Sci
April 2024
Sarcopenic obesity (SO) is an age-related disease characterized by the coexistence of excessive adiposity and low muscle mass or function. Although obesity and sarcopenia are heritable conditions, the genetic determinants of SO have not been fully understood. We conducted a large-scale exome-wide association analysis of SO in a sequenced sample of 2 887 cases and 113 284 controls and an imputed sample of 4 003 cases and 161 990 controls in the UK Biobank cohort.
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