Publications by authors named "Zi-Tong Cao"
Acta Pharmacol Sin
September 2024
Article Synopsis
- Depressive disorders are a significant global issue linked to inflammation, particularly increased after the COVID-19 pandemic, with the JAK-STAT signaling pathway not yet fully explored in this context.
- A recent analysis suggests that the JAK inhibitor tofacitinib may have potential beyond immune diseases by possibly preventing mood disorders.
- Research indicates that the JAK-STAT pathway is activated in depressive mouse models, leading to inflammation and synaptic issues, but tofacitinib shows promise in reversing these effects, highlighting its potential for treating depression.
Article Synopsis
- - The isatin group, known for its significance in drug discovery, was utilized to create new SHP1 inhibitors with fluorescent features for research purposes.
- - A newly synthesized compound demonstrated strong inhibition of SHP1 activity (IC of 11 ± 3 μM) and effectively reduced cell proliferation in MV-4-11 cells by 92% at 20 μM concentration.
- - The compound exhibited favorable fluorescent characteristics and low toxicity, allowing for blue fluorescent imaging in HeLa cells, which can advance our understanding of SHP1 in biological contexts and therapeutic applications.
