Publications by authors named "Zi-Rong Liu"
Risk of cardiovascular death in patients with hepatocellular carcinoma based on the Fine-Gray model.
World J Gastrointest Oncol
March 2024
Background: Hepatocellular carcinoma (HCC) is one of the most common types of cancers worldwide, ranking fifth among men and seventh among women, resulting in more than 7 million deaths annually. With the development of medical technology, the 5-year survival rate of HCC patients can be increased to 70%. However, HCC patients are often at increased risk of cardiovascular disease (CVD) death due to exposure to potentially cardiotoxic treatments compared with non-HCC patients.
View Article and Find Full Text PDFArticle Synopsis
- During cirrhosis, impaired liver function leads to reduced thrombopoietin (TPO) production and hypersplenism, which causes decreased platelet counts and an increased risk of bleeding.
- The study aimed to assess the effectiveness of recombinant human TPO (rhTPO) in treating low platelet counts (thrombocytopenia) in cirrhotic mice undergoing liver transplantation.
- Results showed that rhTPO treatment before and after surgery significantly improved platelet levels, while blocking TPO receptors worsened thrombocytopenia, indicating the crucial role of TPO in managing platelet counts in cirrhotic conditions.
Application value of mixed reality in hepatectomy for hepatocellular carcinoma.
World J Gastrointest Surg
January 2022
Article Synopsis
- Mixed reality (MR) technology improves liver surgery accuracy by providing better visualization of anatomy and tumor locations, especially since the rise of 5G communication.
- A study evaluated 95 patients who underwent hepatectomy for hepatocellular carcinoma, comparing outcomes between 38 MR-assisted surgeries and 57 traditional surgeries.
- Results showed that MR-assisted surgeries had shorter operation times, less bleeding, fewer postoperative complications, and shorter hospital stays, indicating MR's potential benefits in liver surgery.
Pre-treatment with FK506 reduces hepatic ischemia-reperfusion injury in rats.
Clin Res Hepatol Gastroenterol
April 2019
Aim: The study is aimed to investigate the protective effects and possible mechanism of tacrolimus (FK506) pre-treatment in hepatic ischemia-reperfusion injury in rats.
Methods: The rats were randomly assigned into four groups, which were S, IR, L and H group, and then all groups were subjected to 60min of 70% partial warm liver ischemia, except S group. Rats in the L and H group were pre-treated with two different doses FK506 at 60min before ischemia.
Liver tumor boundaries identified intraoperatively using real-time indocyanine green fluorescence imaging.
J Cancer Res Clin Oncol
January 2017
Purpose: Clear delineation between tumors and normal tissues is ideal for real-time surgical navigation imaging. We investigated applying indocyanine green (ICG) fluorescence imaging navigation using an intraoperative administration method in liver resection.
Methods: Fifty patients who underwent liver resection were divided into two groups based on clinical situation and operative purpose.
Aim: To investigate the therapeutic effects and mechanisms of interleukin (IL)-22 in liver regeneration in mice with concanavalin A (ConA)-induced liver injury following 70% hepatectomy.
Methods: Mice were injected intravenously with ConA at 10 μg/g body weight 4 d before 70% hepatectomy to create a hepatitis model, and recombinant IL-22 was injected at 0.125 μg/g body weight 30 min prior to 70% hepatectomy to create a therapy model.