Background: Gastric cancer (GC) is an aggressive malignant tumor with a high degree of heterogeneity, and its immune microenvironment is closely associated with tumor growth, development and drug resistance. Therefore, a classification system of gastric cancer based explicitly on the immune microenvironment context might enrich the strategy for gastric cancer prognosis and therapy.
Methods: A total of 668 GC patients were collected from TCGA-STAD ( = 350), GSE15459 ( = 192), GSE57303 ( = 70) and GSE34942 ( = 56) datasets.