Anesthesia/surgery activate MMP9 leading to blood-brain barrier disruption, triggering neuroinflammation and POD-like behavior in aged mice.

Anesthesia and surgery activate matrix metalloproteinase 9 (MMP9), leading to blood-brain barrier (BBB) disruption and postoperative delirium (POD)-like behavior, especially in the elderly. Aged mice received intraperitoneal injections of either the MMP9 inhibitor SB-3CT, melatonin, or solvent, and underwent laparotomy under 3 % sevoflurane anesthesia(anesthesia/surgery). Behavioral tests were performed 24 h pre- and post-operatively.

Effect of hydrothermal treatment on the rheological properties of xanthan gum.

In this study, the effect of hydrothermal treatment with different temperatures (120-180 °C) on the rheological properties of xanthan gum was evaluated. When the temperature of hydrothermal treatment was relatively low (120 °C), the rheological properties of the hydrothermally treated xanthan gum was similar to the untreated xanthan gum (pseudoplastic and solid-like/gel-like behavior). However, as the temperature of hydrothermal treatment was higher, the rheological properties of the hydrothermally treated xanthan gum changed greatly (e.

[Study on prediction model of Angelicae sinensis yield per unit in Min County].

Objective: To establish a prediction model of Angelicae sinensis yield per unit in Min County, and the forecasting information can be provided to correlated department and organization.

Methods: With the basis of the Angelicae sinensis yield statistics in Min County from 1995 to 2009 and weather data of development phase of each ten days, polynomial forecasting modeling was used and the stimulation forecasting of Angelicae sinensis yield in Min County was carried out.

Results: The results showed that the average accuracy of prediction model was reached to 97.

[Correlation analysis and evaluation of inorganic elements in Angelica sinensis and its correspondence soil from different regions].

Objective: Evaluate the relationship between the inorganic elements and the genuineness, invigoration efficacy of this medicinal material by qualitative and quantitative analysis of the inorganic elements in Angelica sinensis and its correspondence soil.

Methods: The contents of 14 kinds of inorganic elements from 40 samples from 4 main habits of Angelica sinensis in China were determined by the method of ICP-AES.

Results: In Angelica sinensis and its correspondence soil, significant positive correlations existed between each pair of Ca, Na, Ni.

Two new α-pinene derivatives from Angelica sinensis and their anticoagulative activities.

Two new α-pinene derivatives (1-2) were isolated from the aerial parts of Angelica sinensis. Their structures were determined by spectroscopic and chemical methods to be 6β,9-dihydroxy-(+)-α-pinene (1) and 9-hydroxy-(+)-α-pinene-6β-O-D-glucoside (2). In the anticoagulative assay, compounds 1 and 2 exhibited weak antithrombin activity and strong antiplatelet aggregation activity in vitro.

[Role of sodium cromoglycate in brain protection and its effects on tumor necrosis factor-alpha and interleukin-1beta after global cerebral ischemia-reperfusion injury in gerbils].

Objective: To investigate the role of sodium cromoglycate in brain protection and its effects on brain tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) expressions after global cerebral ischemia-reperfusion (IR) injury in gerbils.

Methods: Twenty-four healthy male gerbils were randomized into 3 equal groups, namely the sham-operated group with isolation of the bilateral carotid arteries but without occlusion, IR injury model group with bilateral carotid artery occlusion, and sodium cromoglycate treatment group with bilateral carotid artery occlusion and sodium cromoglycate administration at 25 mg/kg via the lingual vein as soon as the reperfusion start with another dose 1 h later. The animals were then sacrificed and the thalamus were removed, fixed in 10% formaldehyde and sliced for observation under light microscope with HE staining.