Publications by authors named "Zi-Mu Wang"
Article Synopsis
- The peroxisome is an organelle that plays a key role in various metabolic functions, and PEX3 is a crucial regulator of these processes.
- Researchers found that knocking out PEX3 specifically in heart cells (Pex3-KO) leads to an imbalance in redox homeostasis and disrupts heart cell growth and development.
- The study suggests that PEX3 aids in heart repair by affecting plasmalogen metabolism and influencing the AKT/GSK3β signaling pathway, indicating it could be an innovative target for therapies aimed at repairing heart damage.
Distinguishing between N6-methyladenosine (m6A)-associated long noncoding RNAs (lncRNAs) is crucial in non-small-cell lung cancer (NSCLC) patients. In this research, the prognosis and immunotherapeutic response of lncRNAs and m6A in NSCLC were examined. lncRNAs related to m6A were identified using co-expression analyses, and their prognostic impact on patients with NSCLC was assessed using univariate Cox regression analysis.
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- Adult mammals struggle with heart regeneration after injury, while neonatal mice can fully recover their heart tissue within a week.
- Understanding factors that enhance the growth of heart cells (cardiomyocytes) is vital for creating effective cardiac regeneration treatments.
- This study found that the protein MNK2 significantly boosts cardiomyocyte proliferation, both in lab settings and in living mice, by activating a pathway involving eIF4E and cyclin D1, highlighting MNK2 as a promising target for heart repair therapies.
Article Synopsis
- The neonatal heart has a strong ability to regenerate shortly after birth, and SGK3 (a protein kinase) is significantly active in the heart following myocardial infarction.
- This research investigates how SGK3 affects cardiomyocyte (heart cell) proliferation and cardiac repair during situations like heart surgery or oxygen deprivation.
- Results show that SGK3 promotes heart cell growth and recovery by regulating specific genes and proteins involved in the cell cycle and reducing certain negative regulators, highlighting its importance in heart regeneration after injury.
Article Synopsis
- Long noncoding RNAs (lncRNAs), particularly lncRNA FAF, are being studied for their significant roles in cardiovascular diseases, specifically in regulating protein expression in heart cells.
- Researchers performed high-throughput RNA sequencing to identify changes in lncRNAs and messenger RNAs in rats with acute myocardial infarction (AMI) compared to healthy controls, revealing that lncRNA FAF levels were decreased in the affected tissues.
- The study found that overexpressing lncRNA FAF could protect cardiomyocytes from apoptosis (cell death) during ischemia and hypoxia, potentially by enhancing the expression of FGF9, which also plays a protective role via specific signaling pathways.
Background: Synanthropic rats and mice share the same environment with humans and play an important role in epidemiology of toxoplasmosis; however, there is limited information about prevalence and genetic characterization of Toxoplasma gondii in synanthropic rats and mice in China.
Findings: In the present study, the prevalence and genetic characterization of T. gondii naturally infected synanthropic rodents (Rattus norvegicus and Mus musculus) were investigated in the urban area of Xuzhou city, Eastern China between June 2013 and August 2014.