The study focuses on identifying genetic risk factors for acute viral respiratory infections (ARI) and integrating traditional Chinese medicine (TCM) in their prevention through multi-omics analysis across various global populations.
Key susceptibility risk loci for influenza and COVID-19 were discovered, including COL15A1 in Europeans, and MAN1A2 and RAB1A in East Asians, highlighting the genetic diversity in ARI susceptibility.
Potential TCMs were identified to target the druggable key susceptibility loci, emphasizing the importance of genetic studies in informing drug development and preventive strategies for ARI.
The innate constitution is key in understanding disease mechanisms and tumor development, as highlighted by the theory of five movements and six climates.
Previous research shows a link between this theory and tumor types, suggesting its use in precision medicine for oncology.
This study aims to analyze the biological traits of different constitutions in a pan-cancer cohort and identify suitable anti-tumor drugs, leveraging data from various sources and machine learning techniques.