Publications by authors named "Zi-Lu Tang"

Article Synopsis
  • The study aimed to create and validate a radiomics model that predicts hidden locally advanced esophageal squamous cell carcinoma (LA-ESCC) using computed tomography (CT) data before treatment starts.
  • Researchers analyzed data from 574 patients and used various machine learning techniques to identify key radiomic features, ultimately developing a predictive tool that combines these features with clinical data.
  • The best model, a multilayer perceptron (MLP), showed high accuracy in distinguishing LA-ESCC, indicating that this approach can significantly help clinicians make better treatment decisions.
View Article and Find Full Text PDF

Purpose: The need for adjuvant therapy (AT) following neoadjuvant chemoimmunotherapy (nICT) and surgery in esophageal squamous cell cancer (ESCC) remains uncertain. This study aims to investigate whether AT offers additional benefits in terms of recurrence-free survival (RFS) for ESCC patients after nICT and surgery.

Methods: Retrospective analysis was conducted between January 2019 and December 2022 from three centers.

View Article and Find Full Text PDF

Functionalization of the C(sp )-H bonds of trialkylamines is challenging, especially for reactions at positions other than the α position. Herein, we report a method for β-C(sp )-H allylation of trialkylamines. In these reactions, which involve synergistic borane/palladium catalysis, an enamine intermediate is first generated from the amine via α,β-dehydrogenation promoted by B(C F ) and a base, and then the enamine undergoes palladium-catalyzed reaction with an allene to give the allylation product.

View Article and Find Full Text PDF

Objective: To explore the value of miR-129 in the diagnosis, treatment and prediction of the clinical prognosis of PCa by observing the correlation between miR-129 and the progression of the malignancy.

Methods: This retrospective analysis included 310 male patients who visited the Department of Urology of the General Hospital of Eastern Theater Command from January 2014 to January 2022, 80 as normal healthy men, 80 with BPH, and the other 150 with PCa treated by radical prostatectomy without chemotherapy, radiotherapy or androgen-deprivation therapy. We determined the miR-129 expression in the serum and prostatic tissue of all the subjects by real-time quantitative PCR (RT-qPCR), performed pathological grading of the primary cancerous and pericancerous (≥ 3 cm from the focus) prostate tissues from the 150 PCa patients, collected the demographic and clinical data on all the subjects, and analyzed the correlation of their demographic data with the clinical parameters.

View Article and Find Full Text PDF

Methods for C-H cyanation of pyridines are rare. Here, we report a method for C3-selective cyanation of pyridines by a tandem process with the reaction of an in situ generated dihydropyridine with a cyano electrophile as the key step. The method is suitable for late-stage functionalization of pyridine drugs.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionm4afsd5mnpbm4o745n2u34u7he2irsvd): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once