A one-pot electrochemical synthesis of 2-aminothiazoles from active methylene ketones and thioureas mediated by NHI.

The electrochemical preparation of 2-aminothiazoles has been achieved by the reaction of active methylene ketones with thioureas assisted by ᴅʟ-alanine using NHI as a redox mediator. The electrochemical protocol proceeds in an undivided cell equipped with graphite plate electrodes under constant current conditions. Various active methylene ketones, including β-keto ester, β-keto amide, β-keto nitrile, β-keto sulfone and 1,3-diketones, can be converted to the corresponding 2-aminothiazoles.

[Hereditary tendency of varicocele].

Objective: To investigate the hereditary tendency of varicocele.

Methods: We included in this study 112 varicocele patients, 117 direct male relatives of the patients, and 100 healthy men as controls. We compared the incidence of varicocele tween the direct relative group and the control group.

[Relationship of body mass index with cancer detection in prostate biopsy].

Objective: To investigate the relationship of body mass index with cancer detection on prostate biopsy.

Methods: A total of 168 patients undergoing a prostate biopsy were divided into obese and non-obese groups by BMI ≥ 25 or < 25. Then the differences of prostate-specific antigen (PSA) level, prostate volume, prostate cancer detection rate and pathology result between two groups.