Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis.

Objective: Endometrial carcinoma (EC) is a prevalent gynecological malignancy characterized by increasing incidence and mortality rates. This underscores the critical need for novel therapeutic targets. One such potential target is cell division cycle 20 (CDC20), which has been implicated in oncogenesis.

Orthodontic and Orthognathic Treatment Combined withSurgically Assisted Rapid Maxillary Expansion in an Adult Patient with a Hyperdivergent Skeletal Pattern.

In this case study, we report the successful treatment of a 35-year-old woman with a hyperdivergent skeletal pattern, open bite and severe transverse deficiency, exhibiting a skeletal Class III malocclusion. The treatment plan included 3D correction of these issues with surgically assisted rapid maxillary expansion (SARME) to solve the transverse deficiency, presurgical orthodontic treatment including aligning and levelling of the teeth in both arches, LeFort I osteotomy and bilateral sagittal split ramus osteotomy, and postsurgical correction of malocclusion. Orthodontic treatment was performed with labial brackets, and the patient achieved satisfactory occlusion and a significantly improved facial profile.

MicroRNA-328-5p Alleviates Macrophage Lipid Accumulation through the Histone Deacetylase 3/ATP-binding cassette transporter A1 pathway.

MicroRNA-328 (miR-328) was reported to protect against atherosclerosis, but its role in foam cell formation remains unknown. The aim of this study was to investigate the effect of miR-328-5p on macrophage lipid accumulation and the underlying mechanisms. The results showed that miR-328-5p expression was robustly decreased in oxidized low-density lipoprotein (ox-LDL)-treated macrophages.

Quantitative assessment of condyle positional changes before and after orthognathic surgery based on fused 3D images from cone beam computed tomography.

Objectives: To establish one method that can be used to quantitatively evaluate the condyle positional changes with 3D images in postoperative mandibular prognathism patients.

Materials And Methods: This is a retrospective observational study. Twenty-one patients who underwent bilateral sagittal split ramus osteotomy (BSSRO) were scanned with cone beam computed tomography (CBCT) for temporomandibular joints (TMJs) at 1 week preoperatively (T), 1 to 2 weeks (T), 3 months (T), 6 months (T), and 12 months (T) postoperatively.

Gastrodin combined with rhynchophylline inhibits cerebral ischaemia-induced inflammasome activation via upregulating miR-21-5p and miR-331-5p.

Background: The protective effects of gastrodin and rhynchophylline in ischaemic injury have been reported. However, the underlying mechanism and the effect of the combination of these two drugs in ischaemic injury remain unclear. Herein, we aimed to explore the effects of the combination of gastrodin and rhynchophylline on ischaemia-induced inflammasome activation as well as the underlying mechanism.

mutation in a Chinese family with unusual Crouzon syndrome.

Aim: To describe the clinical characteristics with genetic lesions in a Chinese family with Crouzon syndrome.

Methods: All five patients from this family were included and received comprehensive ophthalmic and systemic examinations. Direct sequencing of the gene was employed for mutation identification.

[Effect of segmental Le Fort I osteotomy and bilateral sagittal split ramus osteotomy on the condyle position in skeletal class III malocclusion patients].

Objective: To investigate the effect of segmental Le Fort I osteotomy and bilateral sagittal split ramus osteotomy (BSSRO) on the condyle position in skeletal class III malocclusion patients.

Methods: In this retrospective study, 19 patients with skeletal class III malocclusion who met the inclusion criteria were enrolled. All the patients underwent the segmental Le Fort I osteotomy and BSSRO.

[Three-dimensional evaluation of condylar morphology remodeling after orthognathic surgery in mandibular retrognathism by cone-beam computed tomography].

Objective: To evaluate the effect of orthognathic surgery on condylar morphology changes by comparing three-dimension surface reconstructions of condyles using cone-beam computed tomography (CBCT) data.

Methods: In the study, 18 patients with mandible retrognathism deformities were included and CBCT data of 36 temporomandibular joints were collected before surgery and 12 months after surgery. Condyles were reconstructed and superimposed pre- and post-operatively to compare the changes of condylar surfaces.

Screening Allelochemical-Resistant Species of the Alien Invasive Mikania micrantha for Restoration in South China.

To screen allelochemical-resistant species of the alien invasive weed Mikania micrantha, we studied the allelopathic inhibition effects of the leaf aqueous extract (LAE) of Mikania on seed germination and seedling growth of the 26 species native or naturalized in the invaded region in South China. Seed germination was more strongly negatively affected by LAE than seedling growth. Responses of seed germination and seed growth to LAE differed differently among the target species.

Modified method of recording and reproducing natural head position with a multicamera system and a laser level.

Introduction: As computer-assisted surgical design becomes increasingly popular in maxillofacial surgery, recording patients' natural head position (NHP) and reproducing it in the virtual environment are vital for preoperative design and postoperative evaluation. Our objective was to test the repeatability and accuracy of recording NHP using a multicamera system and a laser level.

Methods: A laser level was used to project a horizontal reference line on a physical model, and a 3-dimensional image was obtained using a multicamera system.

[Comparison of three surgical techniques for controlling nasal width after Le Fort I osteotomy].

Objective: To identify nasal width changes occurring after Le Fort I osteotomy and to compare prospectively the effect of three surgical techniques for controlling postoperative nasal width.

Methods: In the study, 79 patients (22 male and 57 female, mean age 23.2 ± 3.

TolC promotes ExPEC biofilm formation and curli production in response to medium osmolarity.

While a high osmolarity medium activates Cpx signaling and causes CpxR to repress csgD expression, and efflux protein TolC protein plays an important role in biofilm formation in Escherichia coli, whether TolC also responds to an osmolarity change to regulate biofilm formation in extraintestinal pathogenic E. coli (ExPEC) remains unknown. In this study, we constructed ΔtolC mutant and complement ExPEC strains to investigate the role of TolC in the retention of biofilm formation and curli production capability under different osmotic conditions.

[Establishment and accuracy examination of gyroscope for recording and transferring natural head position].

Objective: To build up and validate a system based on gyroscope to record human natural head position (NHP) and to transfer it into virtual surgical design system.

Methods: Three dimensional (3D) mechanical gyroscope and 3D design software were integrated in the system. The protocol for recording and transforming NHP included four steps.

[Clinical application of condylectomy via intraoral approach under computer assisted surgical navigation].

Objective: To assess the application of computer assisted surgical navigation in condylectomy via intraoral approach and its clinical results.

Methods: Eight patients aged from 16 to 56 were treated by condylectomy via intraoral approach under computer assisted surgical navigation. There were 6 female and 2 male.

[Association study of insulin-like growth factor-1 polymorphisms with extreme high myopia].

Objective: To investigate whether the polymorphisms of insulin-like growth factor-1 (IGF-1) gene and its regulatory regions are associated with extreme high myopia.

Methods: A case-control analysis of 302 subjects with extreme high myopia and 401 controls was undertaken. Genomic DNA was obtained from peripheral blood.

[Clinical application of transport distraction osteogenesis arthroplasty in the treatment of temporomandibular joint bony ankylosis].

Objective: To explore the clinical application of transport distraction osteogenesis arthroplasty (TDOAP) in the treatment of temporomandibular joint (TMJ) bony ankylosis.

Methods: From December 1999 to December 2011, a total of 73 patients (89 sides of TMJ) underwent TDOAP were included. There were 39 males and 34 females with a mean age of 19.

[Comparative analysis of two surgical techniques for controlling nasal width after Le Fort I osteotomy].

Objective: To compare the efficacy of two surgical techniques for controllong nasal width after Le Fort I osteotomy.

Methods: Fifty-five patients who received the Le Fort I osteotomy have been included in this study. They were randomly divided into 2 groups.

[The treatment of mandibular micrognathia secondary to temporomandibular joint ankylosis with distraction osteogenesis].

Objective: To evaluate the clinical effect of distraction osteogenesis for patients with mandibular micrognathia secondary to temporomandibular joint (TMJ) ankylosis.

Methods: 43 patients (aged from 2 to 61 years old) with mandibular micrognathia were treated with mandibular distraction osteogenesis. Two types of mechanical distraction were utilized in this study.

[Subjective outcomes after modified maxillomandibular advancement for the treatment of obstructive sleep apnea syndrome].

Objective: To evaluate subjective outcomes after modified maxillomandibular advancement(MMMA) for the treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS).

Methods: In the study, 15 patients underwent MMMA for the treatment of OSAHS and received presurgical and postsurgical polysomnography. A questionnaire was done pre- and postoperatively.

[Preliminary study of condylectomy via intraoral approach].

Objective: Condylectomy was performed to treat condylar osteoma or hyperplasia. Introduced two methods of condylectomy via intraoral approach and evaluated their clinical results.

Methods: Thirty-five patients, aging from 22 to 57.

[Novel RPGR gene mutation in a Chinese family with X-linked recessive retinitis pigmentosa].

Objective: To screen the mutation in the RPGR gene in a large Chinese family with X-linked recessive retinitis pigmentosa (RP) and to describe the phenotype in affected males and female carriers.

Methods: Ophthalmic examinations were performed in 77 family members of a RP pedigree to identify affected individuals. Polymerase chain reaction (PCR) and direct sequencing were used for screening of mutations in RPGR gene exon ORF15.

[Surgical management of hemifacial microsomia: a report of 24 cases].

Objective: To investigate the therapeutic effect of combined treatment for hemifacial microsomia (HFM).

Methods: From July 1991 to August 2006, 24 consecutive patients with HFM were retrospectively analyzed. They underwent orthognathic surgery, free flap transplantation, Medpor implant, distraction osteogenesis.

[Clinical study on modified maxillomandibular advancement for the treatment of obstructive sleep apnea syndrome].

Objective: To evaluate the modified maxillomandibular advancement (MMMA) technique for the treatment of obstructive sleep apnea syndrome (OSAS) in yellow race of convex profile.

Methods: Eight patients underwent MMMA for the treatment of OSAHS. All the patients underwent pre-surgical and postsurgical polysomnography, cephalometric analysis and objective results assessment.

[Effect of icariin on the mRNA expressions of Cbfalpha1, BMP2, BMP4 in rat osteoblasts].

Objective: To investigate the effect of icariin on the proliferation, differentiation, and the mRNA expressions of Cbfalpha1, BMP2, BMP4 of rat osteoblasts.

Methods: Primary rat osteoblastic cells were obtained by sequentia collagenase/trypsin enzyme digestion from calvarial bones of new born (within 24 h) SD rats and were identified by Alkaline phosphatase and alizarin red staining. The passage 3-5 cells were treated with icariin at the concentration of 0 mol/L, 10(-8) mol/L, 10(-7) mol/L, 10(-6) mol/L, 10(-5) mol/L, 10(-4) mol/L for 24 h, 48 h, 72 h, and the proliferation of the cells was measured by CCK-8 assay.

[Distraction osteogenesis of the mandibular ramus in hemifacial microsomia].

Objective: To study the application of distraction osteogenesis (DO) of the mandibular ramus in hemifacial microsomia.

Methods: From 1999 to 2006, 15 patients with hemifacial microsomia were treated with DO of the ramus, including 12 cases of children and juveniles, 3 cases of grown-ups. Maxillary Le Fort I osteotomy, unilateral sagittal split ramus osteotomy, genioplasty and free scapular flaps were selected to perform on the first or secondary stage of treatment.