Publications by authors named "Zi-Lang Chen"
Article Synopsis
- The study investigates the relationship between gene polymorphisms and expression of NRG1, DAOA, and DISC1 in individuals at ultra-high risk (UHR) for psychosis in the Chinese Han population, as prior research had not explored this demographic.
- Researchers analyzed samples from 18 UHR individuals, their first-degree relatives, first-episode psychosis cases, and healthy controls, examining various genetic markers and mRNA levels.
- Findings indicate that variations in the DAOA gene are linked to UHR susceptibility, and there are interactions between the NRG1, DAOA, and DISC1 genes; notably, NRG1 expression was significantly reduced in the UHR group compared to controls, suggesting its potential role as a
Objective: The consequences and impact of violent behavior in schizophrenia are often serious, and identification of risk factors is of great importance to achieve early identification and effective management.
Methods: This follow-up study sampled adult patients with schizophrenia in primary mental health care in a rural area of southern China, in which 491 participants completed a comprehensive questionnaire at baseline and the 2-year follow-up. Sociodemographic, clinical and psychological assessment data were collected from all participants.
Few studies have examined the clozapine in cohort studies of Chinese patients with schizophrenia in rural primary care. The objective of this two-year cohort study was to describe the usage of clozapine and investigate and identify the demographic, clinical correlations and risk variables which affect the use of clozapine in patients with schizophrenia. A random cluster sampling technique was used, and participants were collected from China National Psychiatric Management System (CNPMS).
View Article and Find Full Text PDFObjective: Quality of life (QoL) has been always an important way to evaluate the outcomes of schizophrenia, but there have been few previous longitudinal studies and few in middle-income countries. This study aimed to explore the QoL in Chinese patients with schizophrenia treated in primary mental health care and the risk factors of QoL over time.
Methods: Patients with schizophrenia treated in primary mental health care in rural/regional areas in Luoding, Guangdong, PR China, were evaluated with an extended questionnaire including the Chinese version of the World Health Organization Quality of Life (WHOQOL-BREF) at baseline and 2-year follow-up.
Objective: To date, no study has specifically compared antipsychotic-free patients with schizophrenia living in the community between rural and urban areas. This study examined the rural-urban differences among antipsychotic-free community-dwelling individuals with schizophrenia in China.
Methods: Data on 1,365 community-dwelling patients with schizophrenia (n = 742 in a rural area and n = 623 in an urban area) with diagnoses according to DSM-IV or ICD-10 were collected by interviews during 2013-2014 and 2015-2016.