Publications by authors named "Zi-Heng Zheng"
Article Synopsis
- Catheter ablation (CA) is an effective first-line treatment for atrial fibrillation (AF), and a meta-analysis was conducted to compare its long-term outcomes and quality of life (QoL) with antiarrhythmic drugs (AADs).
- The analysis included 20 randomized controlled trials with over 5,400 participants, revealing that CA significantly reduced the risk of all-cause death and cardiovascular hospitalization compared to AADs, though it increased the risk of cardiac tamponade.
- Both CA and AADs improved QoL, with CA showing better outcomes on the Medical Outcomes Study SF-36 for both physical and mental health components, along with significant improvements from baseline to follow-up.
Article Synopsis
- Early repolarization syndrome (ERS) is linked to genetic mutations, with the study focusing on the unclear role of the GPD1-L mutation P112L in its development.
- Whole-genome sequencing and various laboratory techniques demonstrated that the P112L mutation resulted in lower protein expression of GPD1-L and a significant reduction in sodium current activation (INa) in transfected cells.
- The findings indicate that the GPD1-L P112L mutation may contribute to the pathogenesis of ERS by impairing GPD1-L function and altering its cellular distribution.
Article Synopsis
- - The study investigates the role of the DPP6-L747P variant in early repolarization syndrome (ERS) linked to sudden cardiac arrest, building on previous findings about DPP6's involvement in idiopathic ventricular fibrillation.
- - Researchers identified the DPP6-L747P genetic variant through whole genome sequencing in four Chinese families and conducted functional experiments to understand its effects on potassium currents in HEK293 cells.
- - Results showed that the DPP6-L747P variant leads to increased macroscopic currents and alters activation and inactivation properties of DPP6, suggesting it enhances potassium current activity, potentially contributing to ERS-related cardiac events.
Background: Interleukin-1 (IL-1) played a role in the occurrence and development of atherosclerosis and cardiovascular events. However, the association between IL-1 blockage treatment and reducing of cardiovascular risk remains poorly defined.
Hypothesis: IL-1 blockage treatment reduce the risk and incidence rate of overall major adverse cardiovascular events (MACE), all-cause death, acute myocardial infarction(MI), unstable angina and heart failure.
Article Synopsis
- Abnormalities in heart ion channels can lead to a condition called early repolarization syndrome (ERS), which affects how the heart resets after each beat.
- Researchers studied genes from families with ERS to see how certain mutations in the SCN1Bβ gene impacted heart function.
- They found that specific mutations increased a type of potassium current, which might help explain why people in these families have ERS.