Publications by authors named "Zi-Hao Kong"
Glycogen synthase kinase 3β (GSK-3β) is a potential therapeutic target for the treatment of a variety of human diseases. Here, we report the design and synthesis of a series of thieno[3,2-c]pyrazol-urea derivatives and evaluation of their GSK-3β inhibitory activity. Among these analogues, the compound without substitution on terminal phenyl ring (3a) was found to be the most potent GSK-3β inhibitor with an IC of 74.
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- - In Malaysia, bananas are the second most produced fruit and significant for exports, but a bacterial wilt disease outbreak affected a plantation in Teluk Intan, impacting 5 out of 6.6 hectares.
- - The disease manifests through leaf wilting, plant decay, discoloration, and fruit rotting, leading researchers to sample and sterilize affected banana tissues for bacterial analysis.
- - Five unique bacterial colonies were identified through 16S rRNA gene sequencing, with two strains (UTAR-BC1 and UTAR-BC2) showing complete genetic similarity, highlighting the ongoing investigation into bacterial pathogens affecting bananas in Malaysia.
Background: There is a lack of sufficient evidence on whether mixed-type differentiated predominant early gastric cancer (MD-EGC) can be treated endoscopically by referring to the criteria for differentiated-type early gastric cancer (EGC). This study aims to evaluate the efficacy of endoscopic submucosal dissection (ESD) in MD-EGC.
Methods: Patients with differentiated-type EGC treated with ESD first from January 2015 to June 2021 were reviewed, including MD-EGC and pure differentiated-type EGC (PD-EGC).