[Potentiating effect and mechanism of extract of Jingfang Granules on activation of macrophages].

This study aimed to explore the potentiating effect and mechanism of the extract of Jingfang Granules(JFG) on the activation of macrophages. The RAW264.7 cells were treated with JFG extract and then stimulated by multiple agents.

Synthesis of benzo[][1,5]diazocin-6(5)-one derivatives the Cu-catalysed oxidative cyclization of 2-aryl-1-indoles with 1,1-enediamines.

A novel protocol for the synthesis of highly functionalized benzo[][1,5]diazocin-6(5)-one derivatives (BDCOs, 4 and 5) from 2-aryl-1-indoles and 1,1-enediamines was developed a complex cascade of reactions including regioselective free radical oxidation, the 1,2-addition of imine, imine-enamine tautomerization, intramolecular cyclization, and ring expansion. The cascade reaction was enabled by refluxing a mixture of two substrates in the presence of di--butyl peroxide (DTBP) as an oxidant and anhydrous CuI as a catalyst in toluene under argon protection. Consequently, a series of BDCOs (4 and 5) were synthesized with high regioselectivity in good yield.

Cu-Catalyzed decarboxylative annulation of -substituted glycines with 3-formylchromones: synthesis of functionalized chromeno[2,3-]pyrrol-4(1)-ones.

A novel protocol was developed for preparing functionalized chromeno[2,3]pyrrol-4(1)-ones 3 (CMPOs) from 3-formylchromones with -substituted glycine derivatives. The method entailed decarboxylative annulation of the acyl group of 3-formylchromones by simply heating a mixture of substrates 1-2 and toluene oxidized by 2-di--butyl peroxide (DTBP) and catalyzed by CuBr. As a result, a series of CMPOs 3 were produced a cascade reaction.

Anti-inflammatory flavonoid derivatives from the heartwood of T. Chen.

Two pairs of flavonoid enantiomers (/ and /) together with three known analogues (-) were isolated from the heartwood of T. Chen. Their structures were elucidated by extensive spectroscopic analysis (1 D and 2 D NMR, UV, IR, and HRMS) and experimental and calculated ECD data.

An Environmentally Benign Multicomponent Cascade Reaction of 3-Formylchromones, 2-Naphthols, and Heterocyclic Ketal Aminals: Site-Selective Synthesis of Functionalized Morphan Derivatives.

A novel protocol has been developed for the preparation of highly functionalized 2-azabicyclo[3.3.1]nonane (morphan) derivatives by the interesting three-component cascade reaction of 3-formylchromones, 2-naphthol, and heterocyclic ketal aminals (HKAs) in the ionic liquid [BMIM]PF promoted by the organic base EtN.