Publications by authors named "Zi-Fang Li"
Serum and glucocorticoid-inducible kinase 3 (SGK3) is involved in maintaining podocyte function by regulating the protein levels of podocin and CD2-associated protein. Nephrin is also one of the slit diaphragm proteins of podocytes, but whether SGK3 participates in podocyte injury by regulating the levels of nephrin remains unclear. In this study, we focused on whether SGK3 affects nephrin levels and the mechanisms involved in the same.
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- The study assessed adverse events (AEs) related to immune checkpoint inhibitors (ICIs) in a mainly Chinese population by analyzing clinical trials up to September 2019.
- It included 13 trials with 1063 patients, revealing high incidences of treatment-related AEs (84.1%) and immune-related AEs (43.3%), with a notable increase in severe AEs when combining ICIs with chemotherapy.
- Specific AEs were identified for different ICIs, and while most AEs were mild and manageable, combining ICIs with other treatments raises concerns for more severe side effects.
Podocyte damage is commonly accompanied by destabilization of the podocalyxin (PC)/ezrin complex. Serum- and glucocorticoid-inducible kinase 3 (SGK3) plays a role in the maintenance of podocyte function, but the details of this role are poorly understood. Herein we demonstrated that SGK3 and its downstream target protein neural precursor cell expressed developmentally downregulated protein 4 subtype 2 (Nedd4-2) triggered PC and ezrin interaction.
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