Publications by authors named "Zi-Chun Huang"
Background: In recent years, many studies have reported the relationship between non-alcoholic fatty liver disease (NAFLD) and sex hormones, especially total testosterone (TT) and sex hormone-binding globulin (SHBG). However, the relationship between sex hormones and the severity of NAFLD is still unclear.
Methods: PubMed, Embase, Cochrane Library, Web of Science, WanFang, China National Knowledge Infrastructure and VIP databases were searched for relevant studies from inception to 31 August 2021.
Article Synopsis
- The study investigates whether quercetin can reduce fibrogenic responses in endometrial stromal cells by boosting microRNA-145 (miR-145) levels and affecting the TGFβ1/Smad2/Smad3 signaling pathway, aiming to find new treatment strategies for endometrial fibrosis.
- Methods included measuring the expression of miR-145 and TGFβ receptor 2 (TGFBR2) using RT-qPCR, assessing proteins related to fibrosis with immunofluorescence and western blot, and using dual-luciferase reporter assays to confirm the interaction between miR-145 and TGFBR2.
- Results showed that quercetin effectively upregulates miR