Quaking Deficiency Amplifies Inflammation in Experimental Endotoxemia the Aryl Hydrocarbon Receptor/Signal Transducer and Activator of Transcription 1-NF-κB Pathway.

Macrophages, characterized by considerable diversity and plasticity, play a crucial role in a broad spectrum of biological processes, including inflammation. However, the molecular mechanisms underlying the diverse phenotypes of macrophages are not well defined. Here, we show that the RNA-binding protein, quaking (QKI), dynamically modulates macrophage polarization states.

[Determination of the content of phloridzin using reversed-phase high-performance liquid chromatography].

Objective: To establish a reversed-phase high-performance liquid chromatographic (RP-HPLC) method for determination of phloridzin content.

Methods: A RP-HPLC method was established for determination of phloridzin using an Inertsil ODS-3 (4.6×150 mm, 5 µm) column with the detection wavelength of 288 nm, flow rate of 1.