Publications by authors named "Zi-Chao Lv"
Objective- Vascular adventitia encompasses progenitors and is getting recognized as the major site of inflammation in early stage of atherosclerosis. However, the cellular atlas of the heterogeneous adventitial cells, the intercellular communication, the cellular response of adventitia to hyperlipidemia, and its contribution to atherosclerosis have been elusive. Approach and Results- Single-cell RNA sequencing was applied to wt (wild type) and ApoE (apolipoprotein E)-deficient aortic adventitia from 12-week-old C57BL/6J mice fed on normal laboratory diet with early stage of atherosclerosis.
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- Right ventricle (RV) function is crucial for assessing prognosis in patients with pulmonary arterial hypertension (PAH), and inhaled iloprost is a treatment option for severe cases and acute RV failure.
- A study with 69 PAH patients showed that a 5 μg inhalation of iloprost significantly improved RV ejection fraction (RVEF), stroke volume, and reduced pulmonary vascular resistance (PVR) 20 minutes after administration.
- The improvement in RVEF was directly correlated with PVR reduction in patients with idiopathic PAH, but not in those with PAH related to connective tissue disease or congenital heart disease.
Background: Previous studies have shown that elevated total bilirubin was associated with advanced heart failure, yet no study has ascertained the predictive value of direct serum bilirubin (DBIL) in idiopathic pulmonary arterial hypertension (IPAH). This study aimed to investigate the predictive value of both baseline and follow-up DBIL in patients with IPAH.
Methods: Serum DBIL was measured in 404 IPAH patients at enrollment.
Background: Aberrant transforming growth factor (TGF)-β signaling is involved in the pathogenesis of pulmonary arterial hypertension (PAH). We aimed to investigate the predictive value of the upstream ligand of TGF-β signaling (TGF-β1) on long-term mortality and the clinical characteristics of patients with idiopathic pulmonary arterial hypertension (IPAH) and heritable PAH (HPAH).
Methods And Results: Plasma TGF-β1 levels were measured in 151 IPAH and 65 HPAH patients retrospectively enrolled between January 2008 and March 2013, and compared to 61 healthy subjects.