Publications by authors named "Zi-Bo Xiong"
Introduction: Restless legs syndrome (RLS) is a common neurological sensorimotor disorder among patients with end stage renal disease. This clinical trial aimed to provide evidence on the efficacy and safety of pramipexole in patients with uremic RLS receiving peritoneal dialysis (PD).
Methods And Analysis: This is a 12-week, multicentre, randomised, double-blind, placebo-controlled clinical trial.
Research on the association between cognitive impairment (CI) and peritoneal dialysis (PD)-related peritonitis is limited. Therefore, we investigated whether CI contributed to the risk of PD-related peritonitis.This prospective cohort study enrolled 458 patients from 5 PD centers between 1 March 2013, and 30 November 2013, and continued until 31 May 2016.
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- Rosiglitazone, commonly used to treat Type 2 diabetes, has been found to provide cardioprotection against ischemia-reperfusion (I/R) injury, though the exact mechanisms were previously unclear.
- A study showed that mice pretreated with rosiglitazone exhibited less heart damage and reduced cardiac cell death after I/R, and the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling pathway played a crucial role in this protective effect.
- Inhibition of the PI3-K pathway using wortmannin negated the cardioprotective benefits of rosiglitazone, highlighting its importance as a potential therapeutic target for reducing myocardial I/R injury.