IEEE J Biomed Health Inform
April 2022
ncRNAs play important roles in a variety of biological processes by interacting with RNA-binding proteins. Therefore, identifying ncRNA-protein interactions is important to understanding the biological functions of ncRNAs. Since experimental methods to determine ncRNA-protein interactions are always costly and time-consuming, computational methods have been proposed as alternative approaches.
View Article and Find Full Text PDFLong non-coding RNAs (LncRNAs) are a type of RNA with little or no protein-coding ability. Their length is more than 200 nucleotides. A large number of studies have indicated that lncRNAs play a significant role in various biological processes, including chromatin organizations, epigenetic programmings, transcriptional regulations, post-transcriptional processing, and circadian mechanism at the cellular level.
View Article and Find Full Text PDFBrief Bioinform
September 2021
Noncoding RNAs (ncRNAs) play crucial roles in many biological processes. Experimental methods for identifying ncRNA-protein interactions (NPIs) are always costly and time-consuming. Many computational approaches have been developed as alternative ways.
View Article and Find Full Text PDFLong non-coding RNAs (lncRNAs) play an important role in serval biological activities, including transcription, splicing, translation, and some other cellular regulation processes. lncRNAs perform their biological functions by interacting with various proteins. The studies on lncRNA-protein interactions are of great value to the understanding of lncRNA functional mechanisms.
View Article and Find Full Text PDFEukaryotic cells contain numerous components, which are known as subcellular compartments or subcellular organelles. Proteins must be sorted to proper subcellular compartments to carry out their molecular functions. Mis-localized proteins are related to various cancers.
View Article and Find Full Text PDFLong non-coding RNAs (lncRNAs) play important roles in various biological processes, where lncRNA-protein interactions are usually involved. Therefore, identifying lncRNA-protein interactions is of great significance to understand the molecular functions of lncRNAs. Since the experiments to identify lncRNA-protein interactions are always costly and time consuming, computational methods are developed as alternative approaches.
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