Low miR-224-5p in exosomes confers colorectal cancer 5-FU resistance by upregulating S100A4.

This study aimed to identify molecular markers that mediate 5-fluorouracil (5-FU) resistance in colorectal cancer (CRC). Exosomes from 5-FU resistant CRC cells (HCT-15/FU) significantly enhanced the resistance to 5-FU and the malignant properties of HCT-15 cells. Double screening of miRNAs in CRC cell-exosomes and serum-exosomes from clinical CRC patients revealed that miR-224-5p was expressed at significantly lower levels in the 5-FU resistant type than in the 5-FU sensitive type.

Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney, and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways.

Background: Jianpi Gushen Huayu Decoction (JPGS) has been used to clinically treat diabetic nephropathy (DN) for many years. However, the protective mechanism of JPGS in treating DN remains unclear.

Aim: To evaluate the therapeutic effects and the possible mechanism of JPGS on DN.

Mechanical study of alisol B 23-acetate on methionine and choline deficient diet-induced nonalcoholic steatohepatitis based on untargeted metabolomics.

Alisol B 23-acetate (AB23A) has been demonstrated to have beneficial effects on nonalcoholic steatohepatitis (NASH). However, the mechanisms of AB23A on NASH remain unclear. This study aimed to investigate the mechanisms underlying the metabolic regulatory effects of AB23A on NASH.

A silver catalyst with a high-energy surface prepared by plasma spraying for the hydrogen evolution reaction.

A self-supported silver electrode was prepared by plasma spraying and used for catalysing the hydrogen evolution reaction. Thanks to the non-equilibrium synthetic conditions, the silver catalyst exposes high-energy (200) crystal planes, which enhance the adsorption of hydrogen and improve the intrinsic catalytic activity. As a result, the silver catalyst delivers an overpotential of 349 mV at 10 mA cm, which was much lower than those of Ag foil (742 mV) and commercial Ag powder (657 mV).

The catalytic oxidation performance of toluene over the Ce-Mn-O catalysts: Effect of synthetic routes.

Ce-Mn-O catalysts were synthesized by impregnation (CM-IM), co-precipitation (CM-CP), citrate sol-gel (CM-SG) and hydrothermal (CM-HT) methods. The synthesis methods exhibited a great impact on the physicochemical properties of catalysts, resulting in different catalytic activity. The catalytic oxidation activity of toluene followed the sequence: CM-HT (T: 234 °C; T: 246 °C) > CM-SG (T: 242 °C; T: 249 °C) > CM-CP (T: 243 °C; T: 259 °C) > CM-IM (T: 251 °C; T: 261 °C), which was consistent with the sequence of surface relative percentage of C, Ce, Mn, O and r values.