This study aimed to identify molecular markers that mediate 5-fluorouracil (5-FU) resistance in colorectal cancer (CRC). Exosomes from 5-FU resistant CRC cells (HCT-15/FU) significantly enhanced the resistance to 5-FU and the malignant properties of HCT-15 cells. Double screening of miRNAs in CRC cell-exosomes and serum-exosomes from clinical CRC patients revealed that miR-224-5p was expressed at significantly lower levels in the 5-FU resistant type than in the 5-FU sensitive type.
View Article and Find Full Text PDFBackground: Jianpi Gushen Huayu Decoction (JPGS) has been used to clinically treat diabetic nephropathy (DN) for many years. However, the protective mechanism of JPGS in treating DN remains unclear.
Aim: To evaluate the therapeutic effects and the possible mechanism of JPGS on DN.
Alisol B 23-acetate (AB23A) has been demonstrated to have beneficial effects on nonalcoholic steatohepatitis (NASH). However, the mechanisms of AB23A on NASH remain unclear. This study aimed to investigate the mechanisms underlying the metabolic regulatory effects of AB23A on NASH.
View Article and Find Full Text PDFA self-supported silver electrode was prepared by plasma spraying and used for catalysing the hydrogen evolution reaction. Thanks to the non-equilibrium synthetic conditions, the silver catalyst exposes high-energy (200) crystal planes, which enhance the adsorption of hydrogen and improve the intrinsic catalytic activity. As a result, the silver catalyst delivers an overpotential of 349 mV at 10 mA cm, which was much lower than those of Ag foil (742 mV) and commercial Ag powder (657 mV).
View Article and Find Full Text PDFCe-Mn-O catalysts were synthesized by impregnation (CM-IM), co-precipitation (CM-CP), citrate sol-gel (CM-SG) and hydrothermal (CM-HT) methods. The synthesis methods exhibited a great impact on the physicochemical properties of catalysts, resulting in different catalytic activity. The catalytic oxidation activity of toluene followed the sequence: CM-HT (T: 234 °C; T: 246 °C) > CM-SG (T: 242 °C; T: 249 °C) > CM-CP (T: 243 °C; T: 259 °C) > CM-IM (T: 251 °C; T: 261 °C), which was consistent with the sequence of surface relative percentage of C, Ce, Mn, O and r values.
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