The Jieduquyuziyin Prescription alleviates systemic lupus erythematosus by modulating B cell metabolic reprogramming via the AMPK/PKM2 signaling pathway.

Ethnopharmacological Relevance: The Jieduquyuziyin prescription (JP) is an enhanced formula derived from the "Sheng Ma Bie Jia Tang" in the Golden Chamber. JP is an empirical formula approved for use in the treatment of systemic lupus erythematosus (SLE) in hospitals across China, demonstrating notable therapeutic effects. It has been shown to suppress B cell activation and alleviate symptoms; however, its underlying mechanism remains unclear.

Identification of a outer membrane porin required for intracellular replication.

is a gram-negative, obligate intracellular pathogen that causes human Q fever. Within host cells, proliferates in a spacious, acidic, lysosome-derived -containing vacuole (CCV) by a process that requires the Dot/Icm type IVB secretion system to deliver effectors that manipulate host cell functions. A previous transposon mutagenesis screen identified the gene as being important for intracellular replication of .

Radiotherapy dose prediction using off-the-shelf segmentation networks: A feasibility study with GammaPod planning.

Background: Radiotherapy requires precise, patient-specific treatment planning to achieve high-quality dose distributions that improve patient outcomes. Traditional manual planning is time-consuming and clinically impractical for performing necessary plan trade-off comparisons, including treatment modality selection, prescription dose settings, and organ at risk (OAR) constraints. A time-efficient dose prediction tool could accelerate the planning process by guiding clinical plan optimization and adjustments.

Advancing lung cancer diagnosis: Combining 3D auto-encoders and attention mechanisms for CT scan analysis.

Objective: The goal of this study is to assess the effectiveness of a hybrid deep learning model that combines 3D Auto-encoders with attention mechanisms to detect lung cancer early from CT scan images. The study aims to improve diagnostic accuracy, sensitivity, and specificity by focusing on key features in the scans.

Materials And Methods: A hybrid model was developed that combines feature extraction using 3D Auto-encoder networks with attention mechanisms.

Changes in Plant Biomass Are Driven by Persisting Plant Species, but Species Gains Drive Nematode Carbon Dynamics.

Global change drivers, such as shrub encroachment, alter above- and belowground communities, and the consequences of these changes for ecosystem functioning are largely unknown. We used the modified Price equation to quantify how the presence of shrubs alters the richness, composition, and abundance of plant and nematode communities and the resulting effects on ecosystem functioning (i.e.

Synthesis and Antifungal Activity of Aldehydes-Thiourea Derivatives as Promising Antifungal Agents Against Postharvest Gray Mold Disease.

Gray mold disease is caused by Botrytis cinerea, which could severely reduce the production yield and quality of tomatoes. To explore more potential fungicides with new scaffolds for controlling gray mold disease, 10 aldehydes-thiourea derivatives were designed, synthesized, and assayed for inhibitory activity against three plant pathogenic fungi. The preliminary antifungal assay suggested that some title derivatives showed moderate to good antifungal activity against B.

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs.

The tRNA methyltransferase 1 (TRMT1) enzyme catalyzes the N2,N2-dimethylguanosine (m2,2G) modification in tRNAs. Intriguingly, vertebrates encode an additional tRNA methyltransferase 1-like (TRMT1L) paralog. Here, we use a comprehensive tRNA sequencing approach to decipher targets of human TRMT1 and TRMT1L.

The genetic association between polycystic ovary syndrome and the risk of hypertensive disorders of pregnancy: A Mendelian randomization study.

Objective: In observational studies, polycystic ovary syndrome (PCOS) has been associated with an increased risk of hypertensive disorders of pregnancy (HDPs); however, the causality between these conditions remains to be determined. This study aimed to investigate the causal relationship between PCOS and HDPs.

Methods: This genome-wide association study (GWAS), conducted from November to December 2023, aimed to investigate the causal relationships between PCOS and HDPs, gestational hypertension and preeclampsia/eclampsia via two-sample Mendelian randomization (MR) analysis.

Lanthanide (Substituted-)Cyclopentadienyl Bis(phosphinimino)methanediide Complexes: Synthesis and Characterization.

Design and synthesis of high-performance single-molecule magnets (SMMs) have long been a research focus. Inspired by the best dysprosium(III) metallocene SMMs and dysprosium(III) bis(methanediide) SMMs, we assumed dysprosium SMMs, which had electrical neutrality by combining the two types of ligands. As the Dy center is coordinated by one (substituted-)cyclopentadienyl (Cp) ligand and one methanediide ({C(PPhNSiMe)}) ligand on the axial sites, this ideal structure with linear C-Dy-Cp would strengthen the magnetic anisotropy and exhibit excellent SMM properties.

A prior-knowledge-guided dynamic attention mechanism to predict nocturnal hypoglycemic events in type 1 diabetes.

Nocturnal hypoglycemia is a critical problem faced by diabetic patients. Failure to intervene in time can be dangerous for patients. The existing early warning methods struggle to extract crucial information comprehensively from complex multi-source heterogeneous data.

Synthesis and anti-fungi/oomycetes activity of cuminic acid derivatives containing thiourea group for crop protection.

In search of novel natural product-based fungicides,twenty-four cuminic acid derivatives containing thiourea group were synthesized and characterized by 1H-NMR, 13C-NMR and HRMS spectra. The anti-fungi/oomycete activity bioassay showed that the some of the title compounds displayed moderate to good anti-fungi activity against Botryosphaeria dothidea (B. dothidea), Sclerotinia sclerotiorum (S.

Rhodium(III)-catalyzed direct C-H activation of 2-aryl-3-indoles: a strategy for 4-heteroaryl pyrazole synthesis.

A novel protocol for synthesizing 4-heteroaryl pyrazoles from readily available 2-aryl-3-indoles and diazopyrazolones through the rhodium(III)-catalyzed C-H bond activation has been achieved. This redox-neutral strategy features powerful reactivity, tolerates various functional groups, and proceeds with moderate yields under mild reaction conditions.

p38α-eIF6-Nsun2 axis promotes ILC3's rapid response to protect host from intestinal inflammation.

Group 3 innate lymphoid cells (ILC3s) are important for maintaining gut homeostasis. Upon stimulation, ILC3s can rapidly produce cytokines to protect against infections and colitis. However, the regulation of ILC3 quick response is still unclear.

Comparative extraction of antioxidant proteins from whole frogs ( Pollas).

The forest frog ( Pollas) is a traditional medicinal source rich in active protein compounds. In order to extract these compounds, six extraction methods were employed, including freeze-thaw and stirring techniques. Three different solvents were utilized in this process: 0.

Electronic Health Records Sharing Based on Consortium Blockchain.

In recent years, Electronic health records (EHR) has gradually become the mainstream in the healthcare field. However, due to the fact that EHR systems are provided by different vendors, data is dispersed and stored, which leads to the phenomenon of data silos, making medical information too fragmented and bringing some challenges to current medical services. Therefore, in view of the difficulties in sharing EHR between medical institutions, the risk of privacy leakage, and the lack of EHR usage control by patients, an EHR sharing model based on consortium blockchain is proposed in this paper.

Integrative analysis of non12-hydroxylated bile acid revealed the suppressed molecular map of alternative pathway in nonalcoholic steatohepatitis mice.

Bile acids (BAs) are significantly altered in the liver and serum of patients with nonalcoholic steatohepatitis (NASH). However, the underlying mechanisms of these changes, particularly BA alternative pathways (BAP) responsible for non12-OH BAs, remain unclear. RNA-seq data were initially analyzed to reveal the changes of gene expression in NASH patients.

Physicochemical and processing properties and in vitro fecal fermentation characteristics of Prunus cerasifera Ehrhart polysaccharide.

Prunus cerasifera Ehrhart fruit polysaccharide (PCP) was obtained after determining the optimal extraction conditions for complex enzyme-assisted hot buffer extraction based on single-factor experiments and response surface methodology, followed by characterization of its physicochemical, processing, rheological, and biological properties. PCP was a thermally stable carbohydrate with acidic functional groups and a molecular weight of 1398.69 kDa, exhibiting smooth, dense flake and honeycomb network microstructures.

The impact of Tanreqing injection on mucus hypersecretion and cough in bronchiectasis: A meta-analysis of randomized controlled trials.

Background: Bronchiectasis clinically manifests airway mucus hypersecretion as mucopurulent sputum production and chronic cough. In the past decade, Tanreqing injection (TRQ) has been often used in clinical practice as an add-on treatment for bronchiectasis in China. Several in vivo studies have indicated that TRQ is effective in improving sputum expectoration and cough in acute exacerbation of bronchiectasis but results of individual studies are inconsistent.

Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren's syndrome via suppression of the CX3CL1/CX3CR1 axis.

Introduction: Primary Sjögren syndrome (pSS) is a systemic autoimmune disease that is characterized by the infiltration of immune cells into the salivary glands. The re-establishment of salivary glands (SGs) function in pSS remains a clinical challenge. Myeloid-derived growth factor (MYDGF) has anti-inflammatory, immunomodulatory, and tissue-functional restorative abilities.

Effect of hydroxychloroquine on pregnancy outcome in patients with SLE: a systematic review and meta-analysis.

Objective: Hydroxychloroquine (HCQ) is an antimalarial drug employed in the treatment of systemic lupus erythematosus (SLE). Prior studies reported inconsistent results regarding the association between HCQ use during pregnancy and adverse pregnancy outcomes. This study aimed to evaluate the impact of HCQ on pregnancy-related outcomes in women with SLE.

Positive association between constipation and mild cognitive impairment in elders: A cross-sectional study.

This study aimed to examine the association between constipation and mild cognitive impairment (MCI); and further elucidate the possible mechanisms involved. A cross-sectional study was conducted among community-dwelling elders (N = 789) in Nanning, China. Trained research staffs collected detailed information through questionnaires and physical examinations.

Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates.

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 facilitate mitophagy by recruiting the autophagy-initiation machinery, and assisting engulfment of damaged mitochondria through binding to ubiquitinated mitochondrial proteins and autophagosomal ATG8 family proteins. Here, we demonstrate that OPTN and NDP52 form sheet-like phase-separated condensates with liquid-like properties on the surface of ubiquitinated mitochondria.