Publications by authors named "Zi Yan"

Myocardial hypertrophy (MH) is an important factor contributing to severe cardiovascular disease. Previous studies have demonstrated that specific deletion of the protein arginine methyltransferase 1 (PRMT1) leads to MH, but the exact mechanism remains unclear. Serine/arginine-rich splicing factor 1 (SRSF1) affects the development and progression of cardiovascular disease by selectively splicing downstream signaling proteins.

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  • Powdery mildew (PM) is a significant threat to wheat quality and yield, prompting a study on 262 recombinant inbred lines (RILs) from the Doumai and Shi 4185 wheat cross to identify PM resistance genes.
  • The research identified four stable quantitative trait loci (QTLs) associated with PM resistance, with Doumai contributing resistance alleles and several of these loci being potentially novel.
  • Additionally, three KASP markers were developed for efficient tracking of these QTLs, which could aid in improving wheat breeding strategies targeting PM resistance.
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Tea standard samples are the benchmark for tea product quality control. Understanding the inherent differences in Chinese national standards for Lapsang Souchong black tea of different grades is crucial for the scientific development of tea standardization work. In this study, Lapsang Souchong black tea of different grades that meet Chinese national standards was selected as the research object.

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Cerebral ischemia-reperfusion injury (IRI), occurring after blood supply restoration, contributes significantly to stroke-related deaths. This study explored the combined impact and mechanisms of astragaloside IV (AS-IV), hydroxysafflor yellow A (HSYA), and their combination in mitigating IRI. Male Sprague-Dawley (SD) rats were randomized to the Sham, MCAO, MCAO+AS-IV, MCAO+HSYA, and MCAO+AS-IV+HSYA groups.

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Unlabelled: Osteoarthritis (OA) is a common degenerative disease that affects millions of individuals worldwide.

Objective: There is no conclusive epidemiological evidence regarding the relationship between OA, depression, and whole-body fat mass. In this study, we conducted a two-step Mendelian randomization analysis to determine the causal relationships between them.

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Stroke episodes represent a significant subset of cerebrovascular diseases globally, often resulting in diverse neurological impairments such as hemiparesis, spasticity, dysphagia, sensory dysfunction, cognitive impairment, depression, aphasia, and other sequelae. These dysfunctions markedly diminish patients' quality of life and impose substantial burdens on their families and society. Consequently, the restoration of neurological function post-stroke remains a primary objective of clinical treatment.

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  • * Researchers successfully created memory-memory entanglement using three memory nodes over a distance of 12.5 kilometers, utilizing atomic ensemble quantum memory and a photonic server for photon detection.
  • * The project includes stabilizing phase variance in fiber links and demonstrates efficient entanglement generation, setting the stage for further testing and development of multi-node quantum network protocols.
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To effectively treat osteoarthritis (OA), the existing inflammation must be reduced before the cartilage damage can be repaired; this cannot be achieved with a single type of extracellular vesicles (EVs). Here, a hydrogel complex with logic-gates function is proposed that can spatiotemporally controlled release two types of EVs: interleukin 10 (IL-10) EVs to promote M2 polarization of macrophage, and SRY-box transcription factor 9 (SOX9) EVs to increase cartilage matrix synthesis. Following dose-of-action screening, the dual EVs are loaded into a matrix metalloporoteinase 13 (MMP13)-sensitive self-assembled peptide hydrogel (KM13E) and polyethylene glycol diacrylate/gelatin methacryloyl-hydrogel microspheres (PGE), respectively.

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  • - Cultured reticulocytes derived from induced pluripotent stem cells (iPSC) hold potential for transfusions, drug delivery, and immune therapy, but traditional production methods are costly and time-consuming.
  • - To improve efficiency, researchers created iPSC with specific genetic modifications (SCF receptor and jak2) that allow for the development of self-renewing erythroblasts, enabling cost-effective growth in a simple medium.
  • - These modified stem cells can produce cultured reticulocytes that are safe for transfusions, as they can be irradiated to remove any remaining nucleated cells, and they possess the required blood type characteristics to meet global demand.
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Tumor cells with damaged mitochondria undergo metabolic reprogramming, but gene therapy targeting mitochondria has not been comprehensively reported. In this study, plasmids targeting the normal hepatocyte cell line (L-O2) and hepatocellular carcinoma cell line were generated using three genes SIRT3, SIRT4, and SIRT5. These deacetylases play a variety of regulatory roles in cancer and are related to mitochondrial function.

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Unlabelled: Powdery mildew, caused by f. sp. (), is a severe disease that affects the yield and quality of wheat.

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  • * Data was collected from 601 Chinese adult child caregivers in 2021 using various instruments to measure caregiver burden, positive experiences, caregiving tasks, and levels of AFP.
  • * Findings indicate that higher caregiver self-efficacy helps turn caregiver burden into positive experiences, while AFP influences the relationship between caregiver burden and self-efficacy, suggesting the need for culturally aware support strategies.
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  • - The study investigates how an 8-week peer health coaching program enhances cultural competence (CC) among future health professionals, focusing on both student coaches and their clients.
  • - Results indicated a measurable increase in clients' perceptions of their coaches' cultural competence from pre- to post-intervention, highlighting the effectiveness of the program.
  • - Qualitative feedback identified three key themes: differing awareness levels, the importance of respectful and culturally responsive coaching, and fostering cultural connections during the coaching process.
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  • * Significant findings included loss of cortical surface area in key brain regions and decreases in white matter volume; interestingly, some areas showed increased thickness that correlated with better functional scores.
  • * The results suggest that both type II and III SMA in children exhibit extensive brain alterations that may relate to muscle deterioration, possibly influenced by the absence of the SMN protein affecting cerebellar and sensory brain regions.
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(1) Background: Diabetic cardiomyopathy (DCM) is a unique form of cardiomyopathy that develops as a consequence of diabetes and significantly contributes to heart failure in patients. Esaxerenone, a selective non-steroidal mineralocorticoid receptor antagonist, has demonstrated potential in reducing the incidence of cardiovascular and renal events in individuals with chronic kidney and diabetes disease. However, the exact protective effects of esaxerenone in the context of DCM are still unclear.

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Cardiomyocyte apoptosis is an important cause of trauma-induced secondary cardiac injury (TISCI), in which the endoplasmic reticulum stress (ERS)-mediated apoptosis signaling pathway is known to be first activated, but the mechanism remains unclear. In this study, rat models of traumatic injury are established by using the Noble-Collip trauma device. The expression of glucose-regulating protein 78 (GRP78, a molecular chaperone of the cardiomyocyte ER), acetylation modification of GRP78 and apoptosis of cardiomyocytes are determined.

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  • * Synaptotagmin-7 (Syt7) is significantly upregulated in heart cells affected by Ang II and contributes to cardiac hypertrophy by inhibiting autophagy.
  • * MicroRNA (miR)-93 is involved in regulating Syt7 expression, showing protective effects against hypertrophy and suggesting a potential therapeutic pathway involving miR-93, Syt7, and autophagy in heart disease treatment.
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The infections associated with implantable medical devices can greatly affect the therapeutic effect and impose a heavy financial burden. Therefore, it is of great significance to develop antimicrobial biomaterials for the prevention and mitigation of healthcare-associated infections. Here, a facile construction of antimicrobial surface via one-step co-deposition of peptide polymer and dopamine is reported.

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Evaluation of myelin content is crucial for attention-deficit/hyperactivity disorder (ADHD). To estimate myelin content in ADHD based on synthetic MRI-based method and compare it with established diffusion tensor imaging (DTI) method. Fifth-nine ADHD and fifty typically developing (TD) children were recruited.

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During the rice quality testing process, the precise segmentation and extraction of grain pixels is a key technique for accurately determining the quality of each seed. Due to the similar physical characteristics, small particles and dense distributions of rice seeds, properly analysing rice is a difficult problem in the field of target segmentation. In this paper, a network called SY-net, which consists of a feature extractor module, a feature pyramid fusion module, a prediction head module and a prototype mask generation module, is proposed for rice seed instance segmentation.

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  • - This study investigates the effects of Human Amnion-Derived Multipotent Progenitor (AMP) cells and their secretome ST266 on preventing neointimal hyperplasia (thickening of the arterial wall) after an injury in rats.
  • - Male Sprague-Dawley rats were divided into four groups and treated with either a control solution, ST266, systemic AMP cells, or local AMP implants after an induced arterial injury; histological analysis was performed after 28 days.
  • - Results showed that both ST266 and AMP cells significantly reduced neointimal formation and improved re-endothelialization, suggesting that ST266 could be a promising treatment for vascular injuries.
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The detection of traffic signs is easily affected by changes in the weather, partial occlusion, and light intensity, which increases the number of potential safety hazards in practical applications of autonomous driving. To address this issue, a new traffic sign dataset, namely the enhanced Tsinghua-Tencent 100K (TT100K) dataset, was constructed, which includes the number of difficult samples generated using various data augmentation strategies such as fog, snow, noise, occlusion, and blur. Meanwhile, a small traffic sign detection network for complex environments based on the framework of YOLOv5 (STC-YOLO) was constructed to be suitable for complex scenes.

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The coupling between resting-state cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) signals reflects the mechanism of neurovascular coupling (NVC), which have not been illustrated in attention-deficit/hyperactivity disorder (ADHD). Fifty ADHD and 42 age- and gender-matched typically developing controls (TDs) were enrolled. The NVC imaging metrics were investigated by exploring the Pearson correlation coefficients between CBF and BOLD-derived quantitative maps (ALFF, fALFF, DCP maps).

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