Publications by authors named "Zi Xiang Wu"
Background: Unplanned reoperation postspinal surgery (URPS) leads to prolonged hospital stays, higher costs, decreased patient satisfaction, and adversely affects postoperative rehabilitation. This study aimed to develop and validate prediction models (nomograms) for early URPS risk factors using machine learning methods, aiding spine surgeons in designing prevention strategies, promoting early recovery, reducing complications, and improving patient satisfaction.
Methods: Medical records of 639 patients who underwent reoperation postspinal surgery from the First Affiliated Hospital of Air Force Medical University (2018-2022) were collected, including baseline indicators, perioperative indicators, and laboratory indicators.
Article Synopsis
- Cervical spine fractures often lead to severe spinal cord injuries, which carry a high risk of death, particularly in the first year after the injury. Understanding mortality rates can aid in decision-making for patients and families.
- The study included 450 patients and revealed that surgical treatment lowers the immediate death risk, especially when performed early. Survival rates improved from 73.3% at baseline to 88.0% after two years.
- Conditional nomograms were developed to predict survival probabilities at various milestones (baseline, 6 months, and 12 months), showing strong performance in forecasting outcomes for patients post-injury.
Article Synopsis
- Polymethyl methacrylate (PMMA) bone cement is widely used in orthopedic surgery but has limitations like shrinkage, heat injury, and low bioactivity.
- Researchers developed a new material, expandable P(MMA-AA-St), which reduces shrinkage but lacks strong biomechanical properties, leading to the addition of graphene oxide (GO) for improvement.
- The modified composite, PGBCs, showed enhanced strength, water absorption, and cell compatibility, with better outcomes in rabbit bone defect studies, indicating its potential as an effective biomaterial for implants.
Closing-opening wedge osteotomy for the treatment of congenital kyphosis in children.
J Orthop Surg (Hong Kong)
September 2022
Background: To evaluate the safety and effectiveness of posterior closed-open wedge osteotomy for treatment of congenital kyphosis in children.
Methods: Imaging and clinical data from January 2010 to December 2019 of posterior closed-open wedge osteotomy of congenital kyphosis with at least 2-year follow up was analyzed retrospectively. Perioperative indicators such as operation time, osteotomy site, osteotomy method and occurrence of complications, and imaging indicators were observed.
Revision surgery (RS) is a necessary surgical intervention in clinical practice to treat spinal instrumentation-related symptomatic complications. Three constructs with different configurations have been applied in RS. One distinguishing characteristic of these configurations is that the revision rods connecting previous segments and revision segments are placed alongside, outside, or inside the previous rods at the level of facetectomy.
View Article and Find Full Text PDFObjective: This study aimed to retrospectively analyze clinical data of a series of patients with severe open fractures of extremities (Gustilo IIIb or IIIc), who achieved a satisfactory outcome through radical orthoplastic surgery, so as to provide a reference for determining the treatment of severe open fractures of extremities.
Methods: The clinical data of 41 consecutive patients with severe open fracture (Gustilo IIIb or IIIc) of the limb, who underwent successful surgical debridement, fixation, and soft tissue reconstruction in one stage between January 2008 and January 2019, were retrospectively reviewed. Postoperative indicators, including infection rate and union time, were acquired by a regular follow-up and analyzed.
Article Synopsis
- This study compared different surgical constructs for revision surgery on adjacent segment disease, focusing on how each method affects spinal stability and pressure on intervertebral discs.
- A finite element model was used to analyze four different constructs after primary surgery, looking at factors like range of motion and stress distribution.
- Results showed that implant-preserving methods gave similar biomechanical outcomes as traditional implant-replacing methods, with one construct (Construct B) suggested as the best option for being less invasive and easier to handle.
Spinal instrumented rod migrating from the surgical site to another remote site in the body is rare. Some cases result in organ or blood vessel injury. Most reported cases were asymptomatic until the finally injuries were generated.
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- The study evaluated a new connector rod's mechanical properties for preserving implants during revision surgery for adjacent segment disease, compared to traditional rod constructs that replace implants.
- Results showed that the connector rod performed similarly mechanically but resulted in significantly less surgical time and blood loss, with a lower infection rate compared to the traditional method.
- The connector rod led to better early postoperative results in pain and disability scores, confirming its safety and potential for reducing surgical trauma and costs.
Article Synopsis
- The study examines the link between type 1 diabetes (T1DM) and impaired bone formation, particularly focusing on how type H blood vessels in the bone contribute to this issue.
- T1DM induced in mice showed that abnormalities in bone blood vessels led to reduced bone formation and deterioration of bone quality, with higher blood sugar levels correlating to worse outcomes.
- Treatments with insulin, antioxidants, and NOX inhibitors showed potential in improving bone health in diabetic mice, suggesting that targeting oxidative stress in bone blood vessels could be a valuable therapeutic approach for T1DM-related bone issues.*
Cangrelor alleviates pulmonary fibrosis by inhibiting GPR17-mediated inflammation in mice.
Int Immunopharmacol
September 2018
Pulmonary fibrosis is a progressive and intractable lung disease. Macrophages play a critical role in the progression of pulmonary fibrosis. Cangrelor, an anti-platelet agent, is also a non-selective Gprotein-coupled receptor 17 (GPR17) antagonist.
View Article and Find Full Text PDFUnlabelled: Diabetes-induced reactive oxygen species (ROS) overproduction would result in compromised osteointegration of titanium implant (TI) and high rate of implant failure, yet the underlying mechanisms remain elusive. Adiponectin (APN) is a fat-derived adipocytokine with strong antioxidant, mitochondrial-protective and anti-diabetic efficacies. We hypothesized that mitochondrial dysfunction under diabetes may account for the oxidative stress in osteoblasts and titanium-bone interface (TBI) instability, which could be ameliorated by APN.
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- Scientists found tiny molecules called miRNAs in a virus that affects chickens called Gallid alphaherpesvirus 2 (GaHV2), which can cause cancer in these birds.
- GaHV2 has 26 miRNAs from 14 different parts, and some miRNAs help the virus make chickens sick while others might help to protect them.
- When researchers changed the Mid-cluster of miRNAs, they discovered that some miRNAs made the virus more harmful, but one specific miRNA helped decrease the sickness in infected chickens.
With the development of technology and space exploration, studies on long-duration space flights have shown that microgravity induces damage to multiple organs, including the dorsal root ganglia (DRG). However, very little is known about the effects of long-term microgravity on DRG neurons. This study investigated the effects of microgravity on lumbar 5 (L5) DRG neurons in rats using the hindlimb unweighting (HU) model.
View Article and Find Full Text PDFDystrophic scoliosis in neurofibromatosis type 1 (NF-1) is difficult to treat. The purpose of this study was to review the clinical and radiological outcome of surgical treatment of dystrophic spinal curves in NF-1, for analyzing its efficacy, safety, and possible complications.This retrospective study consisted of 26 NF-1 patients with spinal deformities treated between 2003 and 2012 in our department.
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- The study aimed to find the best amount of polymethylmethacrylate (PMMA) to use for enhancing a new type of fenestrated pedicle screw (FPS) designed for osteoporotic vertebrae and how PMMA distribution impacts screw strength.
- Two FPS designs were tested, one with equal diameter perforations and another with tapered perforations, across 28 human cadaver vertebrae, evaluating factors like cement distribution and pullout strength.
- Results showed that while increasing PMMA volume improved strength and altered cement distribution, the tapered design led to better PMMA anchoring and a lower risk of leakage, especially at higher volumes.
Article Synopsis
- The study investigates the effects of ovariectomy (OVX) on the structural components of cortical bone, focusing on changes in mineral and collagen over time in rabbits.
- It highlights that with increasing time post-OVX, the balance of mineral-to-matrix decreased while collagen crosslinking and crystallinity increased, leading to reduced bone strength at both tissue and whole-bone levels.
- The findings suggest that tracking these changes can inform better treatment strategies for osteoporosis by identifying critical periods for intervention.
Article Synopsis
- The study evaluated a new total cervical prosthesis (TCP) designed for single-level cervical subtotal corpectomy in a model using 12 adult Shannxi goats.
- The research aimed to assess both the radiologic and histological characteristics of the TCP, which offers a viable alternative to existing cervical disk replacements that are not suitable for subtotal corpectomy procedures.
- Results indicated successful implantation with no complications, preservation of motion in nearby vertebral segments, and positive signs of bone integration with the prosthesis, showing potential for effective stability after surgery.
Study Design: In this study, calcium sulfate (CS) was injected through pedicle into the osteoporotic vertebral body in vivo in sheep, and micro-computed tomography analysis, histologic observation, and biomechanical test were performed.
Objective: To investigate the improvement on microstructure and biomechanical performance of lumbar vertebrae augmented with CS in osteoporotic sheep.
Summary Of Background Data: The present treatments for osteoporosis relies on systemic medications intended to increase the bone mineral density (BMD).
Article Synopsis
- The study focuses on the pullout force of pedicle screws in bone and explores the stress distribution in the surrounding cancellous bone, which has been less studied compared to the screws themselves.
- Experiments and finite element simulations were conducted using two types of foam and then applied to different bone material properties representing three age groups to measure stress distribution and region of effect (RoE) around the screws.
- Results showed that the strength and load-displacement responses were consistent across simulations and experiments, with the RoE size (radius and volume) varying based on age-related bone characteristics, which could inform cement injection strategies in spine surgeries for osteoporosis patients.
Background: The surgical management of developmental dysplasia of the hip (DDH) in older children has been the subject of controversy. The purpose of this study was to evaluate the outcome in patients with neglected DDH who underwent individual procedures based on using three-dimensional computed tomography.
Methods: Forty-seven patients (59 hips) were treated using Pemberton osteotomy or Dega plus Pemberton osteotomy.
Article Synopsis
- * In an experiment with 96 male BALB/c mice, telmisartan was tested for its effect on femur fracture healing over periods of 2, 5, and 10 weeks using various analysis methods including X-ray and biomechanical testing.
- * Results revealed that telmisartan significantly enhanced callus formation, bone strength, and improved the microstructure of the healing bone, likely through increased cell proliferation and blood vessel formation.
The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats.
Evid Based Complement Alternat Med
October 2013
The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100 mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner.
View Article and Find Full Text PDFTi2448 pedicle screw system augmentation for posterior lumbar interbody fusion.
Spine (Phila Pa 1976)
November 2013
Article Synopsis
- A finite element analysis was conducted to assess the effectiveness of the Ti-24Nb-4Zr-7.9Sn (Ti2448) pedicle screw system in enhancing single-level posterior lumbar interbody fusion (PLIF).
- The Ti2448 system showed decreased axial displacement at the fusion level compared to both screw-free status and the Ti-6Al-4V system, indicating potential benefits in maintaining spinal stability.
- The study concluded that the Ti2448 screw system could reduce intradiscal pressures at adjacent discs, suggesting it may mitigate complications associated with traditional pedicle screw systems.
Introduction: The movements of the cervical spine during head rotation are too complicated to measure using conventional radiography or computed tomography (CT) techniques. In this study, we measure three-dimensional segmental motion of cervical spine rotation in vivo using a non-invasive measurement technique.
Material And Methods: Sixteen healthy volunteers underwent three-dimensional CT of the cervical spine during head rotation.