Publications by authors named "Zi Han Wang"

Article Synopsis
  • A study was conducted to investigate the ecological effects of different concentrations of traditional microplastics (polystyrene) and biodegradable microplastics (polylactic acid) in soil over 60 days, focusing on microbial activity and carbon metabolism.
  • Results showed that microplastics decreased soil pH and increased dissolved organic carbon, with polylactic acid significantly enhancing urease activity while polystyrene did not.
  • Higher concentrations of both types of microplastics inhibited microbial carbon metabolism, with polylactic acid having a more significant negative impact than polystyrene due to its tendency to degrade into harmful substances.
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  • - The study investigated how different durations of a cognitive-motor training program impact cognitive function in older adults with amnestic mild cognitive impairment (aMCI) in China, involving 72 participants from a nursing home.
  • - Results showed significant improvements in global cognition, visuospatial ability, and executive function after both 12 and 24 weeks of training, although attention did not show improvements after 12 weeks.
  • - The findings indicate that longer multi-domain cognitive-motor training can enhance cognitive functions, especially in attention and executive function for older adults with aMCI.
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  • Prussian blue analogs (PBAs) show potential as cost-effective cathode materials for sodium-ion batteries due to their easy synthesis and high capacity, but they struggle with issues like poor electrical conductivity and phase transitions affecting performance.
  • This study presents a method to enhance the performance of cobalt-free PBAs by reducing crystalline water content and improving conductivity through high-entropy and stoichiometry adjustments.
  • The optimized compound, FeMn-HCF, achieves impressive results: 100% initial Coulombic efficiency, a specific capacity of 115 mAh/g at low current, and strong cycling stability with substantial capacity retention after extensive use.
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Background: Spontaneous thought is a universal, complex, and heterogeneous cognitive activity that significantly impacts mental activity and strongly correlates with mental disorders.

Methods: Utilizing the think-aloud method, we captured spontaneous thoughts during rest from 38 diagnosed with depression, alongside 36 healthy controls and 137 healthy individuals. Through a comprehensive assessment of various dimensions of thought content, we compared thought content between individuals with depression and healthy controls, and between healthy women and men.

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Previous studies in small samples have identified inconsistent cortical abnormalities in major depressive disorder (MDD). Despite genetic influences on MDD and the brain, it is unclear how genetic risk for MDD is translated into spatially patterned cortical vulnerability. Here, we initially examined voxel-wise differences in cortical function and structure using the largest multi-modal MRI data from 1660 MDD patients and 1341 controls.

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Diabetic nephropathy (DN) is a common and serious complication of diabetes, contributing significantly to patient mortality. Complication of DN (CDN) ranks as the second leading cause of end-stage renal disease globally. To address this, understanding the genetic regulation underlying DN is crucial for personalized treatment strategies.

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Chiral coumarins and their derivatives are ubiquitous structural motifs found in an array of biologically and therapeutically active natural products and drugs. Herein, a highly enantioselective dual remote copper-catalyzed vinylogous alkynylallylic substitution of yne-allylic esters with coumarins has been developed. The practicality of this method is exemplified by the use of readily available starting materials; mild reaction conditions; excellent regio-, enantio-, and stereoselectivities; and the very broad substrate scope (67 examples), while the scalability and further applications of this method are illustrated by the gram-scale reaction and the series of derivations of the products.

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Ischemic stroke is one of the most disabling and fatal diseases around the world. The damaged brain tissues will undergo excessive autophagy, vascular endothelial cells injury, blood-brain barrier (BBB) impairment and neuroinflammation after ischemic stroke. However, there is no unified viewpoint on the underlying mechanism of brain damage.

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Ovarian aging is a complex process characterized by a decline in oocyte quantity and quality, directly impacting fertility and overall well-being. Recent researches have identified mitochondria as pivotal players in the aging of ovaries, influencing various hallmarks and pathways governing this intricate process. In this review, we discuss the multifaceted role of mitochondria in determining ovarian fate, and outline the pivotal mechanisms through which mitochondria contribute to ovarian aging.

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Although GaN is a promising candidate for semiconductor devices, degradation of GaN-based device performance may occur when the device is bombarded by high-energy charged particles during its application in aerospace, astronomy, and nuclear-related areas. It is thus of great significance to explore the influence of irradiation on the microstructure and electronic properties of GaN and to reveal the internal relationship between the damage mechanisms and physical characteristics. Using a combined density functional theory (DFT) and molecular dynamics (AIMD) study, we explored the low-energy recoil events in GaN and the effects of point defects on GaN.

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Objective: SET domain-containing protein 1A (SETD1A) histone lysine N-methyltransferase may serve as a biomarker for the auxiliary diagnosis and treatment assessment of schizophrenia (SCZ). The aim of this study was to compare serum levels of SETD1A protein between patients with SCZ and health controls.

Methods: Patients with SCZ and health controls were recruited from the Sixth Hospital of Changchun and the 'Survey on Chronic Diseases and Risk Factors among Adults in Jilin Province', respectively.

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Soil microbiome is a key evaluation index of soil health. Previous studies have shown that organic fertilizer from traditional Chinese medicine(TCM)residues can improve the yield and quality of cultivated traditional Chinese medicinal materials. However, there are few reports on the effects of organic fertilizer from TCM residues on soil microbiome.

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This paper reports the isolation of two undescribed phenolic glycosides ( and ), together with seven known compounds (-) from the branches of . The structures of undescribed compounds were elucidated by comprehensive spectroscopic methods (1D NMR, 2D NMR, and HRESIMS). The sugar units of compounds and were identified by acid hydrolysis and HPLC analysis of the chiral derivatives of the monosaccharides.

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It is well-known that highly reactive hydroxyl radicals (HO) can be produced by the classic Fenton system and our recently discovered haloquinone/HO system, but rarely from thiol-derivatives. Here, we found, unexpectedly, that HO can be generated from HO and thiourea dioxide (TUO), a widely used and environmentally friendly bleaching agent. A carbon-centered radical and sulfite were detected and identified as the transient intermediates, and urea and sulfate as the final products, with the complementary application of electron spin-trapping, oxygen-18 isotope labeling coupled with HPLC/MS analysis.

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Background: Early-onset androgenetic alopecia (AGA) has been associated with various chronic conditions, including metabolic syndrome (MetS). Gaining a deep understanding of early-onset AGA may enable earlier intervention in individuals at high risks. This scoping review aims to explore the risk factors and etiology, associated conditions, and adverse effects on wellbeing in early-onset AGA.

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We have found recently that two-step intrinsic hydroxyl radical (OH)-dependent chemiluminescence (CL) could be produced by carcinogenic tetrahaloquinone and HO. However, the first-step CL was too fast to clearly detect the stepwise generation of OH and CL, and to distinguish the exact dividing point between the first-step and second-step CL. Here we found that, extremely clear two-step intrinsic CL could be produced by the relative slow reaction of tetrabromohydroquinone (TBHQ) with HO, which was directly dependent on the two-step OH generation.

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Purpose: PAFAH1B1, also known as LIS1, is associated with type I lissencephaly in humans, which is a severe developmental brain disorder believed to result from abnormal neuronal migration. Our objective was to characterize the genotypes and phenotypes of PAFAH1B1-related epilepsy.

Methods: We conducted a comprehensive analysis of the medical histories, magnetic resonance imaging findings, and video-electroencephalogram recordings of 11 patients with PAFAH1B1 variants at the Neurology Department of Beijing Children's Hospital from June 2017 to November 2022.

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Article Synopsis
  • - Moutan Cortex (MC) residues, usually disposed of as waste, can be re-extracted for beneficial compounds and converted into organic fertilizer and animal feed, reducing environmental pollution.
  • - Analysis showed that MC residues contain lower levels of active chemicals compared to the original material, with key compounds reduced further after composting.
  • - The compost derived from MC residues demonstrated a significant increase in essential nutrients, indicating it can serve as a high-quality organic fertilizer ideal for cultivating Chinese medicinal herbs.
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The conversion of carbon dioxide (CO) from biogas into medium-chain fatty acids (MCFAs) represents an eco-friendly resource recovery approach to reduce dependence on fossil fuels and combat global climate change. This study presented the novel concept of integrated resource recovery by coupling biogas upgrading and MCFAs production for the first time. Initially, the impact of different initial ethanol concentrations on chain elongation was examined, determining that an ethanol concentration of 160 mmol/L maximized MCFAs yield at 45.

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The pursuit of food-based alternatives to conventional therapies for ulcerative colitis (UC) demands immediate attention. In prior investigations, we synthesized WPI-stachyose conjugates through the Maillard reaction, identifying them as functional prebiotics. However, their impact on regulation of gut microbiota remains inadequately explored.

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Utilizing H-assisted ex-situ biogas upgrading and acetate recovery holds great promise for achieving high value utilization of biogas. However, it faces a significant challenge due to acetate's high solubility and limited economic value. To address this challenge, we propose an innovative strategy for simultaneous upgrading of biogas and the production of medium-chain fatty acids (MCFAs).

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Background: Breast cancer is the most common malignancy in female patients. In recent years, more and more studies have focused on how to improve the appearance and the quality of life for patients. This study aimed to compare the oncologic safety, aesthetic results, and upper extremity function between single-port insufflation endoscopic nipple-sparing mastectomy (SIE-NSM) and conventional open mastectomy (C-OM) in early-stage breast cancer treatment.

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Impressive progress has been made in the copper-catalyzed asymmetric propargylic substitution (APS) reaction, but its use in remote asymmetric yne-allylic substitution remains a challenging topic. Herein, we report the first remote enantioselective copper-catalyzed sulfonylation of yne-allylic esters with sodium sulfinates. The reaction is assumed to occur via a copper-vinylvinylidene species as the key reactive intermediate.

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