Albumin Corona-Coated Nanoscale Metal-Organic Framework for Enzyme-Mediated Cascade Metabolization of Uric Acid in Hyperuricemia.

Hyperuricemia, characterized by elevated uric acid levels, is the primary cause of gout. Recombinant uricase is one of the last-resort therapies but generates unwanted pro-inflammatory HO and anti-uricase antibodies. In this work, we developed an albumin corona-coated enzyme-loaded zeolitic imidazolate framework (UCZIF) to sustainably maintain low blood uric acid level without producing HO.

Abnormal Slow Phonon Dynamics Toward Prolonging Excited States Dynamics Enabled by Crystalline-Assembling Donor-Acceptor Molecules.

Phonon dynamics are a critical factor to control the optical properties of excited states in light-emitting materials. Here, we report an extremely slow relaxation of photoexcited lattice vibrations enabled by assembling the donor-acceptor (D-A) molecules [2-(9,9-dimethylacridin-10(9H)-yl)-9,9-dimethyl-9H-thioxanthene 10,10-dioxide], namely AC molecules, into dipolar crystal. By using photoexcitation-modulated Raman spectroscopy, we find that the crystalline-lattice vibrations monitored by Raman-scattering laser beam of 785 nm demonstrate an un-usual slow relaxation in the time scale of seconds after ceasing photoexcitation beam of 343 nm in such dipolar crystal.

Polyhydroxy Sodium Salt Additive to Regulate Zn Solvation Structure and Zn Deposition Texture for High-Stability and Long-Life Aqueous Zinc Batteries.

Electrolyte additives are commonly employed in aqueous zinc-ion batteries (ZIBs) to suppress dendrite growth, corrosion, and hydrogen evolution. However, rational design principles and systematic mechanistic studies for selecting suitable additives to regulate reversible Zn plating/stripping chemistry are worth in-depth study. Using L-ascorbic acid sodium (LAAS) as the representative, theoretical calculations combined with in situ experimental analyses manifest that polyhydroxy-sodium-salts preferentially chemisorbed on Zn surface to construct the HO-poor interfacial microenvironment, suppressing undesirable water-related side reactions.

Feasibility exploration of myocardial blood flow synthesis from a simulated static myocardial computed tomography perfusion via a deep neural network.

Background:: Myocardial blood flow (MBF) provides important diagnostic information for myocardial ischemia. However, dynamic computed tomography perfusion (CTP) needed for MBF involves multiple exposures, leading to high radiation doses.

Objectives:: This study investigated synthesizing MBF from simulated static myocardial CTP to explore dose reduction potential, bypassing the traditional dynamic input function.

Effects of exercise on older adults with mild cognitive impairment: A systematic review and network meta-analysis.

Mild cognitive impairment (MCI) represents a transitional stage between normal aging and Alzheimer's disease (AD), with a significantly elevated risk of progressing to AD. In recent years, accumulating evidence has indicated that exercise interventions may mitigate cognitive decline in individuals with MCI and reduce the risk of conversion to AD, potentially through mechanisms such as enhancing cerebral blood flow and promoting neuroplasticity. To explore which type of exercise is most effective in improving global cognition in older adults with MCI and to investigate whether exercise can enhance their balance abilities.

Light-Driven Low-Temperature and Near-Unity Conversion of Ester on a Perovskite Derivative Photothermal Catalyst via Photon-Bismuth Triggered Hotspot.

Solar-driven photothermal chemical transformations are regarded as green processes to reduce energy consumption and are expected to utilize unique light-induced activation mechanisms to improve reaction kinetics. Halide perovskites and their derivatives, due to unique optoelectronic properties and compositional flexibility, are allowed for the precise regulation of energy band structures and surface electronic states, showing potentials as photoactivated catalysts with photo-thermal synergistic effects. However, the photothermal catalytic performance of halide perovskites is still unsatisfied with low conversion (<0.

Porous PtCu Alloys Decode Plasma Metabolic Fingerprints for the Recognition of Severe Community-Acquired Pneumonia.

Rapid and accurate recognition of severe community-acquired pneumonia (CAP) would facilitate the optimal intervention. Currently, the diagnosis of severe CAP is commonly based on the criteria established by Infectious Disease Society of America (IDSA)/American Thoracic Society (ATS), which include 2 primary and 9 secondary criteria, making the process cumbersome and time-consuming. Here, a porous PtCu alloy-assisted laser desorption/ionization mass spectrometry (LDI MS) is designed for the extraction of plasma metabolic fingerprints (PMFs), coupling with machine learning for the diagnosis of severe CAP.

Obesity is associated with progressive brain structural changes.

Objective: The aim of this study was to investigate the relationship between obesity (OB) progression and brain structural changes.

Methods: T1-weighted magnetic resonance images were acquired from 258 participants with overweight (OW) or OB and 74 participants with normal weight. Participants with OW or OB were divided into four groups according to BMI grades.

A Semi-Interpenetrating Network Hydrogel with Excellent Photothermal Antibacterial and ROS Scavenging Activities for MRSA-Infected Wounds.

The prolonged infection of bacteria at the wound site may lead to serious physical problems. Herein, a multifunctional macroporous hydrogel with superior photothermal antibacterial and ROS scavenging activity (denoted as M-XG gel) was designed for the treatment of MRSA-infected wounds. The M-XG gels are composed of embedding Prussian blue nanoparticles (PBNPs) as photothermal converters and chelating ferric ions with xanthan gum (XG) and dopamine (DA) to form a semipermeable network.

Elevated atherogenic index of plasma is associated with increased cardiorenal syndrome prevalence: a cross-sectional study.

Purpose: Cardiorenal syndrome (CRS) is a complex clinical condition characterized by the simultaneous dysfunction of the heart and kidneys. The atherogenic index of plasma (AIP), calculated as the logarithm of the ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C), has emerged as a potential biomarker for cardiovascular risk. This study investigates the association between AIP and CRS, aiming to explore the potential linkage between AIP and CRS.

Helmeted hornbill cranial kinesis: Balancing mobility and stability in a high-impact joint.

Prokinesis-in which a craniofacial joint allows the rostrum to move relative to the braincase-is thought to confer diverse advantages in birds, mostly for feeding. A craniofacial joint would, however, be a weak link if cranial stability is important. Paradoxically, we have identified a craniofacial joint in helmeted hornbills (Rhinoplax vigil), birds known for violent head-butting behavior.

SERS/Fluorescence Dual-Modal Imaging Bioprobe for Accurate Diagnosis of Breast Cancer.

Early diagnosis and precise identification of breast cancer subtypes are vital. However, current detection methods are often hindered by high costs and complexity. This study aims to develop an efficient and noninvasive method to realize efficient breast cancer detection.

Microneedles Loaded with Nitric-Oxide Driven Nanomotors Improve Force-Induced Efferocytosis Impairment and Sterile Inflammation by Revitalizing Macrophage Energy Metabolism.

Mechanical force initiates sterile inflammation, a process implicated in diverse physiological and pathological processes. The timely clearance of apoptotic cells by macrophages via efferocytosis is crucial for the proper resolution of sterile inflammation and for averting excessive tissue damage. Despite this, the specific role and underlying mechanisms of mechanical force on macrophage efferocytosis remain obscure.

Precision Self-assembly of 3D DNA Crystals Using Microfluidics.

Controlling the uniformity in size and quantity of macroscopic three-dimensional (3D) DNA crystals is essential for their integration into complex systems and broader applications. However, achieving such control remains a major challenge in DNA nanotechnology. Here, we present a novel strategy for synthesizing monodisperse 3D DNA single crystals using microfluidic double-emulsion droplets as nanoliter-scale microreactors.

Effects of Tai Chi on Multiple Brain Networks Structure-Function Couplings in Individuals with Subthreshold Depression: A Randomized Controlled Trial.

Introduction: Subthreshold depression represents a prodromal stage of major depressive disorder and may be associated with abnormalities in brain structural and functional networks. While studies have shown that mind-body exercises such as Tai Chi can alleviate subthreshold depression, the underlying mechanisms remain unclear. Purpose: This study aimed to explore the potential mechanisms of Tai Chi for improving subthreshold depression from the perspective of structure-function coupling of brain networks.

Tailored Metal-Phenolic Network with Hypoglycemic Polyphenol for Promoting Diabetic Wound Healing.

Diabetic foot ulcer is a common and serious complication of diabetes, with a high risk of amputation, recurrence, and mortality. Aiming at the characteristics of diabetic wounds and based on the result of network pharmacology, a tailored ligand cyanidin-3--glucoside (C3G) was selected to construct a metal-phenolic network (CM) through the self-assembly reaction with manganese ions. CM integrates the pharmacological advantages of C3G in antidiabetes and the anti-inflammatory activity of metal-phenolic networks by simulating the metal coordination structure of antioxidant enzymes.

2'-FL and cross-feeding bifidobacteria reshaped the gut microbiota of infants with atopic dermatitis ex vivo and prevented dermatitis in mice post-microbiota transplantation through retinol metabolism activation.

2'-Fucosyllactose (2'-FL), a predominant human milk oligosaccharide, plays a crucial role in the development of the infant gut microbiota and immune system. However, the microbiota of infants with atopic dermatitis (AD) often has difficulty utilizing 2'-FL. Here, we found that strains from human milk, FN120 and subsp.

Molecular mechanism of METTL3 regulating hippocampal neuronal injury induced by sepsis-associated encephalopathy.

Objective: This study explores the mechanism of methyltransferase like 3 (METTL3) on sepsis-associated encephalopathy (SAE)-induced hippocampal neuronal injury.

Methods: A murine model of SAE was established by caecal ligation and puncture. Hippocampal cells were induced by lipopolysaccharide (LPS).

A pathogenic NR2F1 gene variant disrupts transcriptional activity and causes severe neurodevelopmental delay in Bosch-Boonstra-Schaaf syndrome.

Introduction: Nuclear receptor subfamily 2, group F, member 1 (NR2F1) gene variations are associated with Bosch-Boonstra-Schaaf optic atrophy syndrome. The NR2F1 genotype correlates with its phenotype; variants within the DNA-binding domain may cause severe psychomotor developmental disorders. However, the mechanisms underlying these phenotypes remain unclear.

Identification of blood-derived exosomal tumor RNA signatures as noninvasive diagnostic biomarkers for multi-cancer: a multi-phase, multi-center study.

Background: Cancer remains a leading global cause of mortality, making early detection crucial for improving survival outcomes. The study aims to develop a machine learning-enabled blood-derived exosomal RNA profiling platform for multi-cancer detection and localization.

Methods: In this multi-phase, multi-center study, we analyzed RNA from exosomes derived from peripheral blood plasma in 818 participants across eight cancer types during the discovery phase.

Potential mechanism of circKIAA1429 accelerating the progression of hepatocellular carcinoma.

Background: This study investigates the underlying mechanism of circKIAA1429 (hsa_circ_0084922) in hepatocellular carcinoma (HCC) progression.

Methods: circKIAA1429, SETD1A, NAP1L3, and GLIS2 expressions in HCC cells were detected by RT-qPCR or western blot. The stability of circKIAA1429 was tested after treatment with actinomycin D and Rnase R enzyme.

Inhibition of circALPK2 enhances proliferation and therapeutic potential of human pluripotent stem cell-derived cardiomyocytes in myocardial infarction.

Background: Understanding the mechanisms regulating human cardiomyocyte proliferation holds significant promise for developing effective therapies to enhance cardiac regeneration and repair. This study investigates the role of circALPK2, a circular RNA derived from the back-splicing of the 4th exon of alpha protein kinase 2 (ALPK2), in regulating cardiomyocyte proliferation and its therapeutic efficacy in myocardial infarction (MI) treatment.

Methods: Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) were used to assess the expression and function ofcircALPK2.

Association between Capillaria hepatica infection-induced alterations in gut microbiota and estrogen expression in Brandt's voles (Lasiopodomys brandtii).

Background: Capillaria hepatica, a zoonotic parasite, is present in the population of Brandt's voles (Lasiopodomys brandtii) and has been a central issue in ecological studies regarding its impact on host populations. Brandt's voles are known for their extremely high reproductive capacity, and the population explosion of Brandt's voles have occurred multiple times in the grasslands of Inner Mongolia over the past few decades. However, the mechanisms underlying the population dynamics of Brandt's voles, particularly in response to C.

IRF1 is a core transcriptional regulatory circuitry member promoting AML progression by regulating lipid metabolism.

Background: Acute myeloid leukemia (AML) is a prevalent malignancy of the hematologic system. Despite advancements in therapeutic approaches, significant heterogeneity and therapeutic resistance pose substantial challenges to treatment. Tumors driven by core transcription factors through super-enhancers can establish core transcriptional regulatory circuits (CRCs) that modulate oncogene expression programs.

cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia.

Background: Impairment of the inner blood-retinal barrier (iBRB) leads to various blinding diseases including diabetic retinopathy (DR). The cGAS-STING pathway has emerged as a driving force of cardiovascular destruction, but its impact on the neurovascular system is unclear. Here, we show that cGAMP, the endogenous STING agonist, causes iBRB breakdown and retinal degeneration thorough P2RX7-mediated transport into microglia.