Comparison of the effects of taurine and methionine supplementation on the nitrogen metabolism of beef steers elucidated through plasma metabolome profiling.

The objectives of the experiment were to compare the effects of rumen-protected taurine (RPT) and rumen-protected methionine (RPM) on the nitrogen (N) metabolism, plasma biochemical parameters, and metabolomics in beef steers and to clarify whether taurine plays similar roles as methionine (Met) in the regulation of N metabolism in beef steers. Six Simmental steers aged 12 months (liveweight 325 ± 7 kg) were used as experimental animals. The experimental treatments included a basal diet, the basal diet + 70.

Polymer-modified DNA hydrogels for living mitochondria and nanozyme delivery in the treatment of rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to joint deformities and functional impairments. Traditional treatment approaches, such as nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, and molecular targeted therapies, often fail to simultaneously achieve efficient inflammation relief and cartilage tissue repair. DNA hydrogels, derived from nucleic acid nanotechnology, have demonstrated potential in RA therapy due to their programmability, high biocompatibility, and tunable degradation properties.

Bibliometric analysis of preoperative radiotherapy for locally advanced rectal cancer: evolution and future.

Background: Preoperative radiotherapy of rectal cancer has been a hot topic of research in recent years with the introduction of total neoadjuvant therapies and immunotherapeutic agents. We utilized bibliometrics and visualization analysis to examine studies in this field, aiming to identify current hotspots and research trends.

Method: We searched the Web of Science database for all publications related to preoperative radiotherapy of rectal cancer in the past 10 years.

Global, regional, and national burden of chronic kidney disease due to diabetes mellitus type 2 from 1990 to 2021, with projections to 2036: a systematic analysis for the Global Burden of Disease Study 2021.

Background: Chronic kidney disease (CKD) due to type 2 diabetes mellitus (T2DM) has emerged as a significant global health burden, with rising incidence and prevalence rates observed over the past decades.

Methods: We utilized the latest data from the Global Burden of Disease Study (GBD) 2021. Firstly, we reported the number of incidence, prevalence, deaths, and Disability-Adjusted Life Years (DALYs) attributed to CKD due to T2DM, accompanied by their respective Age-Standardized Rates (ASRs), for the year 2021.

Association between dementia, Alzheimer's disease, and liver cancer: A Mendelian randomization analysis.

Background: Epidemiological studies have indicated an inverse association between neurodegenerative diseases and cancer. However, the relationship between liver cancer and dementia, particularly Alzheimer's disease (AD), remains underexplored.

Objective: This study aimed to determine the association between dementia, specifically AD, and liver cancer using Mendelian randomization (MR) analysis.

Multidimensional comparative analysis of wild and cultivated based on electronic intelligent sensory technology and chemical composition.

, is a renowned traditional Chinese medicine, has been widely utilized in various pharmaceutical applications. The increasing demand for this material has led to the widespread cultivation of the plant. However, the differences in chemical constituents between wild and cultivated remain unclear.

Prediction of right recurrent laryngeal nerve lymph node metastasis in esophageal cancer based on computed tomography imaging histology.

Purpose: This study aimed to identify risk factors for right recurrent laryngeal nerve lymph node (RRLNLN) metastasis using computed tomography (CT) imaging histology and clinical data from patients with esophageal squamous cell carcinoma (ESCC), ultimately developing a clinical prediction model.

Methods: Data were collected from 370 patients who underwent surgical resection at the Department of Thoracic Surgery, Zhongshan Hospital of Xiamen University, from December 2014 to December 2020. Subsequently, the venous-stage chest-enhanced CT images of the patients were imported into 3DSlicer 4.

PROKR2 mutations and SPRY4 variants with uncertain significance in a Kallmann syndrome family: Incomplete penetrance.

Kallmann syndrome is a rare genetic disease characterized by the idiopathic hypogonadotropic hypogonadism with hyposmia or anosmia, which exhibits considerable heterogeneity in genotype and phenotype. Herein, we reported a 32-year-old male patient with Kallmann syndrome in a family associated with heterozygous mutations in PROKR2 and SPRY4 genes. The genotyping results indicated PROKR2 mutations and SPRY4 variants of uncertain significance, which might be incompletely penetrant in this family.

Impact of segmental body composition on metabolic fatty liver disease in Chinese children.

Purpose: This study aimed to assess the relationship between regional body composition and metabolic dysfunction-associated fatty liver disease (MAFLD) in Chinese children.

Methods: In this study, 1399 children aged 7-14 years were included. Liver steatosis was assessed using the controlled attenuation parameter (CAP) measured through Fibroscan.

A prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasis.

Background: Despite having negative lymph node (N0) status, thyroid cancer (TC) patients can still experience distant metastasis (DM), which significantly impacts their survival. This study aimed to investigate the prognostic factors for DM in TC patients (N0) and develop a predictive nomogram model for analyzing the prognosis of TC N0 patients with DM.

Methods: Data collected from the Surveillance, Epidemiology, and End Results (SEER) database for 18,504 TC patients (N0) between 2004 and 2015 were analyzed.

Correlation Between Monocyte Count, Monocyte-Lymphocyte Ratio, and Other Inflammatory Cells With Sleep and Psychiatric Symptoms in First-Episode Schizophrenia Patients.

Background: More and more evidence shows that infection and immune abnormality are closely related to the increased severity of schizophrenia symptoms. This study aimed to explore the correlation between inflammatory cell counts, sleep quality, and psychiatric symptoms in first-episode schizophrenia patients.

Methods: A total of 103 first-episode schizophrenia patients (patient group) admitted to the Anhui Provincial Mental Health Center from November 2021 to August 2022 were included in the study, while 57 healthy individuals (control group) who met the criteria were recruited as the study subjects.

Examining the prognostic and clinicopathological significance of GPX4 in human cancers: a meta-analysis.

Elevated levels of the enzyme GPX4 have been detected in tumor tissues, which may play a role in cancer progression. We did a meta-analysis of eight studies encompassing 1180 individuals to evaluate the importance of GPX4 in cancer, particularly in terms of prognosis and clinicopathological characteristics. Research results indicate that higher levels of GPX4 were linked to worse overall survival (OS) (HR = 1.

Transport of continental particulate over the Labrador Sea and entrainment are important pathways for glaciation of remote marine clouds.

Marine Arctic clouds greatly influence the radiative balance across the Arctic region and their effectiveness at scattering radiation changes considerably depending on cloud phase. Glaciation of these clouds relies on the presence of ice nucleating particles, which are often limited in number, so often clouds may be liquid even at temperatures well below 0 °C. As the Arctic region warms, cloud feedbacks may accelerate change or lessen absorbed solar radiation.

Cerium Dioxide Nanoparticles-Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy.

Imbalanced mitochondrial quality control is strongly linked to the onset and development of osteoarthritis (OA). However, current research primarily focuses on local cartilage repair and phenotype maintenance, lacking a systematic approach to subcellular mitochondrial quality control. To address this, the present study proposes a mitochondrial quality control strategy based on nanozyme hydrogel microspheres ("mitochondrial inspector"), constructed through electrostatic self-assembly, incorporation of dynamic diselenide bonds, and microfluidic technology.

High-Efficiency Continuous Spin-Conduction through NiO/Cu Bilayer Structure.

Materials that effectively separate charge and spin currents are key to advancing spin-orbit torque-based switching devices for nanomagnet memory. NiO, an insulating yet spin-conducting material, is essential in such systems. Interfacing NiO with a heavy metal like Pt, confines charge current to Pt while allowing spin current to pass through NiO into an adjacent NiFe layer.

Cis/Trans Isomeric Valence Tautomeric Compounds with Guest-Driven Conformational Adaptation in Pillar[5]arene Structures.

The pursuit of ancillary ligands is crucial for constructing new valence tautomeric (VT) complexes based on the dioxolene-cobalt(II/III) moiety. In this study, we adopted pillar[5]arene derivatives with guest-adaptable conformations─specifically, phenylpyridine-containing pillar[5]arene (pyphp[5]) and alkynylpyridine-containing pillar[5]arene (pyetp[5])─as ancillary and bridging ligands to synthesize a series of cobalt-based VT complexes: [Co(Sq)(Cat)(pyphp[5])]·2CHCl·2CHOH (), [Co(Sq)(Cat)(pyphp[5])]·4ClCHCHCl·2CHOH (), [Co(Sq)(Cat)(pyetp[5])]·2CHCl·3CHOH (), and [Co(Sq)(Cat)(pyetp[5])]·3ClCHCHCl·2CHOH () (Sq = 3,5-di--butylsemiquinonate, Cat = 3,5-di--butyl-catecholate). Single-crystal X-ray diffraction analyses revealed that all complexes possess one-dimensional structures.

Steroids combined with anticoagulant in acute/subacute severe cerebral venous thrombosis.

Background: Inflammation plays a critical role in severe cerebral venous thrombosis (CVT) pathogenesis, but the benefits of anti-inflammatory therapies remain unclear. This study aimed to investigate the association between steroid therapy combined with anticoagulation and the prognosis of acute/subacute severe CVT patients.

Methods: A prospective cohort study enrolled patients with acute/subacute severe CVT at Xuanwu Hospital (July 2020-January 2024).

Multimodal magnetic resonance imaging analysis of early mild cognitive impairment.

Background: Early mild cognitive impairment (EMCI) represents a prodromal stage of dementia, and early detection is crucial for delaying dementia progression. However, accurately identifying its neuroimaging features remains challenging.

Objective: To comprehensively evaluate structural and functional neuroimaging changes in EMCI using multimodal magnetic resonance imaging (MRI) techniques.

Detection of retinal nerve fiber layer in patients with high myopia complicated with glaucoma by optical coherence tomography.

Objective: To detect the changes in the thickness of the Retinal Nerve Fiber Layer (RNFL) in patients with High Myopia (HM) complicated with glaucoma through Optical Coherence Tomography (OCT).

Methods: 80 patients (160 eyes) with HM complicated with glaucoma treated from March 2018 to March 2020 were enrolled as the experimental group, and 60 healthy volunteers (120 eyes) undergoing physical examination in the same period were selected as the control group. OCT measured their RNFL thicknesses.

High-Efficiency Cell-Type Proteomics Strategy Deciphers Cholangiocarcinoma Fibrosis-Associated Pathological Heterogeneity.

Cholangiocarcinoma (CCA) is the second most common primary liver cancer and is characterized by huge heterogeneity, difficult diagnosis, and poor prognosis. Fibrosis-associated heterogeneity in CCA serves as an indicator of the malignant progression of cancer; however, a precise approach to deciphering fibrosis heterogeneity is still lacking. Typically, the tissue proteome is profiled by analyzing bulk tissues, which gives average results of different cell types, especially for CCA tissues in which cancer cells occupy a very small proportion.

[Regulation of JAK2/STAT3 signaling pathway by polydatin in the treatment of hormone-induced femoral head necrosis in rats].

Objective: To explore the therapeutic effect of polygonum cuspidatum glycoside on steroid-induced osteonecrosis of the femoral head(SONFH) in rats and its potential mechanism of protecting bone tissue by regulating the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway(JAK2/STAT3).

Methods: Fifty male SD rats were randomly divided into control group, model group, low-dose polygonum cuspidatum glycoside group (polygonum cuspidatum glycoside-L), high-dose polygonum cuspidatum glycoside group (polygonum cuspidatum glycoside-H), and polygonum cuspidatum glycoside-H+Colivelin (JAK2/STAT3 pathway activator) group. SONFH model was induced by lipopolysaccharide and dexamethasone.

[Comparison of side-opening and front-opening approach bone cement injectors in percutaneous kyphoplasty for thoracolumbar osteoporotic vertebral compression fractures].

Objective: To compare clinical efficacy between side-opening and front-opening bone cement injectors in percutaneous kyphoplasty(PKP) for the management of thoracolumbar osteoporotic vertebral compression fractures(OVCFs).

Methods: A retrospective cohort study was conducted, comprising 62 patients with single-segment thoracolumbar OVCFs (T-L), who underwent bilateral PKP at our department during the period from June 2020 to October 2021. Patients were categorized into two groups based on the specific bone cement injector employed during the surgical procedure: the side-opening group (=29) and the front-opening group (=33).

Ginsenoside Rg1 inhibits angiogenesis in diabetic retinopathy through the miR-100-3p/FBXW7/c-MYC molecular axis.

Aims/introduction: Ginsenoside Rg1 is an active ingredient found mainly in ginseng that has a variety of pharmacological effects, such as hypoglycemic, antioxidant, and anti-inflammatory effects, and it inhibits vascular formation. In this study, we explored the effect of ginsenoside Rg1 on angiogenesis in diabetic retinopathy (DR) on the basis of its ability to inhibit angiogenesis and the specific molecular mechanism involved.

Materials And Methods: We induced an in vivo model of diabetes by injection of 55 mg/kg streptozotocin (STZ) into the abdominal cavity of SD rats daily for 3 days.

Peripheral Inflammation Profile of Cerebellar Ataxia.

Objectives: The objective of this study is to determine the characteristics of peripheral inflammatory profiles and their correlations with the clinical features in patients with cerebellar ataxia.

Methods: We conducted a cross-sectional study on a cohort of 140 cerebellar ataxia patients, including 74 patients with spinocerebellar ataxia (SCA), 66 patients with multiple system atrophy with predominant cerebellar ataxia (MSA-C), and 145 healthy controls (HCs). Inflammatory profiles (PLT, MPV, NLR, PLR, MLR, SII, AISI and ESR) were measured in peripheral blood, and were compared by ANOVA and Kruskal-Wallis test.