A Novel Approach for Suprachoroidal Space Injection: An Experimental Evaluation.

Purpose: This study aims to describe an innovative suprachoroidal space injection technique using a combination of 30 G and 22 G needles attached to a 1 ml injector. The efficacy and applicability of this technique in suprachoroidal injections are evaluated.

Methods: In this study, we conducted both and injection experiments using isolated porcine eyes and live SD rats, respectively.

The chitosan confined pyrolysis strategy enhances the catalytic performance of a carbon material based on a novel carboxyl functionalized MOF.

A carboxyl functionalized metal-organic framework [Co(TPT)(bptc)]·3HO (Co-MOF (-COOH)) was designed with the aim of grafting protective CTS onto the surface as a precursor. Compared with direct carbonization and physical mixing carbonization, (Co-MOF--CTS)-900 prepared by confined pyrolysis shows excellent catalytic reduction performance.

Faecalibacterium prausnitzii Suppresses Mitophagy to Alleviate Muscle Atrophy in Chronic Renal Failure With Protein-Energy Wasting.

Protein-energy wasting (PEW) facilitates major adverse clinical outcomes in chronic renal failure (CRF), with current therapies not suitable for all patients. Faecalibacterium prausnitzii (F. prausnitzii) can alleviate chronic kidney disease, with unclear effects and mechanisms on CRF with PEW.

Weakly solvated perfluorinated electrolyte for high-temperature sodium-layered oxide cathodes.

The stability of the electrode-electrolyte interface in layered oxides is enhanced by electrolyte design criteria. A weakly-solvated electrolyte containing ethyl trifluoroacetate solvents with perfluorinated functional groups can restrain electrolyte decomposition and structural degradation when subjected to heat attack, exhibiting superior cycling durability at 60 °C compared to other fluorinated electrolytes.

Recent Advances in Polyvinylidene Fluoride with Multifunctional Properties in Nanogenerators.

Amid the global energy crisis and rising emphasis on sustainability, efficient energy harvesting has become a research priority. Nanogenerators excel in converting abundant mechanical and thermal energy into electricity, offering a promising path for sustainable solutions. Among various nanogenerator's materials, Polyvinylidene fluoride (PVDF), with its distinctive molecular structure, exhibits multifunctional electrical properties including dielectric, piezoelectric and pyroelectric characteristics.

Architecting of All-Cellulose-Based Wicking Fabric for a Large-Scale, Low-Cost, and Highly Efficient Solar Desalination Evaporator.

Interfacial solar vapor generation (ISVG) technology has been considered a promising and sustainable strategy for seawater desalination and wastewater treatment. However, its practical application is greatly limited due to severe salt accumulation and poor long-term evaporation stability. Herein, an all-cellulose-based wicking fabric (CB@CA/CF) is fabricated via a breath figure template (BFT) method for high-performance and stable desalination.

Exploring Carbon Dots for Biological Lasers.

Biological lasers, representing innovative miniaturized laser technology, hold immense potential in the fields of biological imaging, detection, sensing, and medical treatment. However, the reported gain media for biological lasers encounter several challenges complex preparation procedures, high cost, toxicity concerns, limited biocompatibility, and stability issues along with poor processability and tunability. These drawbacks have impeded the sustainable development of biological lasers.

Adherence to phase I cardiac rehabilitation in post-PCI patients: a latent class analysis.

Background: Coronary heart disease seriously jeopardizes human health and has become a principal public health problem of global concern. While percutaneous coronary intervention (PCI) repairs narrowed arteries and extends patients' lives, cardiac rehabilitation offers additional benefits post-PCI. Numerous previous studies have shown that cardiac rehabilitation can inhibit the progression of atherosclerotic plaques in patients after coronary intervention, effectively controlling patients' clinical symptoms and improving their quality of life.

Shuhe granule for insomnia: study protocol for a double-blind, randomized, placebo-controlled trial.

Introduction: Modern medical treatment of insomnia is often associated with issues like addiction, drug resistance, and a high risk of relapse post drug withdrawal. To tackle these challenges, the Chinese medicine formula Shuhe granule (SHG) has been employed in insomnia treatment at Guangdong Provincial Hospital of Chinese Medicine. Despite this, there is currently a lack of reliable evidence from evidence-based trials to support the widespread use of SHG in insomnia treatment.

Biomimetic Self-Oxygenated Immunoliposome for Cancer-Targeted Photodynamic Immunotherapy.

Objective: Photodynamic therapy (PDT) is a promising strategy with significant clinical application potential for tumor treatment. However, the tumor hypoxia and limited efficacy against tumor metastasis present significant limitations in the clinical application of PDT. To alleviate tumor hypoxia for PDT against tumor growth and metastasis, we developed a self-oxygenated immunoliposome by encapsulating the catalase (CAT) within the liposome cavity and loading the photosensitizer chlorin e6 (Ce6) and immunoadjuvant MPLA in the lipid bilayer of the immunoliposome (CAT@LP-Ce6-A).

Changes in Respiratory Sensitivity Status of Patients in a Hospital in Shanxi Province Before and After the COVID-19 Epidemic.

Background: The lifting of the regional blockade in early December 2022 in Shanxi Province, China, caused an epidemic of Coronavirus disease 2019 (COVID-19). And the high allergy season from July to September each year.

Purpose: To investigate the effect of the COVID-19 epidemic on the respiratory sensitivity status of the population, to provide a scientific and effective basis for the prevention, diagnosis, condition assessment, and treatment of allergic respiratory diseases.

Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies.

Pulmonary hypertension (PH) stands as a tumor paradigm cardiovascular disease marked by hyperproliferation of cells and vascular remodeling, culminating in heart failure. Complex genetic and epigenetic mechanisms collectively contribute to the disruption of pulmonary vascular homeostasis. In recent years, advancements in research technology have identified numerous gene deletions and mutations, in addition to , that are closely associated with the vascular remodeling process in PH.

Carabrone Attenuates Metabolic Dysfunction-Associated Steatohepatitis by Targeting STAT3 in Mice.

Metabolic dysfunction-associated steatohepatitis (MASH) has become one of the most common progressive liver diseases worldwide, but effective treatment options are severely unmet. Carabrone, a sesquiterpene lactone from the traditional Chinese herb L., shows various pharmacological properties, whereas its effect on the improvement of MASH and the underlying mechanisms have not yet been reported.

Reducing the impact of peer victimization on adolescent insomnia: Which is more important, peers or family support?

Background: Adolescent insomnia is a global public health issue, with peer victimization identified as one of the risk factors. However, some adolescents are able to resist the negative impact of peer victimization, and the protective mechanisms underlying this resilience require further clarification. This study aims to evaluate the moderating roles of friendship quality and family functioning on the effects of peer victimization on insomnia.

Vaccarin Ameliorates Renal Fibrosis by Inhibiting Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway.

Purpose: Vaccarin is a natural flavonoid glycoside with anti-inflammatory, antioxidant and nephroprotective effects. However, the effects of vaccarin on renal fibrosis (RF) and its molecular mechanisms remain unclear. This study aimed to investigate the effects of vaccarin on RF and its molecular mechanisms.

Dose-Response Study of Remimazolam Combined With Remifentanil for Attenuating Stress Response During Laryngeal Mask Airway Insertion in Elderly Female Patients: A Prospective Double-Blinded Study.

Background: Optimum dose of remimazolam for inducing loss of consciousness in elderly patients has been suggested by prior studies. Opioids can enhance their sedative effects, thereby permitting dose reduction. However, the dose-response of remimazolam when combined remifentanil for attenuating stress response during laryngeal mask airway (LMA) insertion in elderly female patients is still unknown.

3D bioprinted piezoelectric hydrogel synergized with LIPUS to promote bone regeneration.

Bone defects resulting from trauma, tumor resection, non-union of fractures, and infections present enormous challenges in treatment. Although three-dimensional (3D) bioprinting plays an important role in repairing bone tissues, the lack of mechanical properties and osteoinductive ability of the bioinks remains a barrier for the application of the technology. In this study, we used advanced 3D bioprinting technology to create a novel piezoelectric hydrogel scaffold (Gel/PBT@BMSCs) which consisted of bone marrow-derived mesenchymal stem cells (BMSCs), gelatin methacryloyl (GelMA), and polyethylene glycol (PEG)-modified barium titanate (BT) nanoparticles.

How positive emotions affect entrepreneurial intention of college students: A moderated mediation model.

Entrepreneurial intention (EI) is a crucial requirement for encouraging significant entrepreneurial activity, which is essential for economic growth and social stability. Cultivating college students' EI is a critical element of higher education. Based on the theory of planned behavior (TPB), this study constructs a moderated mediation model, aiming to explore the intricate processes and conditioning elements that influence the EI of college students and investigate the mediating role of future time perspective (FTP) between positive emotion (PE) and entrepreneurial intention (EI) among Chinese college students, as well as the moderating role of gender.

A novel single-domain antibody obtained from immune Bactrian camels against botulinum toxin type A using SPR-based screening method.

Botulinum neurotoxin (BoNT) is a highly lethal toxin produced by the anaerobic bacterium Clostridium botulinum, which leads to nerve paralysis following poisoning. At present, there is no specific drug officially approved. Antibodies, particularly single-domain antibodies, represent safe and effective candidates for specific drugs against BoNT.

The triglyceride-glucose index is associated with a higher risk of hypertension: evidence from a cross-sectional study of Chinese adults and meta-analysis of epidemiology studies.

Background: The results of population-based studies show a diverse association between the triglyceride-glucose (TyG) index and hypertension. The present study aimed to investigate this association based on a cross-sectional study on Chinese adults and meta-analysis of epidemiology studies.

Methods: The cross-sectional analysis used the baseline data from the on-going REACTION study in China.

Tough hydrogel-coated containment capsule of magnetic liquid metal for remote gastrointestinal operation.

Gallium-based liquid metals, when combined with magnetic agents, emerge as intelligent materials with potential applications in soft robotics within biomedical engineering. However, concerns have arisen from the residual presence of liquid metal, raising long-term biological risks. Herein, we propose a containment method that involves the rolling of magnetic liquid-metal droplets in lyophilized powders, resulting in the formation of intact hydrogel coatings upon hydration.

Multiple Myeloma Complicated With Bronchiolitis Obliterans Syndrome After Allogeneic Haematopoietic Stem Cell Transplantation and Subsequently Underwent Lung Transplantation Successfully: A Case Report.

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for multiple myeloma; however, the development of chronic graft-versus-host disease remains a significant challenge. Bronchiolitis obliterans syndrome (BOS) is one of the complications. Even with available medications for treatment, the prognosis of BOS remains poor.

Nanofibrous Chitin Clusters Constructed via Controllable Crystalline Structure Transition for 3D Functional Materials.

Intensively studied polymeric particle production technologies often rely on the combination of polymer self-assembly and particle processing techniques. Herein, an elegant crystallization transition-mediated strategy is proposed to confine molecular self-assembly within a limited range, avoiding the need for extra particle processing steps. This approach enables the production of the regenerated nanofibrous chitin clusters woven with the helical nanofibers.

LncRNA CASC2 mediates SOCS6 mRNA stabilization via U2AF2 recruitment to modulate macrophage polarisation in diabetic retinopathy.

Background: Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes and a leading cause of vision loss among diabetic individuals. Retinal pigment epithelium (RPE) cells play a crucial role in the pathophysiology of DR by releasing cytokines and exosomal cargo, such as long non-coding RNAs (lncRNAs), that modulate local immune responses, maintain retinal immune homeostasis and influence macrophage polarisation. Recent studies suggest that lncRNA cancer susceptibility candidate 2 (CASC2) may be involved in the regulation of DR progression.