Publications by authors named "Zhuye Qin"
Article Synopsis
- * A new monoclonal chimeric IgG1 antibody, called 4G6, has been developed from a murine-specific antibody for the inner lipoyl domain of PDC-E2 and can recognize all AMA epitopes used in current diagnostic tests.
- * The 4G6 antibody demonstrates strong binding affinity, making it a reliable quantitative reference for AMA testing and a promising standard for international use.
Objectives: Antibodies to gp210 and sp100 are specific and unique anti-nuclear autoantibodies (ANAs) associated with primary biliary cholangitis (PBC). Importantly the presence of anti-gp210 and anti-sp100 responses is indicative of poor clinical outcomes. However, the utility of measuring titers of these antibodies remains unclear.
View Article and Find Full Text PDFAssociation of CCR6 functional polymorphisms with Primary Biliary Cholangitis.
J Transl Autoimmun
June 2024
Article Synopsis
- Biliary epithelial cells in primary biliary cholangitis (PBC) patients release specific chemokines that attract CCR6 T cells, resulting in their infiltration into the biliary epithelium.
- A multi-national genome-wide meta-analysis, including a cohort from Han Chinese, found significant single nucleotide polymorphisms (SNPs) linked to PBC, categorized into "protective" and "risk" groups.
- Further analysis revealed that only the "risk" SNPs were consistently associated with PBC in a separate Han Chinese cohort, indicating a genetic vulnerability specific to this population.