Regulation of the HMGA2-SNAI2/CXCR4 axis in atherosclerosis and retinal neovascularization: new therapeutic insights.

Atherosclerosis (AS) is a vascular disease associated with endothelial damage, plaque formation, and retinal neovascularization (RNV), leading to visual impairment. Research indicates that vascular endothelial dysfunction, lipid deposition, and inflammatory responses contribute to the formation of plaques and atherosclerotic lesions. Among the common complications, studies have shown that RNV and the molecular mechanisms of AS hold significant clinical importance.

Effects of dietary polyphenols on maternal and fetal outcomes in maternal diabetes.

The incidences of short-term or long-term adverse maternal and fetal outcomes caused by maternal diabetes are increasing. Due to toxicity or side effects, economic pressures, and other problems associated with injections or oral hypoglycemic drugs, many researchers have investigated natural treatment methods. Polyphenols can protect against chronic pathologies by regulating numerous physiological processes and provide many health benefits.

Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice.

Sirtuin 1 (SIRT1), is a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase and a candidate gene for depression. Nicotinamide (NAM), a form of vitamin B3, is reported as a potential inhibitor of SIRT1. Our previous study found that the 24-h-restraint stress could induce long-term depressive-like phenotypes in mice.

Dysregulation of neuron differentiation in an autistic savant with exceptional memory.

Autism spectrum disorder (ASD) is a heterogeneous group of complex neurodevelopmental disorders without a unique or definite underlying pathogenesis. Although savant syndrome is common in ASD, few models are available for studying the molecular and cellular mechanisms of this syndrome. In this study, we generated urinary induced pluripotent stem cells (UiPSCs) from a 13-year-old male autistic savant with exceptional memory.

Topological crystalline superconductors in two dimensions.

We propose a general framework to classify the topological edge modes in two dimensional topological crystalline superconductors with time-reversal symmetry, which are protected by different crystalline symmetries. The realization of topological crystalline phases is investigated in the superconductors and a criterion for distinguishing topological phases in crystalline superconductor both with mirror and mirror-inversion symmetry is founded. In these topological phases, Majorana edge modes can be identified along the mirror invariant line, while topological edge modes in the AIII class exist along the mirror-inversion invariant line.

Fractional charged edge states in ladder topological insulators.

We propose a model of two-leg ladder topological insulator in which the spin-orbit couplings are presented in both intra-chain and inter-chain interactions. The topological phase supports four fractional charged edge states localized at opposite ends of the ladder, which belongs to the chiral symplectic (CII) class protected by time-reversal symmetry and chiral symmetry. In our model, the presence of time-reversal and chiral symmetry generates fourfold degeneracy for the edge states, and the two edge states with same chirality at one end of the ladder each carries half charge.

MiR-134 modulates chronic stress-induced structural plasticity and depression-like behaviors via downregulation of Limk1/cofilin signaling in rats.

Increasing evidence has suggested that depression is a neuropsychiatric condition associated with neuroplasticity within specific brain regions. However, the mechanisms by which neuroplasticity exerts its effects in depression remain largely uncharacterized. In the present study we show that chronic stress effectively induces depression-like behaviors in rats, an effect which was associated with structural changes in dendritic spines and synapse abnormalities within neurons of the ventromedial prefrontal cortex (vmPFC).

Ginsenoside Rg1 reverses stress-induced depression-like behaviours and brain-derived neurotrophic factor expression within the prefrontal cortex.

Depression is a major neuropsychiatric disorder that exerts deleterious effects upon public health. However, the neuronal mechanisms of depression remain largely uncharacterized, which has retarded the identification and development of effective therapeutic tools for the treatment of this disorder. The aim of this study was to explore the neuronal mechanisms underlying the protective effects of ginsenoside Rg1, a natural steroidal saponin found in ginseng, against chronic stress-induced depression.

L-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2 S pathway in rodent jejunum.

Hydrogen sulphide (H2 S) is generated endogenously from L-cysteine (L-Cys) by the enzymes cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE). In addition, L-Cys is commonly used as a precursor in the food and pharmaceutical industries. The aim of the present study is to determine whether L-Cys regulates intestinal nutrient transport.